Sacu V 50 Tablet 14

Sacu-V 50 Tablet is used in adults and children over one year with chronic HFrEF to reduce cardiovascular death and hospitalisation.

Uses of Sacu-V 50 Tablet are:

• Chronic HFrEF: Reduces cardiovascular death and hospitalisation in heart failure with reduced ejection fraction.

To properly administer Sacu-V 50 Tablet, follow these steps:

• Swallow the tablet whole with a glass of water.

• Avoid crushing or chewing the tablet, as it may affect how well it works.

• The tablet can be taken with or without food, depending on your preference.

• Do not take more than your doctor has prescribed. If you have any doubts about the dosage, consult your doctor for guidance.

Sacu-V 50 Tablet is taken orally.

Sacu-V 50 Tablet consists of two active ingredients:

• Sacubitril (24 mg): This component is a prodrug that is metabolised into LBQ657, an inhibitor of an enzyme called neprilysin. Neprilysin is responsible for breaking down several vasoactive substances, including natriuretic peptides and bradykinin. By inhibiting neprilysin, sacubitril elevates the levels of these peptides, enhancing their beneficial effects on cardiovascular and renal health.

• Valsartan (26 mg): As an angiotensin II receptor blocker (ARB), valsartan impedes the actions of angiotensin II on the AT1 receptor. This action reduces vasoconstriction, sodium and water retention, cardiac hypertrophy, and fibrosis.

Together, these ingredients result in vasodilation, decreased sodium and water retention, reduced cardiac workload, and inhibited cardiac remodelling. These combined effects contribute to improved cardiac function and reduced hospitalisation and mortality rates among heart failure patients.

• Store Sacu-V 50 Tablet in a cool and dry place, ideally at a temperature not exceeding 30°C.

• Keep the product protected from light and moisture to maintain its effectiveness.

• Always ensure Sacu-V 50 Tablet is kept out of reach of children.

• Use the medicine before its expiry date for optimal results.

• As Sacu-V 50 Tablet is used to manage heart failure, ensure you follow a low-sodium diet. Excessive salt can lead to fluid retention and worsening heart conditions.

• Engage in regular mild to moderate physical activity as recommended by your doctor. It helps strengthen your heart muscles, contributing to better heart health.