The mechanism of Candid B cream involves the individual activities of its two active ingredients, Clotrimazole and Beclometasone Dipropionate. Clotrimazole exerts its action primarily by damaging the permeability barrier in the fungal membrane. Clotrimazole inhibits the biosynthesis of ergosterol, an essential component of the fungal cell membrane that maintains its structure. When ergosterol synthesis becomes inhibited, the fungi cell can no longer perform its normal function. The disruption of the fungal cell membrane leads to its death.
When Candid B cream is applied topically, beclometasone dipropionate penetrates the skin and binds to cytoplasmic glucocorticoid receptors, a protein within the skin cells. It activates the glucocorticoid receptors protein, suppressing the growth of pro-inflammatory genes and stimulating the anti-inflammatory genes. It reduces the production of inflammatory cytokines, and chemokines, the proteins that contribute to skin inflammation.
Furthermore, beclometasone dipropionate also inhibits the migration of immune cells, such as neutrophils and macrophages, to the site of inflammation. It reduces the number of inflammatory cells at the site of infection and subsequently reduces skin inflammation.
The anti-inflammatory and immunosuppressive properties of beclometasone dipropionate help to reduce skin inflammation and symptoms associated with skin infections.