Diclofenac + Paracetamol + Tizanidine is a combination medicine used to relieve pain and muscle spasm associated with musculoskeletal conditions.
This combination is commonly used for:
• Acute back pain: Relieves pain and muscle spasm associated with lower back conditions.
• Muscle spasm: Eases tightness and spasm in skeletal muscles caused by injury or musculoskeletal disorders.
• Osteoarthritis and joint pain: Reduces pain and inflammation associated with joint conditions.
• Post-injury or post-surgical pain: Helps manage pain and muscle tightness following minor injuries or procedures.
• Cervical spondylosis: Relieves neck pain and associated muscle spasm.
Diclofenac + Paracetamol + Tizanidine works through three separate mechanisms to relieve pain, inflammation, and muscle spasm together.
Diclofenac is a nonsteroidal anti-inflammatory drug (NSAID). It blocks enzymes called cyclooxygenases (COX), which reduces the production of prostaglandins, chemicals responsible for causing pain, inflammation, and swelling.
Pracetamol is a pain reliever and fever reducer. It acts on the brain's pain and temperature-regulating centres to reduce the perception of pain and lower fever.
Tizanidine is a muscle relaxant. It acts on the central nervous system to reduce the excessive nerve signals that cause muscles to tighten, easing muscle spasm and stiffness.
Together, these three ingredients relieve pain and inflammation whilst directly easing muscle spasm, making the combination effective for musculoskeletal pain accompanied by muscle tightness.

Doctor of Medicine

BAMS, FMC, MD Resident
Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.
Frequently asked questions
No, this combination is not a steroid. It consists of Diclofenac, an anti-inflammatory medicine, Paracetamol / Acetaminophen, a pain reliever and fever reducer, and Tizanidine, a muscle relaxant.
Tizanidine, one of the components of this combination, can cause some side effects on the central nervous system, such as dizziness and somnolence, which might potentially affect your mood. If you experience any significant mood changes while taking this medicine, consult your doctor.
If you are allergic to any of the three components in this combination or other NSAIDs, you should not take this medication. Always let your doctor know about your allergies before starting any new medication.
The pain-relieving effect of this combination medicine begins within 20-30 minutes of taking the tablets. However, maximum effects are usually seen within a few days of regular dosing.
This combination should be used at the lowest effective dose for the shortest possible duration to minimise the risk of side effects. Long-term use can lead to serious gastrointestinal, cardiovascular, liver and blood-related side effects.
Diclofenac may affect fertility in some individuals, especially with long-term use. There is no strong evidence suggesting that Paracetamol or Tizanidine affects fertility. If you have concerns, consult your doctor for personalized advice.
This combination can cause drowsiness and insomnia as side effects. If these effects persist or become bothersome, consult your doctor.
Diclofenac + Paracetamol/Acetaminophen + Tizanidine in other salts
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