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CompositionGlucreta M 10+500 Tablet is used to manage type 2 diabetes and prevent complications like heart attack or stroke. This antidiabetic medicine combines dapagliflozin (SGLT2 inhibitor) and metformin (biguanide). Dapagliflozin increases the removal of sugar via the kidneys, while metformin reduces glucose production in the liver, leading to effective blood sugar control.
Glucreta M 10 + 500 Tablet is used to improve blood sugar control in adults with type 2 diabetes mellitus, combining two agents (Dapagliflozin and Metformin) to prevent severe, long-term diabetic complications, including kidney damage, nerve problems, blindness, limb amputations, sexual dysfunction, and cardiovascular events like heart attack and stroke.
Always take this medicine with food.
Swallow the tablet whole, preferably with a glass of water.
Avoid crushing, cutting or chewing the Glucreta M 10+500 Tablet.
Do not exceed the dosage recommended by your doctor.
It's important not to stop taking this medicine until you've consulted with your doctor.
Glucreta M 10+500 Tablet is taken orally.
Glucreta M 10 + 500 Tablet may cause common cold, urinary tract infections, nausea, vomiting, diarrhoea, headache, and back pain.
Here are some general guidelines for managing common side effects:
Nausea: Try taking Glucreta M 10+500 Tablet with food to lessen this effect.
Diarrhoea: Consider taking this medicine in the morning, this can help manage your symptoms throughout the day.
Glucreta M 10+500 Tablet consists of two components:
Dapagliflozin (10 mg): This belongs to the class of SGLT2 inhibitors. Its function is primarily to increase the removal of sugar by the kidneys, hence reducing the amount of sugar absorbed back into the body.
Metformin (500 mg): As a biguanide antihyperglycemic agent, metformin works by decreasing sugar production in the liver and reducing sugar absorption in the gut.
These two ingredients work together to improve the body's response to insulin and overall blood sugar control.
If you are pregnant, caution is advised while taking this medicine. It is best to consult your doctor before taking this medicine.
If you are breastfeeding, it's recommended to discontinue Glucreta M 10+500 Tablet. Your doctor can guide you about the potential risks and benefits.
Alcohol consumption can increase the risk of lactic acidosis with Glucreta M 10+500 Tablet. It's safer to avoid alcohol while taking this medicine.
If you have liver problems, discuss them with your doctor before starting Glucreta M 10+500 Tablet. Liver impairment can increase the risk of lactic acidosis with this medicine.
Glucreta M 10+500 Tablet is not recommended for severe kidney diseases or end-stage renal disease requiring dialysis. If you have a history of any kidney problems, it's a good idea to consult your doctor before taking this medicine.
No specific precautions are required while using machines or driving when taking Glucreta M 10+500 Tablet. However, if you experience side effects like dizziness or sleepiness, be careful while doing activities that require alertness.
If you have had serious hypersensitivity reactions to dapagliflozin or metformin in the past, Glucreta M 10+500 Tablet is contraindicated. Ensure your doctor knows about any allergies you have had.
Glucreta M 10+500 Tablet is not safe to use in children under 18 years old. Always consult your doctor before giving any medicine to a child.
Older patients should take Glucreta M 10+500 Tablet under medical supervision as they may be more susceptible to its side effects, particularly hypoglycaemia and kidney problems. It's important to discuss this with your doctor before starting the medicine.
Insulin and insulin secretagogues: When combined with Glucreta M 10+500 Tablet, medicines like insulin or glimepiride may significantly lower blood sugar, leading to a condition called hypoglycaemia.
Diuretics: Medications like furosemide or hydrochlorothiazide, when used with Glucreta M 10+500 Tablet, may increase your risk of lactic acidosis due to possible kidney function impairment.
Corticosteroids: Medicines such as prednisone or dexamethasone can affect blood glucose levels and may reduce the effectiveness of this medication.
Oral contraceptives: Hormonal contraceptives like ethinyl estradiol or levonorgestrel may interfere with the blood sugar-lowering effect of Glucreta M 10+500 Tablet.
Consuming alcohol while taking Glucreta M 10+500 Tablet can greatly increase the risk of lactic acidosis.
Kidney disease: Patients with severe kidney impairment or end-stage renal disease should avoid this medication as it can exacerbate their condition.
Liver disease: Individuals with liver disease need to exercise caution as this medicine could worsen their condition.
Heart failure: This tablet should be used judiciously in patients suffering from heart failure due to potential volume depletion effects.
The daily dose of Glucreta M 10+500 Tablet should be taken as prescribed by your doctor. The dosage may vary based on individual factors such as the severity of your condition and your response to treatment. Always follow the prescribed dosage and never exceed it without consulting your doctor.
If you accidentally take more than the prescribed dose of Glucreta M 10+500 Tablet, some common symptoms may include feeling excessively nauseous or experiencing severe diarrhoea. If these symptoms persist, please inform your doctor.
If you forget to take your Glucreta M 10+500 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your usual schedule. Never double up on doses without consulting your doctor.
Keep Glucreta M 10+500 Tablet at room temperature, ideally between 20°C to 25°C.
Protect the medicine from light and moisture, storing it in a tightly closed container.
Make sure it's out of reach of children.
Always check the expiry date and use the medicine before it expires.
Regular physical activity: Engaging in moderate exercise like brisk walking can aid in controlling blood sugar levels when you're managing type 2 diabetes with Glucreta M 10+500 Tablet. However, consult your doctor before starting any new exercise regimen.
Balanced diet: Consuming a balanced diet rich in fibre (fruits, vegetables, whole grains) and lean proteins can help manage high blood sugar. Avoid processed food and drinks high in sugar.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Type 2 Diabetes Mellitus |
| Drug Category | SGLT2 Inhibitor, Biguanide |
| Therapeutic Category | Antidiabetic |
Glucreta M 10+500 Tablet is used to improve blood sugar control in adults with type 2 diabetes, alongside a healthy diet and regular exercise.
The medicine works by restoring the body's response to insulin, reducing sugar production in the liver, enhancing sugar removal by the kidneys, and decreasing sugar absorption in the gut.
You should take the tablet whole with food in the morning. Do not crush, cut or chew it. Always consult your doctor for specific instructions.
Common side effects include fungal infections, urinary tract infection, nausea, vomiting, diarrhoea, headache, back pain and upper respiratory tract infection.
If you have severe kidney impairment or end-stage renal disease requiring dialysis, this medicine is not recommended. Consult your doctor for alternatives.
Drinking alcohol while taking this medicine is not advisable as it may increase the risk of lactic acidosis. Always consult your doctor before consuming alcohol.
If you suspect an overdose, immediately stop taking the medicine and seek medical help. Symptoms may include low blood sugar and lactic acidosis.
Check out Editorial Policy
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2014). [Press-release]. XIGDUO XR. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/205649s008lbl.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AstraZeneca. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Dapagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06292
Bailey, C. J., Gross, J. L., Hennicken, D., Iqbal, N., Mansfield, T. A., & List, J. F. (2013). Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Medicine, 11(1). https://doi.org/10.1186/1741-7015-11-43
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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