Donance M 500 Tablet 10

Alembic Pharmaceuticals Ltd

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Old MRP ₹143.1

MRP ~~₹134.16~~

₹107.33

₹13.42/UNITS

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Composition

Dapagliflozin (10 Mg) + Metformin (500 Mg)

Donance M 500 Tablet 10 is used to control high blood glucose levels in people with Type 2 diabetes mellitus. It is a combination medicine that belongs to the class of anti-diabetic medications.

In addition to managing blood glucose levels, this medicine helps reduce the risk of diabetes-related complications. These complications include heart disease, kidney damage, nerve problems, blindness, limb loss, and sexual dysfunction. Regular use alongside a proper diet and exercise can improve your overall glycaemic control.

You should take this medicine exactly as prescribed by your doctor. Before starting, inform your doctor about any pre-existing conditions you have, especially kidney or liver issues, and any other medicines you are currently taking. If you notice any side effects while using this medicine, notify your doctor immediately. Continue taking the medicine for the full duration prescribed by your doctor to achieve the best results.

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Donance M 500 Tablet 10 is used for the following:

Managing Type 2 diabetes mellitus
Controlling high blood glucose levels
Reducing risk of diabetes-related heart disease
Preventing diabetes-related kidney damage
Decreasing chances of diabetes-related blindness
Preventing diabetes-related limb loss
Supporting diet and exercise for diabetes control

Follow these instructions while taking Donance M 500 Tablet 10:

Swallow the tablet whole with a full glass of water.
Do not crush, chew, or break the tablet.
Take this medicine at the same time each day for best results.
Continue taking this medicine regularly even if you feel well.
If you have any concerns about using this medicine, consult your doctor.

Donance M 500 Tablet 10 is taken orally.

Donance M 500 Tablet 10 may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Loss of appetite
Headache
Sore throat
Stuffy or runny nose
Genital fungal infections: These are yeast infections that can affect the genital area, causing itching, redness, and unusual discharge.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Donance M 500 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Nausea and vomiting: Taking Donance M 500 Tablet 10 with meals can help reduce these stomach-related side effects.
Loss of appetite: Try taking this medicine during or immediately after a meal to minimise this effect.

Donance M 500 Tablet 10 contains two active ingredients that work together to control blood glucose levels:

Dapagliflozin (10 mg): This component inhibits the sodium-glucose co-transporter-2 (SGLT2) in your kidneys. By blocking SGLT2, dapagliflozin prevents the reabsorption of glucose and promotes its excretion through urine, effectively lowering blood glucose levels.
Metformin (500 mg): As a biguanide, metformin works by decreasing glucose production in your liver. It also reduces intestinal absorption of glucose and improves insulin sensitivity in your body, helping your cells respond better to insulin and take up glucose more effectively.

Pregnancy

Be careful while taking Donance M 500 Tablet 10 if you are pregnant. Talk with your doctor before taking this medicine.

Breastfeeding

Exercise caution while taking Donance M 500 Tablet 10 if you are breastfeeding. It is ideal to discuss with your doctor before taking this medicine.

Alcohol

Avoid alcohol while taking Donance M 500 Tablet 10. Drinking alcohol with this medicine may increase your risk of developing lactic acidosis, a serious condition that affects your blood.

Liver

Caution is advised while taking Donance M 500 Tablet 10 if you have any liver problems. This medicine may affect your liver function, so tell your doctor about any existing liver conditions before starting treatment.

Kidney

Donance M 500 Tablet 10 is not recommended if you have severe kidney problems. Your doctor may need to check your kidney function before and during treatment, as this medicine is removed from your body through your kidneys.

Using Machines & Driving

You may drive and use machines while taking Donance M 500 Tablet 10. However, if you feel dizzy or experience low blood sugar, avoid these activities until you feel better.

Allergy

Tell your doctor about any allergies you have before taking Donance M 500 Tablet 10. If you notice swelling, rash, itching, or breathing problems after taking this medicine, seek medical help immediately.

Children

Take care while giving Donance M 500 Tablet 10 to children under 18. Always talk with your doctor before giving any medicine to a child.

Older Patients

Older patients should take Donance M 500 Tablet 10 under medical supervision, as they may be more sensitive to dehydration. Your doctor may monitor you more closely, especially if you have kidney problems or take other medicines.

Drug-Drug Interactions

Donance M 500 Tablet 10 interacts with the following medicines:

Diuretics: Water pills like furosemide and hydrochlorothiazide can increase the risk of dehydration when taken with Donance M 500 Tablet 10.
Antidiabetic medicines: Medicines such as glimepiride and gliclazide may enhance blood glucose-lowering effects when combined with Donance M 500 Tablet 10, potentially causing low blood sugar.
Corticosteroids: Medicines like prednisolone and dexamethasone may decrease the effectiveness of Donance M 500 Tablet 10 by raising blood glucose levels.
Calcium channel blockers: Medicines such as amlodipine and nifedipine may have altered effectiveness when taken alongside Donance M 500 Tablet 10.
Phenothiazines: Medicines like chlorpromazine and prochlorperazine may reduce the blood glucose-lowering effect of Donance M 500 Tablet 10.

Drug-Disease Interactions

Donance M 500 Tablet 10 interacts with the following diseases:

Kidney disease: This medicine should be used cautiously in patients with kidney problems, as it may worsen kidney function.
Liver dysfunction: Patients with liver problems should exercise caution as this medicine may increase the risk of lactic acidosis.
Diabetic ketoacidosis: Donance M 500 Tablet 10 is not suitable for managing this condition and may worsen the situation.
Heart failure: This medicine should be used carefully in patients with heart problems, as dapagliflozin may affect fluid balance.

Daily Dose

The daily dose of Donance M 500 Tablet 10 should be taken exactly as prescribed by your doctor. Your dosage may change based on your blood sugar levels and how well you respond to treatment.

Over Dose

Taking more than the prescribed dosage of Donance M 500 Tablet 10 may cause nausea, vomiting, stomach discomfort, and diarrhoea. You might also experience a headache and increased urination. If you suspect an overdose, contact your doctor for guidance.

Missed Dose

If you forget to take Donance M 500 Tablet 10, take it as soon as you remember. If it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never double up on doses to make up for a missed one.

Store Donance M 500 Tablet 10 at room temperature (not exceeding 25°C).
Keep away from direct sunlight, heat, and moisture.
Store it in the original packaging to protect it from environmental exposure.
Keep out of reach of children and pets.
Do not use after the expiry date printed on the package.

Follow a low-carbohydrate diet by reducing your intake of sugary foods, white bread, and rice to help maintain healthy blood glucose levels alongside your diabetes medicine.
Aim for at least 30 minutes of moderate physical activity (like brisk walking) most days of the week to improve insulin sensitivity and help control your blood sugar.

Fact Box

Available Dosage Types	Tablet SR
Habit Forming	No
Ailment	Type 2 diabetes, Hyperglycaemia
Drug Category	SGLT2 inhibitor, Biguanide
Therapeutic Category	Anti-diabetic medication

What is Donance M 500 Tablet 10 used for?

Donance M 500 Tablet 10 helps manage Type 2 diabetes in adults. It works alongside proper diet and exercise to control high blood glucose levels.

How does Donance M 500 Tablet 10 work?

It works through two mechanisms: dapagliflozin removes excess glucose through urine, while metformin reduces glucose production in your liver and improves insulin sensitivity.

Can I take Donance M 500 Tablet 10 with other diabetes medicines?

Yes, but always inform your doctor about all medicines you're taking. Donance M 500 Tablet 10 may interact with other diabetes medicines and require dosage adjustments.

What are the common side effects of Donance M 500 Tablet 10?

Common side effects include nausea, diarrhoea, headache, loss of appetite, and genital fungal infections. Staying hydrated can help reduce some of these effects.

Should I stop taking Donance M 500 Tablet 10 before surgery?

You may need to temporarily stop taking this medicine before surgery or certain medical procedures. Always consult your doctor for specific guidance.

Can I drink alcohol while taking Donance M 500 Tablet 10?

It's best to avoid alcohol while taking this medicine, as it increases your risk of low blood sugar and lactic acidosis (a rare but serious condition).

How should I store Donance M 500 Tablet 10?

Store at room temperature (not exceeding 25°C) away from direct sunlight, heat, and moisture. Keep out of reach of children and don't use after the expiry date.

Last Updated On 20 May. 2025 | 4:51PM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 9 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Alembic Road, Vadodara - 390 003, Gujarat,INDIA

Country of origin: INDIA

Expiry on or after: March 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Bailey, C. J., Gross, J. L., Hennicken, D., Iqbal, N., Mansfield, T. A., & List, J. F. (2013). Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: A randomized, double-blind, placebo-controlled 102-week trial. BMC Medicine, 11(1). https://doi.org/10.1186/1741-7015-11-43
Torrent Pharmaceuticals Ltd. (2022, May). Dapagliflozin and Metformin. https://www.torrentpharma.com/assets/GLUCRETA_SM_PI_2f4f48f1e0.pdf
Metformin: MedlinePlus drug information. (2024, February 15). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a696005.html
About dapagliflozin. (2022, March 3). https://www.nhs.uk/medicines/dapagliflozin/about-dapagliflozin/
Dapagliflozin: MedlinePlus drug information. (2024, September 20). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a614015.html

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U62099MH2019PTC320566

Telephone:09240250346

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