Chlorzoxazone + Diclofenac + Paracetamol

Dosage Forms Available

• This combination can be taken orally (tablet).

Age and Dose Restrictions

• This combination is intended to be used by adults only. It is not recommended for children.

Contraindications

• This combination is contraindicated in patients with a history of hypersensitivity to chlorzoxazone, diclofenac and paracetamol. It is also contraindicated in patients with active or a history of recurrent peptic ulcer/haemorrhage.

Medications to Avoid with This Drug

• Avoid taking antiarrhythmics (digoxin), diuretics, antihypertensives, anticoagulants, other NSAIDs, immunosuppressive medications (methotrexate, cyclosporine, and tacrolimus), quinolone antimicrobials, antidiabetics, anticonvulsants (phenytoin), prokinetic agents (metoclopramide and domperidone), opioid medications (codeine, dihydrocodeine, and hydrocodone), antipsychotics, antianxiety medications, pemetrexed and cholesterol-lowering medications (colestipol and cholestyramine). These medications may alter the safety and effectiveness of Chlorzoxazone + Diclofenac + Paracetamol.

Overdose and Missed Dose

• Overdose can cause lethargy, drowsiness, nausea, vomiting, and abdominal pain. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
• If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management of Side Effects

• Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

• This combination can make you feel dizzy, drowsy, and lightheaded. Do not drive, operate machinery, or do other activities that require mental alertness or coordination if you experience these side effects. 

Use in Pregnancy and Lactation

• This combination is not recommended during pregnancy, specifically during the third trimester. Caution is advised in breastfeeding women.

Caution in Other Conditions

• Caution is advised in older adults and patients with heart conditions, asthma, hypertension, acute porphyria, pre-existing asthma and kidney and liver impairment.

Special Dietary & Lifestyle Recommendation

• Avoid alcohol consumption, as it may increase the risk of adverse side effects.
• Excess weight can put a strain on joints and exacerbate pain. Aim to maintain a healthy weight through a balanced diet and regular exercise.
• Perform gentle stretches to improve flexibility and prevent muscle stiffness. Avoid overstretching, especially if you have an injury.
• You may apply a warm compress or ice pack to affected areas for relief from muscle spasms.
• Choose comfortable, supportive shoes to minimise the impact on joints and muscles.