Dexketoprofen + Paracetamol/Acetaminophen is primarily used for the short-term symptomatic treatment of moderate to severe pain such as post-operative pain, menstrual pain, musculoskeletal pain, and dental pain in adult patients. It belongs to the group of analgesic and antipyretic medicines.
Additionally, it can also be used to reduce fever.
Nausea
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Indigestion
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Dexketoprofen + Paracetamol/Acetaminophen is a combination analgesic.
Dexketoprofen is a nonsteroidal anti-inflammatory medicine. It works by inhibiting enzymes called cyclooxygenase (COX-1 and COX-2) that lead to the reduction of prostaglandin synthesis. Prostaglandins are substances in the body that cause pain and inflammation. By limiting their production, dexketoprofen eases pain and decreases inflammation.
Paracetamol/Acetaminophen is a centrally acting pain reliever and fever reducer. It is thought to work by preventing the production of prostaglandins in the brain and peripheral tissues, which helps to reduce pain signals. It also acts on the heat-regulating centre in the brain to lower body temperature when you have a fever.
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BMS, FMC, MD Resident
Dexketoprofen + Paracetamol/Acetaminophen is available as oral tablets and powders.
In addition, this combination also available in effervescent tablets or suspension forms for ease of administration, particularly for patients who have difficulty swallowing tablets.
This medicine is meant for use in adult patients only.
This combination is contraindicated in patients with hypersensitivity to any of its components.
It is also contraindicated in people with active peptic ulcer, gastrointestinal bleeding, inflammatory bowel disease, severe heart failure, and severe renal or hepatic insufficiency.
Patients who have experienced asthma or bronchospasm related to NSAIDs usage should not use this combination.
This combination may interact with other NSAIDs (such as ibuprofen and aspirin), diuretics (like furosemide), antihypertensives (such as lisinopril), anticoagulants (like warfarin), SSRIs (such as fluoxetine), cardiac glycosides (including digoxin), cyclosporine, and medications that affect liver enzymes such as CYP2E1 inducers (like rifampicin).
An overdose of this combination may result in gastrointestinal symptoms, drowsiness, dizziness, hypotension, renal failure, and respiratory depression. In case of suspected overdose, seek immediate medical attention.
If you miss a dose of this combination, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular dosing schedule. Do not take a double dose to make up for the forgotten one.
Most side effects are temporary and generally harmless and resolve when discontinuing this combination. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
To manage mild gastrointestinal upset, consider taking the medication with food or a glass of milk.
Ensure adequate hydration by drinking plenty of water throughout the day which may help alleviate some side effects like dizziness or headache.
Dexketoprofen + Paracetamol/Acetaminophen may cause dizziness or drowsiness. Therefore, avoid driving or operating heavy machinery until you know how this medication affects you.
Dexketoprofen + Paracetamol/Acetaminophen is contraindicated in the third trimester of pregnancy and is not recommended during the first and second trimesters unless clearly necessary. The combination should be avoided during breastfeeding.
Consult your doctor before using this medicine during pregnancy and lactation.
Caution is advised when using this medication in the elderly or those with renal or hepatic impairment.
Individuals with hypertension or cardiac conditions should also use this medication cautiously.
Stay hydrated by drinking plenty of water which can aid in maintaining good kidney function while on this medication.
Avoid excessive intake of salt to manage blood pressure levels if you are prone to hypertension.
Frequently asked questions
No, it is not a steroid. Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID), and paracetamol, also known as acetaminophen, is an analgesic and antipyretic.
There is no conclusive evidence to suggest this combination interferes with sleep. However, if you experience sleep disturbances after taking this medicine, you should consult your doctor.
It should only be used for the duration prescribed by your doctor. Long-term use can increase the risk of side effects.
There is no evidence to suggest that this combination affects fertility. However, if you are trying to conceive and are concerned about fertility, it is always best to consult your doctor.
It provides fast pain relief, with the onset of analgesia within 30 minutes of oral administration.
Yes, it is not available over the counter and requires a prescription from your doctor.
There is no evidence to suggest that it affects mood or hormonal balance. But if you notice any changes in mood or hormones after taking this medication, please consult your doctor.
Dexketoprofen + Paracetamol/acetaminophen in other salts
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