Mefenamic Acid + Paracetamol
Analgesic/AntipyreticUses of Mefenamic Acid + Paracetamol
Mefenamic Acid + Paracetamol is a combination pain reliever used to manage moderate pain, fever, and inflammation.
This combination is commonly used for:
- Menstrual pain (dysmenorrhoea): Provides effective relief from cramping and lower abdominal pain associated with menstruation by reducing the production of prostaglandins involved in pain and uterine contractions.
- Headache and migraine: Relieves mild-to-moderate headache pain, including tension headaches and menstrual migraines.
- Fever: Reduces elevated body temperature associated with infections, inflammatory conditions, or post-vaccination reactions.
- Muscle and joint pain: Eases pain and stiffness caused by musculoskeletal conditions, sports injuries, or inflammatory joint disorders.
- Post-operative and dental pain: Provides short-term relief from mild-to-moderate pain following surgical or dental procedures.
- Toothache: Reduces localised pain and inflammation associated with dental conditions.
Side effects of Mefenamic Acid + Paracetamol
The side effects of Mefenamic Acid + Paracetamol are:
- Diarrhoea
- Nausea
- Vomiting
- Abdominal pain
- Constipation
- Indigestion
How Mefenamic Acid + Paracetamol works
- Mefenamic Acid + Paracetamol works through two complementary pain-relieving mechanisms that together provide more comprehensive relief than either medicine alone.
- Mefenamic Acid is a non-steroidal anti-inflammatory drug (NSAID). It works by blocking the enzyme cyclooxygenase (COX), which the body uses to produce prostaglandins chemicals responsible for causing pain, inflammation, and fever at the site of injury or illness. By reducing prostaglandin production, Mefenamic Acid lowers inflammation, eases pain, and helps reduce fever. It is particularly effective for pain associated with prostaglandin-driven processes, such as menstrual pain.
- Paracetamol works primarily in the central nervous system (brain and spinal cord). It reduces pain perception by inhibiting prostaglandin synthesis in the brain . It also lowers body temperature by acting on the hypothalamus, the brain's temperature-regulating centre, helping to reduce fever.
- Together, the peripheral anti-inflammatory action of Mefenamic Acid and the central pain-modulating effect of Paracetamol provide enhanced relief for a wider range of pain and fever conditions.
Certified content
Written By
MBBS
Reviewed By
MBBS, DNB (OBGY)
Expert Advice
Dosage Forms Available
- Mefenamic Acid + Paracetamol can be taken orally (tablet and suspension).
Age And Dose Restrictions
- This combination is intended for adults and children over six months of age.
Contraindications
- This combination is contraindicated in patients with a history of hypersensitivity to mefenamic acid or paracetamol, patients with pre-existing asthma, aspirin-sensitive asthma, and during coronary artery bypass graft (CABG) surgery.
Other Medications To Avoid With This Medicine
- Avoid taking antacids (aluminium hydroxide), antiarrhythmics (digoxin), diuretics (furosemide), anticoagulants (warfarin), immunosuppressive medications (methotrexate), cholesterol-lowering medications (cholestyramine), prokinetic agents (metoclopramide and domperidone), anticonvulsants (carbamazepine), antihypertensives (amlodipine), antibiotics (amikacin, tobramycin, gentamicin), and other NSAIDs (aspirin) with this combination. These medications may alter the safety and effectiveness of Mefenamic Acid + Paracetamol.
Overdose And Missed Dose
- An overdose of Mefenamic Acid + Paracetamol can be serious. Symptoms may include nausea, vomiting, abdominal pain, drowsiness, dizziness, and gastrointestinal bleeding. Paracetamol overdose in particular can cause delayed but severe liver damage, even when initial symptoms appear mild. If you suspect an overdose, seek emergency medical attention immediately and do not wait for symptoms to worsen. Strict adherence to the prescribed dose is essential.
- If you miss a dose of this combination, take it as soon as you remember. If it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take two doses at the same time to compensate for the missed one.
Management Of Side Effects
- Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.
Use In Driving And Operating Machinery
- This combination can cause dizziness and drowsiness. It is not recommended to drive, operate machinery, or do other activities requiring mental alertness or coordination after this combination.
Use In Pregnancy And Lactation
- This combination is not recommended during the third trimester of pregnancy. Caution is advised during 1st and 2nd trimester of pregnancy and breastfeeding.
Caution In Other Conditions
- Caution is advised in older adults and patients with heart conditions, active ulceration/bleeding, chronic inflammation of the gastrointestinal tract and kidney and liver impairment.
Special Dietary And Lifestyle Recommendation
- Avoid alcohol consumption, as it may increase the risk of liver toxicity and adverse side effects.
- Take this combination only for the prescribed duration.
- Maintain a healthy weight. Excess weight can contribute to joint pain and inflammation, so maintaining a healthy weight can reduce these issues.
- Engage in regular, low-impact exercises such as walking, swimming, or cycling to improve flexibility and strengthen muscles.
Frequently asked questions
1. Is Mefenamic Acid + Paracetamol a painkiller?
Yes, this combination is a painkiller that helps reduce mild to moderate pain associated with various conditions.
2. How much time does Mefenamic Acid + Paracetamol take to work?
This combination typically show their effects within 30 minutes to an hour after ingestion. However, individual responses may vary.
3. Is Mefenamic Acid + Paracetamol a habit-forming medicine?
No, this combination is not habit-forming and is generally safe when used as directed.
4. Does Mefenamic Acid + Paracetamol affect fertility?
This combination may impair female fertility and is not recommended in women attempting to conceive.
5. Is Mefenamic Acid + Paracetamol combination available over the counter, or do I need a prescription?
This combination usually requires a prescription and is not available over the counter.
6. How long does the effect of Mefenamic Acid + Paracetamol combination last?
This combination may relieve pain for up to a few hours. However, the duration of effect of this medication can vary with the individual and the severity of the condition being treated.
7. Can Mefenamic Acid + Paracetamol combination be taken for stomach pain?
This combination can be effective in relieving painful menstruation. However, its use for stomach pain should only be done when a doctor advises.
8. What is Mefenamic Acid + Paracetamol used for?
Mefenamic Acid + Paracetamol is a combination used to relieve mild to moderate pain, inflammation, and fever. It effectively manages common issues such as headaches, migraines, toothaches, ear pain, menstrual cramps, muscle and joint pain, and arthritis. This combination is also helpful in alleviating pain after surgery and reducing fever and body aches caused by the flu or infections. Additionally, it can be used to manage discomfort from conditions like osteoarthritis and to reduce pain associated with minor injuries.
Mefenamic Acid + Paracetamol in other salts
List of medicines for Mefenamic Acid + Paracetamol
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