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Nimesulide + Paracetamol/acetaminophen


Uses of Nimesulide + Paracetamol/acetaminophen

  • Nimesulide + Paracetamol/Acetaminophen is an anti-inflammatory, analgesic and antipyretic agent used to reduce pain and swelling in conditions such as sports injuries, toothaches, dysmenorrhoea, postoperative pain and fever.
  • This combination is also used to reduce pain and inflammation in osteoarthritis.

Side effects of Nimesulide + Paracetamol/acetaminophen

  • Diarrhoea
  • Nausea
  • Vomiting
  • Abdominal pain
  • Constipation 
  • Indigestion
  • Dizziness
  • Heartburn

How Nimesulide + Paracetamol/acetaminophen works

  • Nimesulide + Paracetamol/Acetaminophen is a pain reliever.
  • Nimesulide is a nonsteroidal anti-inflammatory drug (NSAID). It works by targeting and blocking specific enzymes in the body called COX-2 enzymes. It helps reduce pain and inflammation by blocking their production.
  • Paracetamol is an analgesic and antipyretic agent. It inhibits prostaglandin synthesis in the brain to lower fever and reduce pain.

Certified content

Written By

Amit SharmaClinical Health & Medical Writer| 3 Years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Clinical Health & Medical Writer| 12 Years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Nimesulide + Paracetamol/Acetaminophen can be taken orally (tablet and suspension).

Age And Dose Restrictions 

  • This combination is intended to be used by adults and children above 12 years. 


  • This combination is contraindicated in patients with a history of hypersensitivity to nimesulide or paracetamol/acetaminophen. It is also contraindicated in patients with active or a history of recurrent peptic ulcers, gastrointestinal bleeding or other bleeding disorders. 

Medications To Avoid With This Drug

  • Avoid taking gastric acid reducers (cimetidine), antacids (aluminium hydroxide), antiarrhythmics (digoxin), diuretics (furosemide), anticoagulants (warfarin), immunosuppressive medications (methotrexate), cholesterol-lowering medications (cholestyramine), prokinetic agents (metoclopramide and domperidone), and anticonvulsants (carbamazepine). These medications may alter the safety and effectiveness of Nimesulide + Paracetamol/Acetaminophen.

Overdose And Missed Dose

  • Overdose can cause lethargy, drowsiness, nausea, vomiting, and abdominal pain. These symptoms need to be managed as an emergency in a hospital setting. Therefore, strict adherence to the prescribed dose is essential.
  • If you miss a dose of this combination, take it as soon as you remember. But, if the next dose is near, skip the missed dose and resume the regular dosing regime.

Management Of Side Effects

  • Take this combination with food to reduce gastrointestinal side effects and continue taking it as prescribed. If side effects worsen or persist, consult your doctor for a possible treatment plan adjustment.

Use In Driving And Operating Machinery

  • This combination can make you feel dizzy. It is not recommended to drive, operate machinery, or do other activities that require mental alertness or coordination after taking this combination. 

Use In Pregnancy And Lactation

  • This combination is not recommended during pregnancy and breastfeeding.

Caution In Other Conditions

  • Caution is advised in older adults and patients with heart conditions, severe coagulation disorders and kidney and liver impairment.

Special Dietary And Lifestyle Recommendation

  • Avoid alcohol consumption, as it may increase the risk of adverse side effects.
  • Take this combination only for the prescribed duration.
  • Excess weight can put a strain on joints and exacerbate osteoarthritis pain. Aim to maintain a healthy weight through a balanced diet and regular exercise.
  • You may apply a warm compress or ice pack to affected areas to relieve muscle pains.
  • Choose comfortable, supportive shoes to minimise the impact on joints and muscles.

Frequently asked questions

Yes, this combination is a painkiller. It helps alleviate pain and inflammation associated with various conditions.

This combination typically shows its effects within 30 minutes to an hour after ingestion. However, individual responses may vary. 

This combination is not habit-forming and is generally safe when used as directed.

The use of this combination may impair female fertility and is not recommended in women attempting to conceive.

This combination usually requires a prescription and is not available over the counter.

This combination may relieve pain for up to a few hours. However, the duration of effect of this medication can vary with the individual and the severity of the condition being treated.

This combination can be effective in relieving painful menstruation. However, its use for stomach pain should only be done when a doctor advises.

Terms & Conditions

Sumo Tablet 15
Sumo Tablet 15
Alkem Laboratories Ltd.
Pack of 15 Units
MRP ₹149.00
18.00% OFF
Nimprex P Tablet 15
Nimprex P Tablet 15
Seagull Pharma
Pack of 15 Units
MRP ₹35.00
18.00% OFF
Nicip Plus Tablet 10
Nicip Plus Tablet 10
Cipla Ltd.
Pack of 10 Units
MRP ₹65.10
50.10% OFF
Lupisulide P Tablet 10
Lupisulide P Tablet 10
Lupin Ltd
Pack of 10 Units
MRP ₹65.75
50.10% OFF
Nodard Plus Tablet 10
Nodard Plus Tablet 10
Cipla Ltd.
Pack of 10 Units
MRP ₹57.75
50.10% OFF
Neopar Plus Tablet 10
Neopar Plus Tablet 10
Leeford Healthcare
Pack of 10 Units
MRP ₹29.90
50.10% OFF
Nimucet Tablet 10
Nimucet Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
MRP ₹58.50
50.10% OFF
Nimupara Dl Tablet 10
Nimupara Dl Tablet 10
Intas Pharmaceuticals Ltd
Pack of 10 Units
MRP ₹42.50
50.10% OFF


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