Home/Drugs By Ailments / Caffeine + Diphenhydramine + Paracetamol/acetaminophen + Phenylephrine

Caffeine + Diphenhydramine + Paracetamol/acetaminophen + Phenylephrine

Uses of Caffeine + Diphenhydramine + Paracetamol/acetaminophen + Phenylephrine

  • The combination of Caffeine + Diphenhydramine + Paracetamol/Acetaminophen + Phenylephrine is primarily used for relieving symptoms associated with the common cold, flu and allergies. This medication belongs to a group of medicines that includes decongestants, antihistamines, analgesics and a central nervous stimulant.

  • Apart from this, it can also provide relief from minor aches and pains not associated with cold or flu.

Side effects of Caffeine + Diphenhydramine + Paracetamol/acetaminophen + Phenylephrine

  • Drowsiness

  • Dizziness

  • Dry mouth

  • Restlessness or insomnia

  • Nausea and vomiting

How Caffeine + Diphenhydramine + Paracetamol/acetaminophen + Phenylephrine works

  • Caffeine is a stimulant that enhances the effect of Paracetamol/Acetaminophen. It boosts alertness and reduces fatigue by stimulating the central nervous system.

  • Diphenhydramine is an antihistamine. It helps alleviate allergy symptoms like a runny nose, sneezing, and itching by preventing histamine from binding to its receptors.

  • Paracetamol/Acetaminophen is an analgesic and antipyretic. It reduces pain and fever by inhibiting the synthesis of prostaglandins in the central nervous system.

  • Phenylephrine is a decongestant. It reduces swelling and congestion by narrowing the blood vessels in the nasal passages.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Osama Ahmed
Dr. Osama Ahmed Dental/Medical Writer, Editor, Reviewer| 2 years

Bachelor of Dental Surgery

Expert Advice

Dosage Forms Available

  • Caffeine + Diphenhydramine + Paracetamol/Acetaminophen + Phenylephrine is available as tablets, caplets, liqui-gels, and liquid suspensions for oral use.

Age and Dose Restrictions

  • This medicine is intended for adults and should not be given to children under the age of 12.

Contraindications

  • This medicine is contraindicated in patients with severe hypertension or coronary artery disease. It is also contraindicated in those suffering from narrow-angle glaucoma, urinary retention, or those who have taken a monoamine oxidase inhibitor (MAOI) within the past 14 days.

Other Medications to Avoid

  • This combination may interact with other decongestants (such as ibuprofen and pseudoephedrine), antihistamines (like cetirizine and loratadine), cough and cold medications (e.g, chlorpheniramine and brompheniramine), and MAOIs (e.g., selegiline, and tranylcypromine).

Overdose and Missed Dose

  • An overdose of this medication may cause symptoms such as severe dizziness, restlessness, nausea, vomiting, and increased heart rate. If you suspect an overdose, seek medical attention immediately.

  • If you miss a dose of this medicine, take it as soon as you remember. If it is close to the time for your next dose, skip the missed dose.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage dry mouth or throat caused by this medicine, drink plenty of water throughout the day.

  • If drowsiness occurs, adjust your dosage times to take the medicine when you do not need to be alert.

Use in Driving and Operating Machinery

  • This medicine may impair your ability to drive or operate heavy machinery due to its potential side effects, such as drowsiness or dizziness.

Use in Pregnancy and Lactation

  • The safety of this medication during pregnancy and lactation has not been established. It is advisable to consult your doctor before using this medication if you are pregnant or breastfeeding.

Caution in Other Conditions

  • Patients with liver disease or elevated blood pressure should use this medication with caution. Those with diabetes or thyroid disorders need to consult their doctor due to potential interactions with their existing medications and condition management.

Special Dietary and Lifestyle Recommendations

  • Increase your fluid intake to help alleviate any dehydration caused by fever or increased metabolic rate due to caffeine consumption.

  • Consider adopting a balanced diet rich in fruits, vegetables, and whole grains to support overall health and immune function while dealing with flu or cold symptoms.

  • Engage in moderate physical activity such as walking or stretching which may help boost your immune system and manage minor aches related to a cold or flu.

Frequently asked questions

No, this combination is not a steroid. It consists of a decongestant (Phenylephrine), an antihistamine (Diphenhydramine), a pain reliever and fever reducer (Paracetamol/Acetaminophen), and a central nervous system stimulant (Caffeine).

Before surgery, you should always inform your doctor about any medicines that you are taking, including over-the-counter medications like Caffeine + Diphenhydramine + Paracetamol/Acetaminophen + Phenylephrine.

Weight gain is not typically associated with this combination medication. However, each individual may react differently to medicines and it is best to discuss any concerns with your doctor.

It is generally recommended to avoid consuming alcohol while taking this combination as it could increase drowsiness and dizziness caused by Diphenhydramine, and may also increase the risk of liver damage from Paracetamol/Acetaminophen.

There is no known interaction between this combination medication and most birth control pills. However, always inform your doctor about all the medications you are currently taking to ensure there are no potential interactions.

If you experience symptoms of an allergic reaction such as rash, itching, difficulty breathing, or swelling of the face, lips, or throat after taking this medication, you should seek immediate medical attention.

If you have diabetes, consult your doctor before taking this combination medicine, as it may affect blood sugar levels.

Terms & Conditions


Caffeine + Diphenhydramine + Paracetamol/acetaminophen + Phenylephrine in other salts

ACECLOFENAC + PARACETAMOL/ACETAMINOPHENACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PARACETAMOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PHENYLEPHRINEAMMONIUM CHLORIDE + DIPHENHYDRAMINEPARACETAMOL + CAFFEINECHLORPHENIRAMINE MALEATE + PHENYLEPHRINE HYDROCHLORIDEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + RABEPRAZOLECHLORPHENIRAMINE + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PHENYLEPHRINEDEXTROPROPOXYPHENE + PARACETAMOL/ACETAMINOPHENCPM + DEXTROMETHORPHAN + PHENYLEPHRINELORNOXICAM + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDEXTROPROPOXYPHENE + DICYCLOMINE + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TRAMADOLDEXIBUPROFEN + PARACETAMOL/ACETAMINOPHENDICYCLOMINE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEDIPHENHYDRAMINECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINCHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINECAFFEINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEBECLOMETHASONE DIPROPIONATE + LIDOCAINE / LIGNOCAINE + PHENYLEPHRINECALCIUM DOBESILATE + HYDROCORTISONE + LIDOCAINE / LIGNOCAINE + PHENYLEPHRINE + TROXERUTIN + ZINC OXIDEPHENYLEPHRINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDEPARACETAMOL/ACETAMINOPHEN + RACEMETHIONINECARBOXY METHYL CELLULOSE + NAPHAZOLINE + PHENYLEPHRINENAPHAZOLINE + PHENYLEPHRINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECPM + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORBUTOL + PHENYLEPHRINE + TROPICAMIDECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMBROXOL + CHLORPHENIRAMINE + DEXTROMETHORPHAN + MENTHOL + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PHENYLEPHRINEBROMHEXINE + GUAIFENESIN + PHENYLEPHRINEAMMONIUM CHLORIDE + CITRIC ACID + DIPHENHYDRAMINE + MENTHOLBROMHEXINE + PHENYLEPHRINE + SALBUTAMOLAMMONIUM CHLORIDE + DIPHENHYDRAMINE + SODIUM CITRATEAMMONIUM CHLORIDE + DIPHENHYDRAMINE + MENTHOL + SODIUM CITRATEBENZALKONIUM CHLORIDE + PHENYLEPHRINE + TROPICAMIDEPHENYLEPHRINE + TROPICAMIDECAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDEBENZALKONIUM CHLORIDE + CAMPHOR + MENTHOL + NAPHAZOLINE HYDROCHLORIDE + PHENYLEPHRINE HYDROCHLORIDECALAMINE + CAMPHOR + DIPHENHYDRAMINEAMBROXOL + CHLORPHENIRAMINE + GUAIFENESIN + PHENYLEPHRINECALAMINE + DIPHENHYDRAMINE + ETHANOLCHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATECAMYLOFIN + PARACETAMOL/ACETAMINOPHENCHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATEPARACETAMOL/ACETAMINOPHEN + PROMETHAZINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PHENYLEPHRINE HYDROCHLORIDEDOMPERIDONE + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHENMETOCLOPRAMIDE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + FLUNARIZINE + PARACETAMOL/ACETAMINOPHENONDANSETRON + PARACETAMOL/ACETAMINOPHENAMBROXOL + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PHENYLEPHRINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINECHLORPHENIRAMINE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINECETIRIZINE + DEXTROMETHORPHAN + PHENYLEPHRINEBROMHEXINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + GUAIFENESIN + PHENYLEPHRINEDEXTROMETHORPHAN + PHENYLEPHRINE + TRIPROLIDINEAMBROXOL + CHLORPHENIRAMINE + GUAIFENESIN + MENTHOL + PHENYLEPHRINELEVOCETIRIZINE + PHENYLEPHRINEAMBROXOL + GUAIFENESIN + LEVOCETIRIZINE + PHENYLEPHRINEIBUPROFEN + MAGNESIUM TRISILICATE + PARACETAMOL/ACETAMINOPHENBROMHEXINE + DEXTROMETHORPHAN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PHENYLEPHRINE HYDROCHLORIDECETIRIZINE + DEXTROMETHORPHAN HYDROBROMIDE + PHENYLEPHRINE HYDROCHLORIDECETIRIZINE + DEXTROMETHORPHAN + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEAMBROXOL + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + MENTHOL + PHENYLEPHRINEAMBROXOL + CETIRIZINE + GUAIFENESIN + PHENYLEPHRINEAMMONIUM CHLORIDE + DIPHENHYDRAMINE + SODIUM CITRATE + TERPIN HYDRATEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TIZANIDINEPARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRAMADOLCHLORZOXAZONE + PARACETAMOL/ACETAMINOPHENCAFFEINE + IBUPROFEN + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLPARACETAMOL/ACETAMINOPHEN + TAPENTADOLDICYCLOMINE + PAMABROM + PARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASECAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECETIRIZINE + PHENYLEPHRINEASPIRIN + CAFFEINEDICLOFENAC + METHOCARBAMOL + PARACETAMOL/ACETAMINOPHENHYOSCINE + PARACETAMOL/ACETAMINOPHENETORICOXIB + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINFEXOFENADINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECODEINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHENDICLOFENAC + DICYCLOMINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENAZONEBROMHEXINE + CPM + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDEXTROPROPOXYPHENE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENDROTAVERINE + PARACETAMOL/ACETAMINOPHENDICYCLOMINE + MEFENAMIC ACID + PARACETAMOL/ACETAMINOPHENETODOLAC + PARACETAMOL/ACETAMINOPHENLORNOXICAM + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TIZANIDINEDEXKETOPROFEN + PARACETAMOL/ACETAMINOPHENBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENAMBROXOL + LEVOCETIRIZINE + PHENYLEPHRINECHLORZOXAZONE + DICLOFENAC SODIUM + PARACETAMOL/ACETAMINOPHENCAFFEINE + CETIRIZINE + NIMESULIDE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + IBUPROFEN + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TOLPERISONECAFFEINE + CETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDEXTROPROPOXYPHENE + DICLOFENAC + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + PROCHLORPERAZINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + ERGOTAMINE + PARACETAMOL/ACETAMINOPHEN + PROCHLORPERAZINELEVOCETIRIZINE + NIMESULIDE + PHENYLEPHRINEPARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEAMBROXOL + CETIRIZINE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + CETIRIZINE + NIMESULIDE + PHENYLEPHRINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN
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