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Domperidone + Paracetamol/acetaminophen + Tramadol

Uses of Domperidone + Paracetamol/acetaminophen + Tramadol

  • Domperidone + Paracetamol/Acetaminophen + Tramadol is mainly used for the short-term management of moderate to severe acute pain requiring an opioid analgesic, and is part of the combination analgesic class of medicines.

  • Secondary uses include the management of postoperative pain, dental pain, headache, musculoskeletal pain, and pain associated with trauma or injury.

Side effects of Domperidone + Paracetamol/acetaminophen + Tramadol

  • Nausea

  • Vomiting

  • Constipation

  • Dizziness

  • Drowsiness

How Domperidone + Paracetamol/acetaminophen + Tramadol works

  • Domperidone + Paracetamol/Acetaminophen + Tramadol is a combination used for managing pain, often with nausea relief.

  • Domperidone is an antiemetic. It works by countering the actions of a substance called dopamine in the brain, which causes feelings of sickness (nausea) and prevents vomiting. It also promotes movement in the digestive system, further reducing the feeling of sickness.

  • Paracetamol/Acetaminophen is an analgesic and antipyretic. It helps to reduce pain and fever. It does this by blocking certain enzymes in the body that make prostaglandins. Lowering the levels of prostaglandins helps reduce pain and fever.

  • Tramadol is an opioid analgesic used to manage moderate to severe pain. It works by binding to specific receptors in the brain called opioid receptors, which block pain signals from reaching the brain. Tramadol also affects neurotransmitters like norepinephrine and serotonin, enhancing the body's natural pain-relief mechanisms.

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Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Domperidone + Paracetamol/Acetaminophen + Tramadol is available for oral administration (tablets).

Age and Dose Restrictions

  • This combination medication is intended for use in adults and children over 12 years of age.

Contraindications

  • Domperidone + Paracetamol/Acetaminophen + Tramadol is contraindicated in patients with hypersensitivity to any of the ingredients, acute intoxication with alcohol, hypnotics, centrally acting analgesics, opioids or psychotropic medications, severe respiratory depression, severe bronchial asthma, gastrointestinal obstruction, and raised intracranial pressure.

Other Medications to Avoid

  • This combination may interact with CNS depressants (such as diazepam), serotonergic medicines (such as SSRIs like sertraline and SNRIs like venlafaxine), antifungals (including ketoconazole), and opioid medications (like morphine and fentanyl).

Overdose and Missed Dose

  • Overdose of this combination can lead to severe respiratory depression, extreme drowsiness progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, slow heart rate, and low blood pressure. In such a case, immediate medical attention is needed.

  • If you forget to take a dose of this medicine, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose. Do not take a double dose to make up for a forgotten tablet.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • Drinking plenty of water can help manage some side effects like constipation.

  • Taking the medication with food can help manage nausea.

Use in Driving and Operating Machinery

  • Domperidone + Paracetamol/Acetaminophen + Tramadol may affect your ability to drive or operate heavy machinery. Avoid driving or operating machinery if you feel dizzy, tired, or have problems with your vision after taking this medication.

Use in Pregnancy and Lactation

  • Domperidone + Paracetamol/Acetaminophen + Tramadol may cause harm to the foetus and is excreted in breast milk. Therefore, it is not recommended for use during pregnancy and lactation unless advised by a doctor.

Caution in Other Conditions

  • Patients with severe hepatic impairment should exercise caution when taking this medicine. Dose adjustment may be necessary. Patients with renal impairment should also take caution as there is an increased risk of adverse reactions. Dose reduction may be required for those with creatinine clearance less than 30 mL/min.

Special Dietary and Lifestyle Recommendations

  • Maintaining a healthy diet balanced in fibre can help manage constipation which is a common side effect of this medication.

  • Engaging in regular physical activity (within personal limits) can help manage pain and improve overall well-being.

  • Regular sleep patterns and stress management techniques can also contribute to better pain management.

Frequently asked questions

Domperidone + Paracetamol/Acetaminophen + Tramadol has the potential to affect the central nervous system, which may lead to mood changes in some individuals. Always consult your doctor if you experience any unusual changes in mood or behaviour.

It is generally not advisable to abruptly stop taking Domperidone + Paracetamol/Acetaminophen + Tramadol, especially if it is being used for pain management. Always consult your doctor for advice on how to safely stop this medicine.

The components of the medicine are suitable for vegetarians and vegans since they are chemical compounds, but the capsule or tablet coating could have animal-derived ingredients. It is best to check with the pharmaceutical company or consult your doctor.

As one of the components, Tramadol, is an opioid analgesic, there is a potential risk of dependency and withdrawal symptoms with prolonged use. It is essential to use this medication under the supervision of a doctor.

While some natural remedies may help manage mild pain, this combination medication provides relief from moderate to severe acute pain. Always consult your doctor before substituting this medicine with natural alternatives.

Domperidone + Paracetamol/Acetaminophen + Tramadol does not typically interfere with hormonal balance. However, long-term use and individual health conditions may influence this. Always discuss any concerns with your doctor.

Off-label use of any medication should be strictly under the supervision and advice of a doctor. It is recommended not to use this medication for any purpose other than what it has been prescribed for.

Terms & Conditions


Domperidone + Paracetamol/acetaminophen + Tramadol in other salts

ACECLOFENAC + PARACETAMOL/ACETAMINOPHENACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + OMEPRAZOLEDOMPERIDONE + RABEPRAZOLEPARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + ESOMEPRAZOLENIMESULIDE + PARACETAMOL/ACETAMINOPHENDOMPERIDONENAPROXEN + DOMPERIDONETRAMADOLACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + RABEPRAZOLEDEXRABEPRAZOLE + DOMPERIDONEDEXTROPROPOXYPHENE + PARACETAMOL/ACETAMINOPHENCINNARIZINE + DOMPERIDONEDOMPERIDONE + ILAPRAZOLEDOMPERIDONE + LAFUTIDINEDOMPERIDONE + LANSOPRAZOLELORNOXICAM + PARACETAMOL/ACETAMINOPHENNIMESULIDE + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDEXTROPROPOXYPHENE + DICYCLOMINE + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TRAMADOLDEXIBUPROFEN + PARACETAMOL/ACETAMINOPHENDICYCLOMINE + PARACETAMOL/ACETAMINOPHEN + TRAMADOLDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEDOMPERIDONE + RANITIDINECAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINCAFFEINE + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDEPARACETAMOL/ACETAMINOPHEN + RACEMETHIONINECETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECPM + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDOMPERIDONE + SUCRALFATECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATEDOMPERIDONE + MAGALDRATE + SIMETHICONECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDE + SODIUM CITRATECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECHLORPHENIRAMINE MALEATE + MENTHOL + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATECAMYLOFIN + PARACETAMOL/ACETAMINOPHENCHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE + SODIUM CITRATEPARACETAMOL/ACETAMINOPHEN + PROMETHAZINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORPHENIRAMINE MALEATE + DEXTROMETHORPHAN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDOMPERIDONE + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLPROPANOLAMINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEAMBROXOL + LEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHENMETOCLOPRAMIDE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + FLUNARIZINE + PARACETAMOL/ACETAMINOPHENDOMPERIDONE + RANITIDINE + SIMETHICONEONDANSETRON + PARACETAMOL/ACETAMINOPHENLEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PSEUDOEPHEDRINEBROMHEXINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEIBUPROFEN + MAGNESIUM TRISILICATE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TIZANIDINEPARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEACECLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRAMADOLCHLORZOXAZONE + PARACETAMOL/ACETAMINOPHENCAFFEINE + IBUPROFEN + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TAPENTADOLDICYCLOMINE + PAMABROM + PARACETAMOL/ACETAMINOPHENIBUPROFEN + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASECAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECAFFEINE + DIPHENHYDRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDICLOFENAC + METHOCARBAMOL + PARACETAMOL/ACETAMINOPHENHYOSCINE + PARACETAMOL/ACETAMINOPHENETORICOXIB + PARACETAMOL/ACETAMINOPHENCETIRIZINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TRYPSIN-CHYMOTRYPSINFEXOFENADINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECODEINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE + PARACETAMOL/ACETAMINOPHENDICLOFENAC + DICYCLOMINE + PARACETAMOL/ACETAMINOPHENCAFFEINE + PARACETAMOL/ACETAMINOPHEN + PHENAZONEBROMHEXINE + CPM + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDEXTROPROPOXYPHENE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENDICLOFENAC + TRAMADOLDROTAVERINE + PARACETAMOL/ACETAMINOPHENDICYCLOMINE + MEFENAMIC ACID + PARACETAMOL/ACETAMINOPHENETODOLAC + PARACETAMOL/ACETAMINOPHENLORNOXICAM + PARACETAMOL/ACETAMINOPHEN + SERRATIOPEPTIDASEDICLOFENAC + PARACETAMOL/ACETAMINOPHEN + TIZANIDINEDEXKETOPROFEN + PARACETAMOL/ACETAMINOPHENBROMHEXINE + CHLORPHENIRAMINE MALEATE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + NIMESULIDE + PARACETAMOL/ACETAMINOPHENCHLORZOXAZONE + DICLOFENAC SODIUM + PARACETAMOL/ACETAMINOPHENCAFFEINE + CETIRIZINE + NIMESULIDE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINECHLORZOXAZONE + IBUPROFEN + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + TOLPERISONECAFFEINE + CETIRIZINE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINEDEXTROPROPOXYPHENE + DICLOFENAC + PARACETAMOL/ACETAMINOPHENPARACETAMOL/ACETAMINOPHEN + PROCHLORPERAZINECHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHENCAFFEINE + CHLORPHENIRAMINE MALEATE + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINE HYDROCHLORIDECAFFEINE + ERGOTAMINE + PARACETAMOL/ACETAMINOPHEN + PROCHLORPERAZINEPARACETAMOL/ACETAMINOPHEN + THIOCOLCHICOSIDEAMBROXOL + CETIRIZINE + GUAIFENESIN + PARACETAMOL/ACETAMINOPHEN + PHENYLEPHRINELEVOCETIRIZINE + PARACETAMOL/ACETAMINOPHEN
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