Drotaverine + Paracetamol/Acetaminophen is primarily used for the symptomatic relief of abdominal pain and cramps associated with conditions like irritable bowel syndrome, menstrual cramps, renal colic, and intestinal spasms. It belongs to the group of antispasmodic and analgesic medicines.
In addition, it can also be indicated for post-operative abdominal cramps and smooth muscle spasms in the gastrointestinal, biliary, and urinary tracts.
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Drotaverine + Paracetamol/Acetaminophen is a combination with antispasmodic and analgesic properties.
Drotaverine is an antispasmodic. It works by relaxing the smooth muscles in the stomach and intestines. It does this by blocking certain enzymes inside cells, which increases certain substances (cyclic AMP and cyclic GMP). These substances reduce the availability of another substance (calcium), which helps to relax muscles and relieve spasms and cramps.
Paracetamol/Acetaminophen is an analgesic and antipyretic. Its exact mechanism is not fully understood, but it is thought to work mainly in the brain. It blocks certain enzymes and reduces the production of specific substances (prostaglandins), which helps to reduce pain signals and fever.
Together, these components work in harmony to manage pain and muscle spasms associated with conditions like menstrual cramps, intestinal spasms, and other related conditions.
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Drotaverine + Paracetamol/Acetaminophen is available as oral tablets.
This combination is meant for use by adults. It is suitable for children only under specific guidance from a doctor regarding appropriate dosages based on body weight.
Drotaverine + Paracetamol/Acetaminophen is contraindicated in patients with severe hepatic impairment.
This medicine is also contraindicated in individuals with acute liver disease and severe renal insufficiency (CrCl < 10 mL/min).
This combination may interact with CYP3A4 and CYP2D6 inhibitors (such as ketoconazole and quinidine), CYP3A4 inducers (like rifampicin and phenytoin), antihypertensives (including amlodipine, lisinopril), nitrates (such as nitroglycerin, isosorbide), warfarin, and lamotrigine.
It is crucial to consult a doctor before starting any new medications while taking this combination.
An overdose of Drotaverine + Paracetamol/Acetaminophen can lead to severe hepatotoxicity and symptoms such as nausea, vomiting, abdominal pain, hypotension, and CNS depression. If suspected, seek immediate medical attention.
If you miss a dose of this medicine, take it as soon as you remember unless it is close to the time for your next dose. In that case, skip the missed dose and proceed with your regular dosing schedule. Do not take a double dose to make up for the missed one.
Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
If experiencing dizziness or headaches, consider resting in a quiet, dark room and drinking plenty of water.
For dry mouth or thirst, sipping water regularly or chewing sugar-free gum may help.
Drotaverine + Paracetamol/Acetaminophen may cause side effects like dizziness or drowsiness which could affect your ability to drive or operate machinery safely. Avoid engaging in these activities if you do not feel alert.
The safety of using Drotaverine + Paracetamol/Acetaminophen during pregnancy or lactation has not been conclusively established. It should only be used when clearly necessary and under the advice of a doctor.
Individuals with mild to moderate hepatic or renal impairment should use Drotaverine + Paracetamol/Acetaminophen with caution. Regular monitoring by a doctor may be necessary.
Patients with G6PD deficiency should be cautious due to the risk of hemolytic anaemia from paracetamol.
Ensure adequate hydration by drinking plenty of fluids; this can help manage abdominal conditions treated by Drotaverine + Paracetamol/Acetaminophen.
Consuming a balanced diet rich in fibre can help alleviate symptoms of conditions like irritable bowel syndrome.
Regular gentle exercise such as walking can improve digestion and reduce stress levels which might exacerbate abdominal pain.
Avoiding caffeine and spicy foods can help reduce gastrointestinal irritation and minimise abdominal discomfort.
Frequently asked questions
Yes, Drotaverine, one of the components of this combination, acts as an antispasmodic, which means it helps to relax the smooth muscles in the gastrointestinal tract and other organs to relieve spasms and cramps.
Yes, this combination is often indicated for the symptomatic relief of menstrual cramps, also known as dysmenorrhea.
It typically starts to work within 30 minutes to 1 hour after ingestion, providing relief from pain and cramps.
No, this combination is not a steroid. Drotaverine is an antispasmodic agent and Paracetamol, also known as Acetaminophen, is an analgesic and antipyretic.
Drotaverine + Paracetamol/Acetaminophen has to be taken with food. It is usually recommended to take medicine after meals to avoid any potential gastric discomfort.
There is no evidence suggesting dependency or addiction associated with the use of this combination. It is a non-narcotic medication used for symptomatic relief of pain and cramps.
It is generally advised to avoid alcohol consumption during the treatment period with Drotaverine + Paracetamol/Acetaminophen, as alcohol may increase the risk of liver damage, especially with Paracetamol use.
Drotaverine + Paracetamol/acetaminophen in other salts
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