Eptus 25 Tablet 15

Glenmark Pharmaceuticals Ltd.

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Composition

Eplerenone (25 Mg)

Eptus 25 Tablet is a diuretic, also known as a water pill, primarily used to treat hypertension (high blood pressure) and heart failure. It helps reduce swelling (edema) caused by various conditions. Eptus 25 can be taken alone or in combination with other medications, such as ACE inhibitors or beta-blockers, to effectively control blood pressure.

After oral administration, Eptus 25 is rapidly absorbed and reaches maximum plasma concentrations within 1-2 hours. It is metabolized in the liver and excreted mainly in the feces, helping maintain the body’s fluid balance and support cardiovascular health.

Eptus 25 tablet can also cause dizziness or lightheadedness, especially during the initial days of treatment. Therefore, Patients should follow their healthcare provider's instructions for taking the medication and promptly report any side effects or concerns.

However, Eptus 25 mg tablet has been shown to improve heart function and reduce hospitalisations for heart failure in these patients.

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Uses of Eptus 25 Tablet: Eptus 25 Tablet manages hypertension by increasing urine flow to lower blood pressure, reducing the risk of strokes and heart attacks. It also treats edema by removing excess fluid and alleviating swelling, and it helps manage heart failure by improving blood flow and easing symptoms like breathlessness. Regular use is important, so consult your doctor before stopping.

Directions for Use of Eptus 25 Tablet 15

It would be best to inform your healthcare provider of any medical conditions and medications you are taking.
Eptus 25 mg tablet is a medication that should be taken as directed by a healthcare provider.
Eptus 25 tablet should be swallowed whole with a glass of water and not crushed or chewed.

The route of administration for the Eptus 25 tablet is oral.

Some of the side effects of Eptus 25:

Headache: Headache is a common side effect of Eptus 25. It may occur due to the medication's vasodilatory effect on blood vessels.
Dizziness: Dizziness is another common side effect of Eptus 25. It may be due to the medication's ability to lower blood pressure.
Fatigue: Eptus 25 may cause fatigue or tiredness, affecting the central nervous system.
Hyperkalemia: Eptus 25 may cause an increase in serum potassium levels, which can lead to hyperkalemia. Patients should have their serum potassium levels monitored while taking Eptus 25.
Nausea and vomiting: In some patients, Eptus 25 may cause nausea and vomiting. These symptoms are usually mild and short-term and do not require medication discontinuation. Patients may benefit from taking Eptus 25 with food to reduce the risk of nausea and vomiting.
Diarrhoea: Eptus 25 may cause diarrhoea in some patients. Patients should be advised to report any persistent or severe diarrhoea to their healthcare provider.
Increased creatinine levels in the blood: Eptus 25 may cause an increase in creatinine levels in the blood, which can indicate impaired kidney function.
Cough: Cough is another common respiratory side effect of Eptus 25. It is usually dry and nonproductive and can be caused by the medication's effects on the lungs or throat.

Managing the Side Effects:

Some natural remedies may help alleviate some of the side effects of the Eptus 25 tablet. Here are some potential options:

Dizziness: Ginger and peppermint tea may help alleviate dizziness and improve digestion. However, they should not be used excessively as they may cause stomach upset.
Diarrhoea: Probiotics such as yoghourt or kefir may help restore gut flora and alleviate diarrhoea. Chamomile tea may also help soothe the digestive tract.
Nausea: Ginger is a well-known natural remedy for nausea. It can be consumed as a tea or in capsule form.
Cough: Honey and lemon tea may help soothe coughs and sore throats. Eucalyptus oil may also be helpful when inhaled in a diffuser.
Fatigue: Ginseng and ashwagandha are two herbs that may help improve energy levels and reduce fatigue.
Increased potassium level in blood: Foods rich in potassium, such as bananas, sweet potatoes, and spinach, should be avoided or consumed in moderation if you have increased potassium levels in your blood.
Increased creatinine level in blood: Drinking plenty of water may help flush out excess creatinine in the blood. Eating a balanced diet and avoiding high-protein foods may also help.
Headache: Take plenty of rest and have a lot of water to stay hydrated. Massage with coconut oil may also be helpful when applied topically.

However, natural or herbal management of side effects should always be discussed with a healthcare provider before trying, as they may interact with medications and cause adverse effects.

Eptus 25 mg tablet is a medication that contains the active ingredient eplerenone, which belongs to a class of medications called aldosterone antagonists. Eplerenone selectively blocks the effects of aldosterone, a hormone the adrenal glands produce that regulates sodium and potassium levels in the body.

Aldosterone elevates sodium reabsorption and potassium excretion in the kidneys, which can lead to fluid retention and elevated blood pressure. By blocking aldosterone's effects, Eptus 25 helps to reduce sodium and water retention in the body and lower blood pressure.

Pregnancy

Eptus 25 mg Tablet use in pregnancy is not suggested since insufficient research has been conducted to determine its safety. Your doctor will only prescribe this medication if the possible benefits outweigh the risks.

Breastfeeding

It is unknown whether Eptus 25 tablet passes into breast milk. Therefore, it is not recommended to use this medication during breastfeeding. If a woman needs to take this medication while breastfeeding, she should consult her healthcare provider.

Alcohol

It is not recommended to consume alcohol while taking Eptus 25 tablet as it may raise the likelihood of side effects such as dizziness and lightheadedness.

Liver

Eptus 25 mg Tablet is not advised if you have liver problems or if your liver function tests show abnormalities. Eptus 25 mg tablet is metabolised in your liver, and pre-existing liver issues can cause a buildup, resulting in severe liver damage.

Kidney

Eptus 25 tablet should be used cautiously in patients with kidney problems. Based on the severity of the condition, the dosage may need to be changed, and periodic kidney function tests may be necessary.

Using Machines & Driving

Eptus 25 tablet may lead to dizziness and drowsiness, impairing your capability to drive or operate machinery. It would be best to avoid such activities until they know how Eptus 25 tablet affects them.

Allergy

Patients with a known allergy to any ingredients in Eptus 25 tablet should not use this medication.

Children

The safety and efficacy of Eptus 25 tablet have not been established. Therefore, it is not recommended for use in children.

Older Patients

Older individuals can take Eptus 25 pill; however, the dosage may need to be changed due to changes in kidney function caused by ageing.

Drug-Drug Interactions

The Eptus 25 can interact with Medications, including:

Anti-fungal medications like Itraconazole or ketoconazole; fluconazole is used to treat fungal infections
Antiviral medications such as ritonavir and nelfinavir are used to treat HIV.
Antibiotics such as Erythromycin, clarithromycin, telithromycin, and rifampicin treat bacterial infections.
Anti-depressants such as nefazodone used to treat depression can interact with Eptus 25 tablet as these drugs reduce the breakdown of Eplerenone, thereby prolonging its effect on the body.
Angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARB) jointly treat high blood pressure, heart disease, or particular kidney conditions. They may interact with eptus 25 tablet as these drugs may raise the possibility of high potassium levels in your blood.
Lithium is usually given to manage manic depressive disorder or bipolar disorder. Using lithium together with diuretics and ACE inhibitors has been shown to increase lithium levels in the blood, which may lead to side effects such as loss of appetite; visual impairment; tiredness; muscle weakness; muscle twitches.
Immune-suppressing drugs like Cyclosporin treats skin conditions such as psoriasis or eczema and curb rejection after organ transplantation. These drugs can lead to kidney problems.
Non-steroidal anti-inflammatory drugs (NSAIDs) - pain killers such as ibuprofen, used to relieve pain, stiffness and inflammation. These drugs may lead to kidney problems.
An anti-clotting drug like Warfarin: When taking warfarin, caution is advised since high blood levels of warfarin may alter how Eplerenone affects the body.
Anti-seizure drugs such as carbamazepine, phenytoin, and phenobarbital are used, among others, to treat epilepsy and may increase the breakdown of Eplerenone and thus decrease its effect.

It is essential to inform your doctor of any vitamins, supplements, or herbal products you are taking, as they may interact with Eptus 25 tablet and affect its efficacy or increase the risk of side effects.

Drug-Food Interactions

There are no known drug-food interactions associated with Eptus 25 tablet. However, it is recommended to avoid consuming excessive alcohol as it may increase the risk of side effects associated with the medication.

Drug-Disease Interactions

The Eptus 25 tablet may interact with specific diseases and health conditions, affecting its efficacy or increasing the risk of adverse effects.

Low blood pressure: Eptus tablet may cause a decrease in blood pressure, which can be more significant in patients with already low blood pressure. Therefore, it should be used cautiously in patients with hypotension or antihypertensive medications.
Coronary heart disease: Eptus tablet should be used cautiously in patients with coronary heart disease or a history of myocardial infarction, as it may increase the risk of cardiovascular events.
Liver or kidney disease: Eptus tablet is metabolised in the liver and excreted by the kidneys, and its elimination may be impaired in patients with liver or kidney disease. Therefore, dosage adjustments may be necessary for these patients, and close monitoring of kidney function is recommended.
Heart failure: Eptus tablet is indicated for treating heart failure with reduced ejection fraction. However, caution should be exercised in patients with severe heart failure, as it may increase the risk of hyperkalemia.
High serum potassium: Eptus tablet may cause an increase in serum potassium levels, especially in patients with chronic kidney disease or diabetes mellitus. Therefore, serum potassium levels should be monitored regularly in these patients.
Diabetes mellitus type 2: Eptus tablet may affect glucose metabolism, and caution should be exercised in patients with diabetes mellitus type 2. Blood glucose levels should be monitored regularly in these patients.
Patients with nil urine output (anuria): The kidneys primarily eliminate Eptus tablet, and its elimination may be impaired in patients with anuria. Therefore, it is contraindicated in these patients.

Daily Dose

The recommended daily dose of Eptus 25 tablet is one tablet once daily, with or without a meal, as directed by your doctor. The dosage may change based on individual factors such as the severity of the condition and response to treatment. It is essential to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you or someone else takes an excessive amount of Eptus 25 tablet by accident, it is essential to take immediate medical attention from your doctor or nearby hospital. Symptoms of an overdose include low blood pressure, dizziness, blurred vision, weakness, muscle cramps, diarrhoea, nausea or a headache.

Missed Dose

If you forgot to take an Eptus 25, take it as soon as you remember or As instructed by your healthcare provider. If the time for the next dosage is close, skipping the missed one is recommended now and resuming your regular dosage pattern. Never increase your dosage without consulting your doctor.

Store Eptus 25 tablets at room temperature (15-25ºC).
Please protect it from light and moisture.
Keep Eptus tablet away from children.
Do not use Eptus tablet after the expiry date has passed.

Besides taking medication, several diet and lifestyle tips can help manage hypertension and support the effectiveness of Eptus tablet.

The Dietary Approaches to Stop Hypertension, also known as DASH, is an excellent model of a healthy diet for people with hypertension. This diet is rich in Antioxidant-rich fruits and vegetables such as Blueberries, cherries, tomatoes, squash, bell peppers, Asparagus, beets, green beans, grapes, onion, leafy greens, pineapple, leeks, pumpkin, and garlic that help you get rid of excess water from your body.
Avoid high-sodium foods such as processed meats and snacks.
Choose healthy cooking oils like soybean, olive, canola, and coconut.
You should avoid food with refined flour, such as white bread and spaghetti.
Reduce or eliminate the consumption of trans fatty acids from commercially baked items such as cookies, cakes, crackers, French fries, doughnuts, and processed foods.
Avoid the consumption of too much salt or salty food.
Maintain your weight under control with a BMI of 19.5-24.9.
Chronic stress can increase blood pressure. Regular exercise and walking improves blood flow and is an excellent stress management method.
Keeps your legs or the swollen area at a height on a chair or pillow.
Refrain from standing or sitting for long periods.
Smoking can narrow blood vessels and increase blood pressure. Quitting smoking can improve blood pressure and overall cardiovascular health.
Avoid drinking excessive amounts of alcohol as it can increase blood pressure and interfere with the effectiveness of Eptus tablet.

Frequent serum potassium and creatinine tracking are required during Eptus 25 Tablet 15 treatment.
Observe your blood pressure daily; contact your doctor immediately if excessive fluctuation occurs.
Track your blood sugar levels daily, and contact your doctor immediately if excessive fluctuation occurs.
The amount of time taken by Eptus 25 mg Tablet to demonstrate its action is one to two hours, and it remains for one to two days in your body.
It may raise the potassium level in your blood. Avoid potassium supplements as well as potassium-rich meals like bananas and broccoli.

Fact Box

Drug Category	Potassium-sparing Diuretics
Therapeutic Category	Antihypertensive
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Hypertension (high blood pressure), Edema

What is Eptus 25 used for?

Eptus Tablet is used to treat conditions related to the gastrointestinal system, such as acid reflux, heartburn, and indigestion. It helps reduce stomach acid and provides relief from symptoms like burning sensations and discomfort.

Is Eptus 25 a blood thinner?

No, Eptus tablet is not a blood thinner. It is a potassium-sparing diuretic that prevents the action of aldosterone, a hormone responsible for maintaining the water and salt balance.

Does Eptus tablet increase creatinine?

There is no clear evidence to suggest that Eptus tablet increases creatinine levels. However, if you are concerned about your creatinine levels, it is recommended to consult with a healthcare professional.

What is the generic name for Eptus 25 mg tablet?

The generic name for Eptus 25 mg tablet is eplerenone.

Is Eptus 25 tablet bad for kidneys?

Eptus 25 mg Tablet is eliminated through urine, and pre-existing kidney problems can cause this medicine to accumulate in your kidney, causing severe damage. As a result, it is not advised in such circumstances.

What is the composition of Eptus 25 mg tablet?

Eptus 25 tablet contains Eplerenone, a medication associated with a class of drugs known as selective aldosterone-blocking agents. These drugs prevent the action of aldosterone, which regulates blood pressure and heart function.

Does Eptus 25 tablet increase urination?

Yes, Eptus 25 tablet is a diuretic (water pill), so it will make you urinate more often. It makes your body remove excess salt and water, which helps lower your blood pressure.

What does Eptus 25 tablet do for the heart?

Eptus 25 tablet keeps potassium levels in check, removes extra water, and prevents hypertension (high blood pressure) brought on by oedema (fluid retention).

Can Eptus 25 tablet raise blood pressure?

No, Eptus 25 tablet does not raise blood pressure. Eptus 25 mg Tablet is used to treat high blood pressure when taken alone or in combination with other medications.

Is Eptus 25 tablet a steroid?

No, Eptus 25 tablet is not a steroid. It belongs to a class of medicines called diuretics (water pills) that helps to eliminate excess water from the body and treat hypertension.

Can Eptus 25 tablet cause liver damage?

It is also essential to let your healthcare provider know if you have a history of liver disease or are taking other medications that can affect the liver. These factors may increase your risk of liver damage from Eptus 25 tablet.

Last Updated On 24 Mar. 2025 | 12:08PM (IST)

Certified Content

Written by

Dr. Sachin Singh

Medical Team Lead | 6 years

MBBS

Reviewed by

Dr. Mandeep Chadha

Lead Medical Content Reviewer | 11 years

MBBS, DNB (OBGY)

Check out Editorial Policy

Manufacturer details

Glenmark House, HDO-Corporate Building, Wing-A, B.D. Sawant Marg, Chakala Off. Western Express Highway, Andheri (East), Mumbai, Maharashtra, 400099 India

Country of origin: INDIA

References

KD Tripathi. Diuretics. Essentials of Medical Pharmacology. Seventh Edition,2013. Page-589.
Alan J Zillich 1, Barry L Carter. Eplerenone--a novel selective aldosterone blocker.NIH: National Library of Medicine, National center of biotechnology Information Pubmed.gov.Oct 2002. [Accessed 17 Nov 2020] https://pubmed.ncbi.nlm.nih.gov/12243608/
Accord Healthcare Limited; Electronic Medicines Compendium (EMC); [Revised on Aug 2017] [Accessed 17 Nov 2020] https://www.medicines.org.uk/emc/files/pil.7055.pdf

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