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Chlorzoxazone + Diclofenac + Paracetamol


Uses of Chlorzoxazone + Diclofenac + Paracetamol

  • Chlorzoxazone + Diclofenac + Paracetamol combination is a pain reliever used to treat acute pain associated with musculoskeletal disorders with associated skeletal muscle spasms

Side effects of Chlorzoxazone + Diclofenac + Paracetamol

  • Abdominal pain
  • Constipation
  • Diarrhea
  • Indigestion
  • Flatulence 
  • Gross bleeding/perforation
  • Heartburn 
  • Nausea
  • GI ulcers (gastric/duodenal)
  • Vomiting

How Chlorzoxazone + Diclofenac + Paracetamol works

  • Chlorzoxazone is a muscle relaxant that acts on the spinal cord and certain brain areas to stop reflexes that cause muscle spasms. This helps reduce muscle spasms, relieve pain, and improve movement.
  • Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID) that inhibits the production of certain chemicals in the body called prostaglandins. These are responsible for inflammation, pain, and fever. Diclofenac helps reduce pain, inflammation, and swelling by blocking their production.
  • Paracetamol is an analgesic and antipyretic agent. It inhibits prostaglandin synthesis in the brain to lower fever and reduce pain.

Certified content

Written By

Amit SharmaClinical Health & Medical Writer| 3 Years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 12 Years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • This combination can be taken orally (tablet).

Age and Dose Restrictions

  • This combination is intended to be used by adults only. It is not recommended for children.


  • This combination is contraindicated in patients with a history of hypersensitivity to chlorzoxazone, diclofenac and paracetamol. It is also contraindicated in patients with active or a history of recurrent peptic ulcer/haemorrhage.

Medications to Avoid with This Drug

  • Avoid taking antiarrhythmics (digoxin), diuretics, antihypertensives, anticoagulants, other NSAIDs, immunosuppressive medications (methotrexate, cyclosporine, and tacrolimus), quinolone antimicrobials, antidiabetics, anticonvulsants (phenytoin), prokinetic agents (metoclopramide and domperidone), opioid medications (codeine, dihydrocodeine, and hydrocodone), antipsychotics, antianxiety medications, pemetrexed and cholesterol-lowering medications (colestipol and cholestyramine). These medications may alter the safety and effectiveness of Chlorzoxazone + Diclofenac + Paracetamol.

Overdose and Missed Dose

  • Overdose can cause lethargy, drowsiness, nausea, vomiting, and abdominal pain. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
  • If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management of Side Effects

  • Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • This combination can make you feel dizzy, drowsy, and lightheaded. Do not drive, operate machinery, or do other activities that require mental alertness or coordination if you experience these side effects. 

Use in Pregnancy and Lactation

  • This combination is not recommended during pregnancy, specifically during the third trimester. Caution is advised in breastfeeding women.

Caution in Other Conditions

  • Caution is advised in older adults and patients with heart conditions, asthma, hypertension, acute porphyria, pre-existing asthma and kidney and liver impairment.

Special Dietary & Lifestyle Recommendation

  • Avoid alcohol consumption, as it may increase the risk of adverse side effects.
  • Excess weight can put a strain on joints and exacerbate pain. Aim to maintain a healthy weight through a balanced diet and regular exercise.
  • Perform gentle stretches to improve flexibility and prevent muscle stiffness. Avoid overstretching, especially if you have an injury.
  • You may apply a warm compress or ice pack to affected areas for relief from muscle spasms.
  • Choose comfortable, supportive shoes to minimise the impact on joints and muscles.

Frequently asked questions

Yes, this combination is a painkiller. This combination helps alleviate pain associated with musculoskeletal disorders and muscle spasms.

This combination typically show their effects within 30 minutes to an hour after ingestion. However, individual responses may vary. 

This combination is not habit-forming and is generally safe when used as directed.

The use of this combination is not known to impair female fertility. However, it's best to consult your doctor if you have any concerns. 

This combination usually requires a prescription and is not available over the counter.

This combination may relieve pain for up to a few hours. However, the duration of effect of this medication can vary with the individual and the severity of the condition being treated.

Terms & Conditions

Sorry we currently were not able to find medicines related to CHLORZOXAZONE + DICLOFENAC + PARACETAMOL.


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