Neptaz 100 Tablet 14

Mankind Pharmaceuticals Ltd.

Strip of 14 Units

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MRP ~~₹554.24~~

₹443.39

₹39.59/Units

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*MRP inclusive of all taxes

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Prescription required for this medicine

Store Below 30° C

Composition

Sacubitril (49 Mg) + Valsartan (51 Mg)

Neptaz 100 Tablet is a combination cardiovascular medicine used to treat chronic heart failure in adults with reduced ejection fraction. It helps improve the heart's pumping efficiency and reduces the risk of hospitalisation and cardiovascular death.

It contains sacubitril and valsartan, an angiotensin receptor-neprilysin inhibitor (ARNI). Take it with or without food as prescribed by your doctor. Continue taking it regularly even if your symptoms improve. Do not stop taking it without consulting your doctor.

Follow a low-sodium (low-salt) diet, monitor your daily body weight, engage in light activity as advised, and restrict fluid intake if recommended by your cardiologist.

Before starting this medicine, tell your doctor if you have severe kidney or liver disease, diabetes, or a history of swelling (angioedema). Do not take this medicine if you are taking an ACE inhibitor; a 36-hour wash-out period is required between these medicines.

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Neptaz 100 Tablet is used in adults to treat chronic heart failure and protect the cardiovascular system.

Uses of Neptaz 100 Tablet are:

Chronic Heart Failure: Treats symptomatic chronic heart failure in adults with reduced heart pumping ability.
Reduction of Hospitalisation Risk: Decreases the chance of hospital admissions caused by heart failure flare-ups.
Cardiovascular Risk Reduction: Helps lower the risk of heart-related complications and cardiovascular death.

To use Neptaz 100mg Tablet correctly, follow these instructions:

Swallow the tablet whole with a glass of water. Do not crush or chew it.
Always follow your doctor's advice regarding how and when to take this medicine.
Do not alter the dose without consulting your doctor.
It's essential not to stop taking this medicine without first consulting your doctor.

Neptaz 100mg Tablet is taken orally.

Neptaz 100 Tablet may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Neptaz 100 Tablet:

Cardiovascular: Low blood pressure (hypotension), which may cause lightheadedness or dizziness.
Metabolic: Increased potassium levels in the blood (hyperkalaemia).
Respiratory: Mild dry cough.
Digestive: Feeling sick (nausea).
General: Unusual tiredness (fatigue).
Kidney: Slight changes in kidney function test results.

If side effects do not improve or become serious, speak to your doctor right away.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Neptaz 100mg Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Dizziness: Consider taking Neptaz 100mg Tablet at bedtime to lessen this effect.
Nausea: Try taking Neptaz 100mg Tablet with meals to reduce nausea.

Neptaz 100mg Tablet consists of two active ingredients:

Sacubitril (49 mg): This component works by inhibiting an enzyme known as neprilysin. This enzyme is responsible for breaking down natriuretic peptides in the body. By inhibiting neprilysin, sacubitril helps increase the levels of these peptides that aid in relaxing blood vessels, eliminating excess sodium and water from the body, and reducing strain on the heart.
Valsartan (51 mg): This ingredient functions by blocking the action of angiotensin II, a hormone known to cause blood vessels to narrow thereby increasing blood pressure. By blocking angiotensin II receptors, valsartan aids in relaxing and widening blood vessels which results in reducing workload on the heart.

Together, these actions contribute towards improving heart function, reducing symptoms of heart failure, and decreasing risk of hospitalisation and cardiovascular death.

Pregnancy

Neptaz 100mg Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, please discuss this with your doctor before starting this medicine.

Breastfeeding

Neptaz 100mg Tablet is not recommended for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while taking Neptaz 100mg Tablet if you consume alcohol. Alcohol may alter the effects of this medicine. Discuss this with your doctor for more information.

Liver

If you have liver health issues, caution is advised while taking Neptaz 100mg Tablet. Your doctor will guide you based on your health status.

Kidney

Caution is advised before taking Neptaz 100mg Tablet if you have a history of kidney problems. Consult your doctor before starting this medication.

Use In Driving And Operating Machinery

Neptaz 100mg Tablet may cause dizziness, affecting your ability to drive or operate machinery. Do not drive or operate machinery until you know how this medicine affects you.

Allergy

If you are allergic to sacubitril or valsartan, do not take Neptaz 100mg Tablet. Always inform your doctor about any allergies before starting a new medication.

Children

Neptaz 100mg Tablet is not recommended for children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Neptaz 100mg Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Neptaz 100mg Tablet interacts with the following medicines:

ACE inhibitors: Medicines like enalapril and lisinopril may interact with Neptaz 100mg Tablet, potentially increasing the risk of high potassium levels in your blood (hyperkalaemia).
Potassium-sparing diuretics: When taken alongside Neptaz 100mg Tablet, diuretics like spironolactone and triamterene may raise the levels of potassium in your blood.
Potassium supplements: These supplements can further increase potassium levels when used concurrently with Neptaz 100mg Tablet.
Nonsteroidal anti-inflammatory drugs (NSAIDs): NSAIDs such as ibuprofen can reduce the blood pressure-lowering effects of Neptaz 100mg Tablet.

Drug-Food Interactions

There are no specific food items known to interact with Neptaz 100mg Tablet.

Drug-Disease Interactions

Neptaz 100mg Tablet interacts with the following diseases:

Liver disease: If you have liver disease, you may need to take a lower dose of Neptaz 100mg Tablet as it may worsen your condition.
Kidney disease: Patients with kidney disease should use caution while taking Neptaz 100mg Tablet as it could exacerbate their condition.
Diabetes: Diabetic patients should monitor their blood sugar closely while on this medication as it might impact blood sugar control.
Low Blood Pressure: People suffering from low blood pressure should be cautious while taking this medicine as it could further lower blood pressure.

Daily Dose

The Neptaz 100mg Tablet should be taken as instructed by your doctor. The dosage may vary depending on individual factors like the severity of your condition and how you respond to the medication. Never change the prescribed dosage without consulting your doctor.

Over Dose

Overdosing on Neptaz 100mg Tablet might lead to symptoms such as dizziness, nausea, or fatigue. If you experience these symptoms after taking a higher dose than prescribed, inform your doctor.

Missed Dose

If you forget to take the Neptaz 100mg Tablet at the scheduled time, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Always consult your doctor before making any changes to your dosage.

Store Neptaz 100mg Tablet at room temperature, ideally between 20-25 degrees Celsius.
Keep the medicine away from light and moisture to maintain its efficacy.
Always keep this medication out of reach of children for safety reasons.
Make sure to use the tablet before its expiry date for the best results.

To enhance the effectiveness of Neptaz 100mg Tablet in managing heart failure, it's important to have a diet low in salt. Excessive sodium can increase blood pressure and worsen heart conditions.
Regular physical activity, as recommended by your doctor, can help strengthen your heart and improve blood circulation, complementing the action of Neptaz 100mg Tablet.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Chronic Heart Failure, Reduced Ejection Fraction
Drug Category	Neprilysin Inhibitor, Angiotensin II Receptor Blocker
Therapeutic Category	Heart Failure Management

What is Neptaz 100mg Tablet used for?

Neptaz 100mg Tablet is prescribed to manage adult heart failure, specifically cases with reduced ejection fraction, to lessen the risk of cardiovascular death and hospitalization.

How does Neptaz 100mg Tablet work?

Neptaz 100mg Tablet contains sacubitril and valsartan. Sacubitril increases peptides that relax blood vessels and reduce heart strain, while valsartan widens blood vessels, reducing heart workload.

Can I take Neptaz 100mg Tablet while pregnant?

No. Neptaz 100mg Tablet could harm developing babies. If you're pregnant or planning pregnancy, consult your doctor before using this medication.

What are the side effects of taking Neptaz 100mg Tablet?

Common side effects include dizziness, coughing, nausea, fatigue, low blood pressure, kidney problems, and high potassium levels in your blood.

What precautions should I take when using Neptaz 100mg Tablet?

Inform your doctor about any allergies and medical history like liver or kidney disease, diabetes, dehydration, low blood pressure or a history of angioedema.

Can Neptaz 100mg Tablet interact with other medications?

Yes, it can interact with medicines like ACE inhibitors, aliskiren, potassium-sparing diuretics, potassium supplements, NSAIDs and lithium. Consult your doctor for advice.

How should I store Neptaz 100mg Tablet?

Store at room temperature away from light, heat and moisture. Keep the medicine out of reach of children and pets.

Last Updated On 27 Aug. 2026 | 9:40AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 14 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 10 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

208, Okhla Industrial Estate, Phase-III, New Delhi South Delhi DL 110020 IN

Country of origin: ITALY

Expiry on or after: January 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Novartis Pharmaceuticals Corporation. (2021). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/207620s018lbl.pdf
Entresto. (n.d.). Entresto Summary of product characteristics. https://www.ema.europa.eu/en/documents/product-information/entresto-epar-product-information_en.pdf
CARMADA. (n.d.). Sacubitril and Valsartan tablets [Report]. https://www.sanofi.in/dam/jcr:2e79c610-7644-4d4c-bf51-1651a1804410/Carmada%20PI-%20Valsartan+Secubitril-Annotated-Nov%202023.pdf
Sacubitril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB09292
Valsartan: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00177
Kido, K., Colvin, B. M., Szymanski, T. W., & Guglin, M. (2022). Sacubitril/Valsartan Off-Label uses for heart failure. Journal of Cardiac Failure, 28(7), 1185–1201. https://doi.org/10.1016/j.cardfail.2022.03.348

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

Grievance Officer

Name: Kishor Kumar

Email: grievance-officer@truemeds.in

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