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Ondansetron + Paracetamol/acetaminophen

Uses of Ondansetron + Paracetamol/acetaminophen

  • The primary use of Ondansetron + Paracetamol/Acetaminophen is to prevent and manage nausea and vomiting caused by surgery, cancer chemotherapy, and radiation therapy. This medicine falls into the categories of serotonin 5-HT3 receptor antagonists and non-opioid analgesics and antipyretics.

  • Additionally, it is used to provide relief from mild to moderate pain including headaches, muscle aches, menstrual cramps, toothaches, and backaches. It is also effective in reducing fever.

Side effects of Ondansetron + Paracetamol/acetaminophen

  • Headache

  • Fatigue or weakness

  • Drowsiness

  • Dizziness

  • Dry mouth

How Ondansetron + Paracetamol/acetaminophen works

  • Ondansetron + Paracetamol/Acetaminophen is a combination medicine that combines an antiemetic with an analgesic and antipyretic.

  • Ondansetron falls under the category of serotonin 5-HT3 receptor antagonists. It works by blocking serotonin, a natural substance produced in the body that can induce nausea and vomiting.

  • Paracetamol/Acetaminophen is a non-opioid analgesic and antipyretic. It functions by reducing the production of prostaglandins, substances in the body that cause pain and fever.

Certified content

Written By

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Dr. Michelle FrankMedical Content Writer| 8 years

Doctor of Medicine

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Ondansetron + Paracetamol/Acetaminophen is available in various oral formulations. These include regular tablets, orally disintegrating tablets (ODT), oral solution, and oral suspension to be taken by mouth.

  • The orally disintegrating tablets should be placed on the tongue and allowed to dissolve completely before swallowing. For the oral solution and oral suspension, it is recommended to shake well before each use, ensuring proper dosage consistency.

Age and Dose Restrictions

  • Ondansetron + Paracetamol/Acetaminophen is intended for use in both adults and children. The minimum age for children’s use depends on specific product formulations and dosages.

Contraindications

  • This medicine is contraindicated in patients with known hypersensitivity or allergy to either ondansetron or paracetamol/acetaminophen.

  • It is also contraindicated in patients suffering from severe liver disease or certain types of heart conduction disorders.

Other Medications to Avoid

  • This combination may interact with certain medications, including antidepressants (such as fluoxetine), anticonvulsants (like phenytoin or carbamazepine), and opioid analgesics (such as tramadol).

  • Consulting a doctor before starting any new medications while taking Ondansetron + Paracetamol/Acetaminophen is crucial to prevent adverse interactions.

Overdose and Missed Dose

  • An overdose of Ondansetron + Paracetamol/Acetaminophen can lead to severe liver damage or serotonin syndrome, characterised by confusion, rapid heart rate, and high blood pressure. Immediate medical help is essential in case of an overdose.

  • If you miss a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not take a double dose to make up for the forgotten one.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • For mild headaches or dizziness, resting in a quiet, dark room may help.

  • In case of constipation, increasing intake of fibre-rich foods and water can be beneficial.

  • If experiencing dry mouth, sipping water regularly or using sugar-free candies can offer relief.

Use in Driving and Operating Machinery

  • Ondansetron + Paracetamol/Acetaminophen may cause dizziness or drowsiness. It is advisable to avoid driving or operating heavy machinery until you know how this medicine affects you.

Use in Pregnancy and Lactation

  • The safety of using Ondansetron + Paracetamol/Acetaminophen during pregnancy or while breastfeeding has not been fully established. It is recommended to consult a doctor before using this medicine if you are pregnant or nursing.

Caution in Other Conditions

  • Caution is advised when using Ondansetron + Paracetamol/Acetaminophen in patients with liver disease due to the risk of increased liver damage.

  • Patients with a history of heart rhythm abnormalities should use this medication cautiously due to potential effects on heart rhythm associated with ondansetron.

Special Dietary and Lifestyle Recommendations

  • Stay hydrated by drinking plenty of fluids. This helps manage any potential side effects such as dry mouth or constipation.

  • Maintain a balanced diet rich in fibre which can help alleviate constipation associated with the use of this medication.

  • Regular moderate exercise can help maintain overall health and assist in managing symptoms like muscle aches that sometimes necessitate the use of pain relievers.

  • Avoid consuming alcohol as it can increase the risk of liver damage when taking paracetamol/acetaminophen-containing products.

Frequently asked questions

No, Ondansetron + Paracetamol/Acetaminophen is not a steroid. Ondansetron falls under the category of anti-nausea medicines known as serotonin 5-HT3 receptor antagonists, while Paracetamol/Acetaminophen is a pain reliever and fever reducer.

The combination of Ondansetron and Paracetamol/Acetaminophen can potentially cause drowsiness in some patients. If you notice this side effect, it is advised to consult your doctor for further advice.

There is no established evidence to suggest that Ondansetron + Paracetamol/Acetaminophen directly impacts fertility. However, if you are trying to conceive and have concerns, it is best to raise these with your doctor.

There are no specific dietary restrictions linked with taking Ondansetron + Paracetamol/Acetaminophen. However, it is generally advised to maintain a balanced diet while under any medication.

Ondansetron + Paracetamol/Acetaminophen should be taken according to the duration and frequency recommended by your doctor. It is not typically meant for long-term daily use.

The onset of action for both Ondansetron and Paracetamol/Acetaminophen can vary, but generally, relief from symptoms can be expected within 30 minutes to an hour after administration.

The best time to take Ondansetron + Paracetamol/Acetaminophen would depend on the specific advice of your doctor. However, for preventing chemotherapy-induced nausea and vomiting, Ondansetron is typically taken 30 minutes before treatment begins.

Terms & Conditions


Ondansetron + Paracetamol/acetaminophen in other salts

ACECLOFENAC + PARACETAMOL/ACETAMINOPHENACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHENONDANSETRONACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + RABEPRAZOLEDEXTROPROPOXYPHENE + PARACETAMOL/ACETAMINOPHENLORNOXICAM + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDEXTROPROPOXYPHENE + DICYCLOMINE + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TRAMADOLDEXIBUPROFEN + PARACETAMOL/ACETAMINOPHENDICYCLOMINE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINCAFFEINE + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDEPARACETAMOL/ACETAMINOPHEN + RACEMETHIONINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECPM + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEONDANSETRON + RANITIDINECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATECAMYLOFIN + PARACETAMOL/ACETAMINOPHENCHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATEPARACETAMOL/ACETAMINOPHEN + PROMETHAZINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDOMPERIDONE + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHENMETOCLOPRAMIDE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + FLUNARIZINE + PARACETAMOL/ACETAMINOPHENLEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEBROMHEXINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEIBUPROFEN + MAGNESIUM TRISILICATE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TIZANIDINEPARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRAMADOLCHLORZOXAZONE + PARACETAMOL/ACETAMINOPHENCAFFEINE + IBUPROFEN + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLPARACETAMOL/ACETAMINOPHEN + TAPENTADOLDICYCLOMINE + PAMABROM + PARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASECAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + DIPHENHYDRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDICLOFENAC + METHOCARBAMOL + PARACETAMOL/ACETAMINOPHENHYOSCINE + PARACETAMOL/ACETAMINOPHENETORICOXIB + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINFEXOFENADINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECODEINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHENDICLOFENAC + DICYCLOMINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENAZONEBROMHEXINE + CPM + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDEXTROPROPOXYPHENE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENONDANSETRON + RABEPRAZOLEDROTAVERINE + PARACETAMOL/ACETAMINOPHENDICYCLOMINE + MEFENAMIC ACID + PARACETAMOL/ACETAMINOPHENETODOLAC + PARACETAMOL/ACETAMINOPHENLORNOXICAM + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TIZANIDINEDEXKETOPROFEN + PARACETAMOL/ACETAMINOPHENBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENCHLORZOXAZONE + DICLOFENAC SODIUM + PARACETAMOL/ACETAMINOPHENCAFFEINE + CETIRIZINE + NIMESULIDE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + IBUPROFEN + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TOLPERISONECAFFEINE + CETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEONDANSETRON + PANTOPRAZOLEDEXTROPROPOXYPHENE + DICLOFENAC + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + PROCHLORPERAZINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + ERGOTAMINE + PARACETAMOL/ACETAMINOPHEN + PROCHLORPERAZINEPARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEAMBROXOL + CETIRIZINE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN
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