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Sacu-V 50 Tablet is used to treat chronic heart failure in adults and children (over one year old). Containing sacubitril and valsartan, it reduces the risk of cardiovascular death and hospitalisation. It works with other heart failure therapies to improve survival and alleviate clinical symptoms in patients with a weak heart pumping action.
Sacu-V 50 Tablet is used for managing symptomatic chronic heart failure with reduced ejection fraction (HFrEF). Its primary goals are reducing the risk of cardiovascular death and decreasing hospitalisation due to heart failure. This combination drug (Sacubitril/Valsartan, an ARNI) works by enhancing protective neurohormonal systems. It is often used in place of ACE inhibitors or other Angiotensin II Receptor Blockers (ARBs) in certain heart failure patients.
To properly administer Sacu-V 50 Tablet, follow these steps:
Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet, as it may affect how well it works.
The tablet can be taken with or without food, depending on your preference.
Do not take more than your doctor has prescribed. If you have any doubts about the dosage, consult your doctor for guidance.
Sacu-V 50 Tablet is taken orally.
Sacu-V 50 Tablet may cause side effects such as low blood pressure, high potassium levels, cough, dizziness, or kidney-related issues. If these side effects persist or worsen, consult your doctor.
Most side effects are temporary and generally harmless, and they resolve when you discontinue using Sacu-V 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Hypotension: If Sacu-V 50 Tablet is causing low blood pressure, consider taking it in the evening.
Dizziness: If you feel dizzy after taking this medicine, try taking it before bedtime.
Sacu-V 50 Tablet consists of two active ingredients:
Sacubitril (24 mg): This component is a prodrug that is metabolised into LBQ657, an inhibitor of an enzyme called neprilysin. Neprilysin is responsible for breaking down several vasoactive substances, including natriuretic peptides and bradykinin. By inhibiting neprilysin, sacubitril elevates the levels of these peptides, enhancing their beneficial effects on cardiovascular and renal health.
Valsartan (26 mg): As an angiotensin II receptor blocker (ARB), valsartan impedes the actions of angiotensin II on the AT1 receptor. This action reduces vasoconstriction, sodium and water retention, cardiac hypertrophy, and fibrosis.
Together, these ingredients result in vasodilation, decreased sodium and water retention, reduced cardiac workload, and inhibited cardiac remodelling. These combined effects contribute to improved cardiac function and reduced hospitalisation and mortality rates among heart failure patients.
Sacu-V 50 Tablet should be discontinued as soon as pregnancy is detected, particularly during the 2nd and 3rd trimesters, which may cause harm to the developing foetus. It's best to consult your doctor before taking this medicine if you are pregnant or planning to conceive.
No specific information is available about the use of Sacu-V 50 Tablet during breastfeeding. Hence, caution is advised while taking this medicine if you are nursing. Always consult your doctor before taking this medication.
The interaction of Sacu-V 50 Tablet with alcohol is unknown. It's best to discuss with your doctor about consumption of alcohol while taking this medicine.
Sacu-V 50 Tablet can be taken by patients with mild to moderate liver impairment. However, caution is advised if you have severe liver problems. Consult your doctor before starting this medicine.
If you have a history of kidney problems, consult your doctor before taking Sacu-V 50 Tablet. Your kidney function may need close monitoring while using this medicine.
The effect of Sacu-V 50 Tablet on your ability to drive or operate machinery is not known. If you feel dizzy or unwell after taking this medicine, avoid driving or operating heavy machinery until you feel better.
Do not take Sacu-V 50 Tablet if you have a history of angioedema or are allergic to sacubitril, valsartan, or any other ingredients. Before starting this medicine, let your doctor know about any allergies.
Sacu-V 50 Tablet is meant for adults and is not recommended for children under 18 years of age. Always consult with your doctor before giving any medication to a child.
Older patients may be more susceptible to the side effects of Sacu-V 50 Tablet. If you are above 70 years of age, take this medicine under medical supervision. Your doctor will guide you based on your overall health status.
ACE inhibitors and ARBs: Combining Sacu-V 50 Tablet with ACE inhibitors (like enalapril or lisinopril) or another ARB (like losartan) could amplify the risk of hypotension, hyperkalaemia, and renal impairment.
Direct Renin Inhibitors: If you're using aliskiren, a direct renin inhibitor, it could interact with Sacu-V 50 Tablet, causing similar effects as above.
NSAIDs: Nonsteroidal anti-inflammatory drugs such as ibuprofen can reduce blood pressure, lowering the effect of Sacu-V 50 tablets and potentially worsening renal function.
Potassium Supplements and Potassium-Sparing Diuretics: These can significantly increase serum potassium when used in conjunction with Sacu-V 50 Tablet.
Lithium: This medicine's levels can rise if taken alongside Sacu-V 50 Tablet, potentially leading to lithium toxicity.
No specific food items are known to interact significantly with Sacu-V 50 Tablet. However, maintaining a balanced diet is always beneficial for overall health.
Sacu-V 50 Tablet interacts with the following diseases:
Renal Impairment: If you have kidney problems, this medicine may worsen your condition. Regular monitoring of kidney function is advised during its use.
Liver Disease: Patients suffering from liver disease should be cautious while using Sacu-V 50 Tablet as its metabolism could be affected.
Diabetes: Since this medicine may increase potassium levels, it could impact blood sugar control in diabetic patients. Regular monitoring of blood sugar levels is recommended.
Remember, the daily dose of Sacu-V 50 Tablet should be taken as directed by your doctor. The dosage might vary depending on factors like the severity of your condition and your response to treatment. Always stick to the prescribed dosage and don't exceed it without discussing it with your doctor.
If you accidentally take more Sacu-V 50 Tablets than recommended, you might experience symptoms like dizziness or lightheadedness. In such cases, it would be wise to inform your doctor about your situation.
If you miss a dose, take it as soon as you remember. But if it's nearly time for your next dose, leave out the missed one and continue with your usual schedule. Don't double up on doses without consulting with your doctor.
Store Sacu-V 50 Tablet in a cool and dry place, ideally at a temperature not exceeding 30°C.
Keep the product protected from light and moisture to maintain its effectiveness.
Always ensure Sacu-V 50 Tablet is kept out of reach of children.
Use the medicine before its expiry date for optimal results.
As Sacu-V 50 Tablet is used to manage heart failure, ensure you follow a low-sodium diet. Excessive salt can lead to fluid retention and worsening heart conditions.
Engage in regular mild to moderate physical activity as recommended by your doctor. It helps strengthen your heart muscles, contributing to better heart health.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Chronic Heart Failure, Cardiovascular Risk Reduction |
| Drug Category | Neprilysin Inhibitor, Angiotensin II Receptor Blocker |
| Therapeutic Category | Heart Failure Management |
Sacu-V 50 Tablet is used to manage chronic heart failure, reducing the risk of cardiovascular death and frequent hospitalisations.
Sacu-V 50 Tablet contains sacubitril and valsartan, which work together to improve heart function by enhancing beneficial peptides and blocking the detrimental effects of certain hormones.
Yes, Sacu-V 50 Tablet can be taken with or without food. It should be swallowed whole with water and not crushed or chewed.
Pregnant women should avoid using Sacu-V 50 Tablet as it can cause harm to the developing baby, especially during the second and third trimesters.
The most common side effects include low blood pressure, high blood potassium levels, cough, dizziness, and kidney problems.
Yes, it can interact with ACE inhibitors, ARBs, renin inhibitors, potassium-sparing diuretics, NSAIDs, and lithium. Always consult your doctor before starting any new medication.
Store this medicine at room temperature (25°C), away from light and moisture, and out of the reach of children.
Check out Editorial Policy
U.S. Food and Drug Administration. (2015). FDA Drug Safety Communication: FDA warns about new impulse control problems associated with mental health drug aripiprazole (Abilify, Abilify Maintena, Aristada). Retrieved from https://www.fda.gov/media/134841/download on 1 April 2024.
Nicolas D, Kerndt CC, Patel P, et al. (2022, May 26). Sacubitril-valsartan - StatPearls - NCBI bookshelf. National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK507904/
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