Valsac 24/26 MG Tablet 28

Natco Pharma Ltd

Pack of 28 Units

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Composition

Sacubitril (24 Mg) + Valsartan (26 Mg)

Valsac 24/26 MG Tablet 28 is used to manage certain types of heart failure in adults, especially those with reduced ejection fraction despite optimal treatment. It helps improve heart function and reduce symptoms associated with heart failure.

This medication is particularly effective for adults with symptomatic heart failure who have reduced ejection fraction, a situation where the heart isn't pumping blood as efficiently as it should. Despite optimal treatment with other heart failure medications, if symptoms persist, Valsac 24/26 MG Tablet 28 can help reduce risks associated with cardiovascular death and hospitalisation due to heart failure.

For best results, it's essential that you take this medicine as directed by your doctor. Before starting this tablet, make sure you inform your doctor of any pre-existing conditions or ongoing medications. If you experience any side effects while on this medication, immediately notify your doctor. It's also crucial that you continue taking the medicine for the duration prescribed by your doctor for optimal results.

Valsac 24/26 MG Tablet 28 is generally used for the following health conditions:

Management of symptomatic heart failure in adults.
Improvement of reduced ejection fraction, a condition where the heart doesn't pump blood efficiently.
Reducing the chances of cardiovascular death in heart failure patients.
Lowering the risk of hospitalisation due to heart failure.

Swallow the tablet whole with a glass of water. Avoid crushing or chewing it.
You can take it with or without food, as per your comfort.
Do not increase or decrease the dose without consulting your doctor.

Valsac 24/26 MG Tablet 28 is taken orally.

Valsac 24/26 MG Tablet 28 may have the following common side effects:

Low blood pressure (hypotension)
High potassium levels (hyperkalaemia): This means there's too much potassium in your blood.
Kidney dysfunction: This could mean your kidneys aren’t working as well as they should be.
Cough
Dizziness
Diarrhoea
Headache
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Valsac 24/26 MG Tablet 28. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips for managing common side effects:

Dizziness: Try taking Valsac 24/26 MG Tablet 28 at night, this might help manage dizziness during your daily activities.
Diarrhoea: Consider taking this medicine with food to lessen this effect.

Valsac 24/26 MG Tablet 28 contains two active components that work together in complementary ways:

Sacubitril (24 mg): This component inhibits an enzyme called neprilysin in your body. Neprilysin is responsible for breaking down certain beneficial peptides that promote blood vessel dilation. By blocking neprilysin, sacubitril increases the levels of these peptides, leading to vasodilation and improved kidney function.
Valsartan (26 mg): Valsartan blocks a specific receptor in your body known as the angiotensin II receptor type-1 (AT1). By inhibiting this receptor, valsartan prevents the narrowing of blood vessels and the secretion of a hormone called aldosterone, reducing sodium and water retention in your body.

Pregnancy

Valsac 24/26 MG Tablet 28 is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Valsac 24/26 MG Tablet 28 is not recommended for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

There's no known interaction between Valsac 24/26 MG Tablet 28 and alcohol, but it's always wise to consult your doctor before consuming alcohol while taking this medicine.

Liver

Caution is advised while taking Valsac 24/26 MG Tablet 28 in case of mild to moderate liver impairment. This medicine isn't recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting Valsac 24/26 MG Tablet 28.

Kidney

Caution is advised before using Valsac 24/26 MG Tablet 28 if you have a history of any kidney problems. It's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

As Valsac 24/26 MG Tablet 28 may cause dizziness, it's advisable to avoid driving or operating heavy machinery until you know how the medicine affects you.

Allergy

If you're allergic to sacubitril or valsartan, do not take Valsac 24/26 MG Tablet 28. Consult your doctor if you've had an allergic reaction to similar medicines in the past.

Children

Valsac 24/26 MG Tablet 28 is not recommended for use in children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Valsac 24/26 MG Tablet 28 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age.

Drug-Drug Interactions

Valsac 24/26 MG Tablet 28 interacts with the following medicines:

ACE Inhibitors: Medicines such as enalapril or lisinopril may interact with Valsac 24/26 MG Tablet 28, potentially leading to increased risk of angioedema and low blood pressure.
ARBs: Other angiotensin receptor blockers like losartan can interact with Valsac 24/26 MG Tablet 28, increasing the risk of hypotension.
Potassium-Sparing Diuretics: Diuretics like spironolactone or amiloride, when taken with Valsac 24/26 MG Tablet 28, might increase the levels of potassium in your blood.
NSAIDs: Non-Steroidal Anti-Inflammatory Drugs including ibuprofen or naproxen could decrease the blood pressure-lowering effect of Valsac 24/26 MG Tablet 28 and increase the risk of kidney problems.

Drug-Food Interactions

There are no clinically significant food interactions identified with Valsac 24/26 MG Tablet 28. It can be taken with or without food.

Drug-Disease Interactions

Valsac 24/26 MG Tablet 28 interacts with the following diseases:

Liver Disease: Caution is advised for patients with moderate liver impairment as it may affect how Valsac 24/26 MG Tablet 28 works in your body.
Renal Impairment: Patients with severe kidney disease should take care as Valsac 24/26 MG Tablet 28 could exacerbate their condition.
Hypotension: Individuals suffering from low blood pressure might experience further decreases in blood pressure levels when taking Valsac 24/26 MG Tablet 28.

Daily Dose

Take your daily recommended dose of Valsac 24/26 MG Tablet 28 as your doctor prescribes. The dosage can vary depending on factors such as your condition's severity and your treatment response. It's crucial to stick to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you accidentally take more than the prescribed dose of Valsac 24/26 MG Tablet 28, you might experience symptoms like low blood pressure, high potassium levels, and kidney dysfunction. If these symptoms persist or worsen, inform your doctor.

Missed Dose

If you forget to take your Valsac 24/26 MG Tablet 28 at the scheduled time, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one and continue with your regular dosage schedule. Never alter your dosage without consulting your doctor.

Keep your Valsac 24/26 MG Tablet 28 in its original packaging to protect it from moisture.
Store it at room temperature below 30°C.
Ensure it is kept out of the reach and sight of children.
It's crucial to use this medicine before the expiry date printed on the pack.

Since Valsac 24/26 MG Tablet 28 is used to manage heart failure, it's important that you limit your salt intake. This can help reduce fluid build-up and pressure on your heart.
Regular light exercise, such as walking or cycling, may also help improve your cardiovascular health. However, do ensure you consult with your doctor about the right level of physical activity for you.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Heart Failure, Reduced Ejection Fraction
Drug Category	Neprilysin Inhibitor, Angiotensin Receptor Blocker
Therapeutic Category	Heart Failure Medication

What is Valsac 24/26 MG Tablet 28 used for?

Valsac 24/26 MG Tablet 28 is used to manage certain types of heart failure in adults, specifically those with reduced ejection fraction despite optimal treatment.

How does Valsac 24/26 MG Tablet 28 work in the body?

Valsac 24/26 MG Tablet 28 contains sacubitril and valsartan which relaxes blood vessels, reduces strain on the heart, and helps it pump blood more efficiently by reducing fluid retention and cardiac stress.

Can I take Valsac 24/26 MG Tablet 28 with food?

Yes, Valsac 24/26 MG Tablet 28 tablets can be taken with or without food. They should be swallowed whole with a glass of water.

What are the common side effects of Valsac 24/26 MG Tablet 28?

Common side effects may include low blood pressure, high potassium levels, kidney dysfunction, cough, dizziness, diarrhoea, headache, and fatigue.

Can I take Valsac 24/26 MG Tablet 28 if I am pregnant or breastfeeding?

Use in pregnancy or breastfeeding is not recommended. Please consult your doctor for advice.

Are there any medicines that interact with Valsac 24/26 MG Tablet 28?

Yes, certain medicines like ACE inhibitors, ARBs, aliskiren, potassium supplements or substitutes, NSAIDs and lithium may interact with Valsac 24/26 MG Tablet 28. Please inform your doctor about all medications you are currently taking.

How should I store my Valsac 24/26 MG Tablet 28?

Store your Valsac 24/26 MG Tablet 28 tablets at room temperature below 30°C. Protect them from moisture and keep them in their original package until use.

Last Updated On 13 May. 2025 | 11:18AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Natco House Road No.2, Banjara Hills Hyderabad-500 034, India

Country of origin: INDIA

Expiry on or after: October 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

ENTRESTO® (sacubitril and valsartan) tablets. (N.d.). Fda.Gov. Retrieved August 28, 2024, from
https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto tablets.(N.d.). Europa.Eu. Retrieved August 28, 2024, from https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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