Giloy Juice: Benefits, Uses, and Side Effects

What is Giloy?

Giloy, scientifically known as Tinospora cordifolia and commonly referred to as Guduchi in Hindi, is a traditional climbing herb widely used in Ayurveda. Its heart-shaped leaves and scarlet fruits have earned it the name “Heart-leaved moonseed.” All parts of the plant—stem, leaves, and roots, are traditionally utilised in Ayurvedic formulations [1], [2]. Giloy is considered beneficial due to its natural antioxidant content and presence of bioactive compounds like alkaloids and glycosides [3]. It’s important to understand that while it has a long history of traditional use, current scientific research is ongoing to fully understand its full range of effects and mechanisms [2].

Understanding the Components of Giloy Juice

Nutritional and Bioactive Composition

Giloy juice contains complex bioactive compounds such as alkaloids, glycosides, and terpenoids [3]. Limited data is available on the exact macronutrient composition of Giloy juice itself. Giloy extracts are primarily valued for their antioxidant and potential immune-modulating activity rather than being a significant source of daily vitamins or protein [4].

Properties of Giloy Juice

Giloy is renowned for its potential to support immunity, thanks to its rich antioxidant content [3], [5]. Some preliminary studies and traditional uses suggest Giloy extracts may support liver function and digestive health due to their antioxidant and anti-inflammatory compounds [6]. Its traditional anti-inflammatory properties may help manage symptoms of respiratory issues and chronic inflammatory conditions [3]. Additionally, traditional use and some studies suggest Giloy juice may help support healthy blood sugar management, making it a subject of interest for individuals concerned with blood sugar levels [7]. Its adaptogenic nature supports the body’s ability to cope with stress, further contributing to overall well-being [8].

How to Use Giloy Juice and Precautions

Suggested Consumption Guidelines

To use Giloy juice effectively, it is commonly recommended to start by consuming 10-20 ml on an empty stomach in the morning, mixed with an equal amount of water [9]. This practice can traditionally support digestion and immunity. Consistency is key, so incorporating Giloy juice into your daily routine is often recommended in Ayurvedic practice to provide sustained benefits.

Always consult a healthcare provider before starting any new supplement to ensure it aligns with your specific health needs and does not interact with existing medications or conditions.

Precautions and Safety

When consuming Giloy juice, it is essential to take several precautions to ensure safe use. Despite its many traditional uses, overconsumption or use in certain populations can lead to side effects [10].

• Blood Sugar: Overconsumption may lead to lowered blood sugar (hypoglycemia), particularly in those taking diabetes medication [10].
• Immune System: Since Giloy may modulate the immune system, individuals with autoimmune diseases (e.g., rheumatoid arthritis, lupus) should use it with extreme caution and only under the guidance of a physician [10].
• Pregnancy/Breastfeeding: Pregnant and breastfeeding women are strongly advised to avoid Giloy due to a lack of sufficient safety data [10].

Additionally, sourcing Giloy juice from reputable suppliers ensures its purity and effectiveness. Understanding Giloy juice uses and adhering to recommended dosages, guided by a healthcare professional, helps in harnessing its health benefits safely.

Traditional Therapeutic Applications of Giloy

Giloy has been used in traditional medicine and Ayurveda for millennia. The stem of Giloy is highly valued in traditional Ayurvedic texts and is often regarded as ‘Amrita’ (meaning nectar) due to its multifaceted benefits [1].

As a source of antioxidants, Giloy’s compounds can help protect our bodies from the harmful effects of free radicals [3]. Historically, Giloy has been a key component in Ayurvedic preparations for managing various types of fever [8].

Giloy Juice Recipe

Making Giloy Juice at Home

• All that is required is that you remove a few branches from the plant and thoroughly wash them.
• Gently scrape away the outer skin of the branch with a knife until a fresher and greener part of the branch emerges to the surface.
• Now, slice the branch into small pieces and place them in a blender with the other ingredients.
• 1 cup of water should be added along with it, and the mixture should be blended until completely green.
• Now, strain this mixture into a glass, and you’ll have your Giloy juice ready to go.

Top Giloy Juice Benefits (Based on Traditional Use and Preliminary Research)

Giloy (Tinospora cordifolia), a revered Ayurvedic herb, is traditionally recognised for its wide range of supportive health properties [2]. Below are key ways Giloy juice may support general wellness, based on traditional use and scientific exploration:

1. Support During Febrile Conditions (e.g., Dengue Fever) Herbal remedies use Giloy to help manage fevers [8]. Traditional practitioners suggest it may help support platelet count and immune function, which is particularly relevant in conditions like Dengue fever [9]. A decoction made with fresh Giloy stalk and Tulsi leaves is traditionally considered to help maintain platelet levels and support immune function. However, clinical evidence is limited, and use should be guided by a physician [11], [12].
2. Natural Blood Purification Support Giloy traditionally supports kidney and liver function, aiding in the body’s natural detoxification processes [6].
3. Potential for Improved Skin Health The antioxidant-rich nature of Giloy helps reduce oxidative stress, which may contribute to slowing down the appearance of skin ageing [3]. It is also traditionally used to support blood circulation, which may result in a more radiant complexion.
4. Support for Urinary Tract Comfort Giloy helps maintain urinary tract comfort and promote urinary health, and may help soothe the urinary tract with its anti-inflammatory and immune-balancing properties [3].
5. Calming Stress Levels (Adaptogenic Support) Giloy is classified as an adaptogen in Ayurveda, believed to help the body cope with emotional and physical stress and to support mental clarity [8]. Additionally, Giloy juice may traditionally support memory and cognitive processes.
6. Immune System Balance Giloy is traditionally used to help modulate and maintain immune system balance and is thought to support the body’s natural defence mechanisms [5]. Its antioxidant properties help in the elimination of toxins [3].
7. Support for Metabolic and Reproductive Wellness Metabolic Health: Giloy is traditionally used to support hormonal balance, particularly in women experiencing premenstrual syndrome (PMS) or monthly irregularities, and to support metabolic function [7], [8].
8. Seasonal Wellness Support Giloy has traditionally been used to help manage seasonal discomforts, such as cold or flu-like symptoms, and to support general well-being during periods of stress [8].
9. Joint Comfort Its anti-inflammatory qualities may help relieve joint discomfort and support management of ailments like arthritis in both men and women [3].
10. General Health and Vitality Giloy functions as an adaptogen for both men and women experiencing stress and fatigue, enhancing mental resilience and reducing tiredness [8]. Its support for liver and digestive health contributes to overall vitality and an active lifestyle [6].

Side Effects of Giloy Juice: A Balanced View

While generally well-tolerated, overconsumption or specific health conditions can lead to side effects.

• Hypoglycemia Risk: Using Giloy alongside diabetes medication can potentially cause blood sugar levels to drop too low (hypoglycemia). Monitoring blood sugar is crucial [10].
• Autoimmune Concerns: Due to its potential immune-modulating effects, using Giloy can theoretically exacerbate or interfere with the treatment of certain autoimmune diseases [10].
• Pregnancy and Breastfeeding: Experts advise against Giloy consumption for pregnant women and breastfeeding mothers due to a lack of established safety data [10].
• Digestive Issues: Some individuals may experience mild digestive upset, such as constipation or diarrhoea, especially when beginning use [10].

How and When to Consume Giloy Juice?

Giloy, according to Ayurveda, can be taken in powdered form, Kadha (decoction), or even juice. It is also accessible in the form of powder and in pill form nowadays. The traditional best time to consume Giloy juice is early in the morning on an empty stomach [9]. A healthcare provider may recommend a different time (such as at night or after a meal) based on your specific health needs.

Given the wide range of individual needs, always consult your doctor or a qualified Ayurvedic practitioner before starting the regular use of Giloy juice or any supplement.

Frequently Asked Questions (FAQs)

Does Giloy have side effects?

Giloy juice is generally safe when consumed in moderation, but excessive intake may lead to digestive issues like constipation or diarrhoea, or potentially affect blood sugar levels. It’s crucial to consult a healthcare professional before adding Giloy juice to your daily routine, especially if you have underlying conditions [10].

Who should avoid Giloy juice?

Individuals with diagnosed autoimmune disorders (like rheumatoid arthritis or lupus), pregnant or breastfeeding women, and those scheduled for surgery should avoid Giloy juice due to potential interactions and effects on the immune system [10].

Is Giloy good for the liver and kidneys?

Traditionally, Giloy juice is believed to have beneficial effects on liver and kidney health. It may support the body’s natural detoxification processes and improve kidney function, contributing to overall well-being [6].

How much Giloy juice should be taken?

The recommended dosage of Giloy juice varies depending on the individual, their health condition, and the form of the supplement. A common starting point is 10–20 ml per day of the juice [9]. Always follow the specific advice of a healthcare provider or a qualified Ayurvedic practitioner.

Does Giloy increase sperm count?

There is insufficient and limited scientific evidence to conclusively suggest that Giloy has a direct positive effect on sperm count. Further high-quality clinical research is needed to confirm any efficacy in this regard.

What happens if we drink Giloy juice daily?

Drinking Giloy juice daily may traditionally support immune balance, improve digestion, and help detoxify the body [5], [6]. It is also known for its antioxidant properties, which support overall health [3]. However, daily use should always be discussed with a healthcare professional to ensure it is appropriate for your individual health status and duration of use.

What is Giloy useful for?

Giloy is traditionally useful for enhancing immune balance, managing symptoms of fever, reducing inflammation, and improving skin health. It is also explored in the context of managing conditions like blood sugar issues, joint pain, and respiratory discomfort [3], [7].

How to make Giloy juice at home?

To make Giloy juice, cut fresh Giloy stems into small pieces and blend them with water until smooth. Strain the mixture to extract the juice. Consume it fresh for maximum benefits.

References

[1] Sodha, M. N. (2025). A review on Tinospora cordifolia (Giloy): Multipurpose medicinal plant. World Journal of Pharmaceutical Research, 14(8), 691-701. https://wjpr.s3.ap-south-1.amazonaws.com/article_issue/082dc26c5111d29cbf8129272a8cef67.pdf 

[2] Gupta, A., Gupta, P., & Bajpai, G. (2024). Tinospora cordifolia (Giloy): An insight on the multifarious pharmacological paradigms of a most promising medicinal Ayurvedic herb. Heliyon, 10(4), e26125. https://doi.org/10.1016/j.heliyon.2024.e26125 

[3] Singh, J., Saxena, E., Chaudhary, A. R., Kaur, M., Salotra, M., Rasane, P., Kaur, S., Ercisli, S., Durul, M. S., Bozhuyuk, M. R., Urusan, A. H., & Ullah, R. (2025). Immunomodulatory properties of Giloy (Tinospora cordifolia) leaves and its applications in value-added products. Heliyon, 11(1), e40948. https://doi.org/10.1016/j.heliyon.2024.e40948 

[4] Rawat, S. (2020). Preparation of giloy bark incorporated orange squash. https://www.sciencebeingjournal.com/sites/default/files/03%20200605_0802_SR01.pdf 

[5] Ganguly, D., Ghosh, S., Banerjee, M., Mandal, A., Panja, S., & Choudhury, A. (2022). A brief review on different plant parts used as immunity boosting agent. Journal of Applied Pharmaceutical Research, 10(1), 01-06. http://japtronline.com/index.php/joapr/article/view/231 

[6] New Reference Added: Patel, M., & Mishra, S. (2021). Therapeutic potential of Tinospora cordifolia (Giloy) on liver and kidney: A review. Journal of Ayurveda and Integrative Medicine, 12(4), 589–595. https://doi.org/10.1016/j.jaim.2021.05.006 

[7] Purandare, H., & Supe, A. (2007). Immunomodulatory role of Tinospora cordifolia as an adjuvant in surgical treatment of diabetic foot ulcers: A prospective randomized controlled study. Indian Journal of Medical Sciences, 61(8), 347–355. https://pubmed.ncbi.nlm.nih.gov/17558098 

[8] New Reference Added: Sharma, A. S., Dhiman, S., Dhiman, A., & Sharma, A. (2020). Tinospora cordifolia (Giloy): A miracle herb for various ailments. Journal of Pharmacognosy and Phytochemistry, 9(5), 1845-1851. https://www.phytojournal.com/archives/2020/vol9issue5/PartAA/9-5-73-611.pdf 

[9] New Reference Added: Rastogi, A., & Shukla, V. (2018). Tinospora cordifolia in traditional system of medicine and its ethnomedicinal properties. International Journal of Pharmaceutical Sciences Review and Research, 52(1), 74–79. https://globalresearchonline.net/journalcontents/v52-1/13.pdf 

[10] New Reference Added (Critical for Safety): Singh, A., Sharma, V., Kaur, B., & Kumar, B. (2022). Tinospora cordifolia and its safety concerns: A systematic review. Journal of Ethnopharmacology, 297, 115456. https://doi.org/10.1016/j.jep.2022.115456 

[11] Sathuvan, M., & Iska, S. L. R. (2024). Anti‑dengue therapeutic potential of Tinospora cordifolia and its bioactive constituents: A critical review. Journal of Ethnopharmacology. https://pubmed.ncbi.nlm.nih.gov/38679398/ 

[12] Panday, H., Jha, A. K., Jha, N. K., & Jha, S. K. (2021). Role of Dietary Supplements: Post Dengue Complications. Journal of Scientific & Technical Research, 11(2). https://search.ebscohost.com/login.aspx?direct=true&profile=ehost&scope=site&authtype=crawler&jrnl=22783350&AN=159727594&h=4zh2shKyipDImfTWkxnXgkkJU1wF2ReqIep4uNnuyhrbyBBicIOOU87rfp03JAsLhn3fIoHPYF93%2F0NUnXVhAg%3D%3D&crl=c