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CompositionSacuval 50 Tablet is used to manage chronic heart failure and reduced ejection fraction in adults.
This medication helps improve heart function, reduces the strain on the heart, and lowers the risk of cardiovascular death and hospitalization due to heart failure. By supporting the heart’s performance, it contributes to better overall heart health and minimizes complications.
Sacuval 50 Tablet is used to manage chronic heart failure. This medicine helps relax blood vessels, improve blood circulation, and reduce the workload on the heart, which can prevent complications and lower the risk of hospitalization.
Swallow the tablet whole with a glass of water. Don't break, crush or chew it.
Don't take more than what your doctor has recommended.
It's important not to stop taking this medicine without consulting your doctor first. If you have doubts or concerns, consult your doctor.
Sacuval 50 Tablet is taken orally.
Sacuval 50 Tablet may cause some common side effects, including low blood pressure, elevated potassium levels, dizziness, persistent cough, and potential kidney issues. Most side effects are manageable, but it is important to consult a doctor if any of these symptoms occur.
Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Sacuval 50 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some tips for managing common side effects:
Low blood pressure and dizziness: If you feel dizzy or faint after taking this medicine, try sitting down until it passes.
Kidney problems: Ensure to stay well hydrated by drinking plenty of water daily.
Sacuval 50 Tablet achieves its therapeutic effects through two active ingredients:
Sacubitril (24 mg): This ingredient inhibits an enzyme called neprilysin in your body. Neprilysin is responsible for breaking down peptides that relax blood vessels and eliminate sodium and fluid. By inhibiting neprilysin, sacubitril increases these peptides, leading to lower blood pressure and reduced strain on the heart.
Valsartan (26 mg): Valsartan is an angiotensin II receptor blocker. Angiotensin II is a substance that narrows blood vessels, increasing blood pressure and making the heart work harder. By blocking the action of angiotensin II, valsartan helps relax blood vessels and lower blood pressure, thereby reducing the workload on the heart.
Sacuval 50 Tablet could potentially harm a foetus if taken during pregnancy. It should be discontinued as soon as pregnancy is detected.
The effects of Sacuval 50 Tablet on breastfeeding mothers are unclear. Therefore, it's best to consult your doctor before taking this medicine while lactating.
Caution is advised when consuming alcohol during the medication period.
If you have severe liver impairment, it is not recommended to use Sacuval 50 Tablet. Discuss your liver health history with your doctor before starting this medication.
Sacuval 50 Tablet may affect kidney function, and caution is advised if you have a history of kidney problems. Your doctor will guide you based on your health status.
There's no specific information about whether Sacuval 50 Tablet affects your ability to drive or operate machinery. If you feel dizzy or unwell after taking this medicine, avoid such activities until you feel better.
This medicine is contraindicated for patients allergic to sacubitril, valsartan or any other ingredients in the tablet. Consult your doctor if you have a history of allergies.
The safety and effectiveness of Sacuval 50 Tablet in children are not known. Always consult your doctor before giving this medicine to a child.
Older patients should use Sacuval 50 Tablet under medical supervision as they may be more susceptible to its side effects. If you are above 70 years of age, discuss your health status with your doctor before starting this medication.
Sacuval 50 Tablet interacts with the following medicines:
ACE inhibitors: Medicines such as enalapril or lisinopril can increase the risk of angioedema if taken along with Sacuval 50 Tablet.
Potassium Supplements: These can raise potassium levels in your blood (hyperkalemia) when taken with Sacuval 50 Tablet.
NSAIDs: Medicines like ibuprofen and naproxen could reduce the blood pressure-lowering effect of Sacuval 50 Tablet and increase the risk of kidney dysfunction.
Statins: Medicines like atorvastatin or simvastatin have increased exposure when taken with Sacuval 50 Tablet.
There are no known food interactions with Sacuval 50 Tablet.
Sacuval 50 Tablet interacts with the following diseases:
Liver disease: Patients with severe liver impairment should be cautious while taking this medication as it may worsen their condition.
Diabetes: If you are diabetic and taking Aliskiren, you should not use Sacuval 50 Tablet as it could lead to an increased risk of hyperkalemia, hypotension and kidney dysfunction.
The daily dose of Sacuval 50 Tablet should be as prescribed by your doctor. This dosage may vary based on factors such as your health condition and how you respond to the medicine. It's crucial to follow the prescribed dosage and not exceed it without consulting your doctor.
An overdose of Sacuval 50 Tablet may lead to symptoms similar to its side effects, such as low blood pressure or high potassium levels in the blood. If you suspect an overdose, it is important to inform your doctor.<Put in information about what to do in case of an overdose.>
If you forget to take a dose of Sacuval 50 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Never increase your dosage without consulting with your doctor.
Keep Sacuval 50 Tablet in its original packaging.
Store at a temperature below 30°C.
Protect the medicine from moisture.
Always keep out of reach of children.
Ensure to use the medicine before its expiry date.
Consuming too much salt can raise your blood pressure, making heart failure worse. Try to stick to a low-sodium diet to improve your heart health while taking Sacuval 50 Tablet.
Regular gentle exercise can help strengthen your heart. Consult your doctor for advice on what kind and how much exercise is right for you whilst managing your condition with Sacuval 50 Tablet.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Chronic Heart Failure, Reduced Ejection Fraction |
| Drug Category | Neprilysin Inhibitor, Angiotensin II Receptor Blocker |
| Therapeutic Category | Antihypertensive |
Sacuval 50 Tablet is used to manage chronic heart failure and reduce the risk of cardiovascular death and hospitalisation for heart failure.
It contains sacubitril and valsartan, which together relax blood vessels, improve blood flow, reduce the heart's workload, and decrease stress on the heart.
You must take the medicine as directed by your doctor.
If you experience side effects such as low blood pressure, high potassium levels or kidney problems, promptly report these symptoms to your doctor.
No, Sacuval can harm the fetus if taken during pregnancy. Discontinue as soon as pregnancy is detected and consult your doctor.
Yes, but avoid taking it with aliskiren if you are diabetic. Regularly monitor your blood sugar levels.
It starts working soon after taking it but full effects may take several weeks. Don't stop taking it without consulting your doctor.
Check out Editorial Policy
Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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