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Ibuprofen + Paracetamol/acetaminophen


Uses of Ibuprofen + Paracetamol/acetaminophen

  • This combination is used to treat mild to moderate pain associated with various conditions like headache, body aches, musculoskeletal pain and dysmenorrhoea and also due to inflammatory conditions.

Side effects of Ibuprofen + Paracetamol/acetaminophen

  • Nausea
  • Vomiting
  • Abdominal pain 
  • Flatulence
  • Constipation
  • Diarrhoea

How Ibuprofen + Paracetamol/acetaminophen works

  • Ibuprofen works as analgesic and antiinflammatory 
  • It works by inhibiting the Cyclooxygenase (COX 1 & COX 2) enzyme. This results in the prevention of prostaglandin synthesis which reduces the symptoms like pain, inflammation and swelling. 
  • Paracetamol is an Antipyretic and an Analgesic
  • It acts by inhibiting an enzyme called Cyclooxygenase, which reduces the prostaglandin chemicals responsible for causing pain and fever. 

Certified content

Written By

Amit SharmaClinical Health & Medical Writer| 3 Years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 12 Years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • This combination is available for use via the oral (tablet) route.

Age And Dose Restrictions

  • It is available for adults and children above six with appropriate dose calculation.


  • Ibuprofen and Paracetamol/Acetaminophen are CONTRAINDICATED in cases of hypersensitivity, history of gastrointestinal bleeding.

Medications To Avoid With This Drug

  • Avoid taking diuretics, anticoagulants (warfarin), immunosuppressive medications (methotrexate), antihypertensives, and other NSAIDs (aspirin). These medications may alter the safety and effectiveness of this combination.

Overdose And Missed Dose

  • Overdose of Ibuprofen and Paracetamol/Acetaminophen can cause nausea, vomiting, and abdominal pain. Serious effects like gastrointestinal bleeding and liver damage can also occur which require prompt management in a hospital setting.
  • If a dose is missed for paracetamol+ibuprofen, then it should be taken if there is a time gap from the subsequent dose.

Management Of Side Effects

  • Taking this medication in combination with food can relieve some associated gastrointestinal side effects like nausea, vomiting and abdominal pain.

Use In Driving And Operating Machinery

  • This medicine can make you feel dizzy. Do not drive, operate machinery, or do other activities that require mental alertness or coordination if you experience these side effects.

Use In Pregnancy And Lactation

  • It is not safe to use Paracetamol+ibuprofen in pregnant women, especially in the last trimester of pregnancy. Caution is advised for the use of this combination in breastfeeding mothers.

Caution In Other Conditions

  • Caution is required in case of severe kidney or liver failure and heart failure.

Special Dietary And Lifestyle Recommendation

  • Alcohol consumption should be avoided when using paracetamol+ibuprofen.
  • Adequate Hydration is an essential component in the management of fever, which should be ensured as a priority. 
  • high grade fever (>104 degrees fahrenheit) requires cold water sponging in addition to paracetamol and immediate admission to a hospital. 

Frequently asked questions

There are no interactions between Paracetamol+ibuprofen with Vitamin -B Complex supplements. So, this combination can be taken.

No, Paracetamol+ibuprofen is not a usual combination medicine for stomach pain.

No, Paracetamol + ibuprofen are not addictive.

No. It is not a usual effect of this combination.

Yes, nausea and vomiting are common side effects of Paracetamol+ibuprofen combination medicine.

No, Paracetamol+ibuprofen does not affect fertility.

No. It should be taken for the prescribed duration.

It may take up to 30-60 minutes for Ibuprofen +Paracetamol/Acetaminophen to show its effect.

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