Dapagliflozin + Metformin

Dosage Forms Available

• Dapagliflozin + Metformin is available as oral tablets.

Age and Dose Restrictions

• This combination is not recommended for children below 18 years of age. The dosage may be adjusted based on the patient’s condition and kidney function.

Contraindications

• Dapagliflozin + Metformin is contraindicated in patients with severe kidney disease, diabetic ketoacidosis, dehydration, or allergy to any of its components. It should not be used in individuals with severe liver impairment.

Other Medications to Avoid

• Avoid taking this combination with diuretics (furosemide, hydrochlorothiazide), corticosteroids (prednisolone), beta-blockers (propranolol), NSAIDs (ibuprofen), and other antidiabetic medications (sulfonylureas, insulin) as they may increase the risk of dehydration, kidney issues, or hypoglycemia. Always inform your doctor about any medications you are taking.

Overdose and Missed Dose

• An overdose of this combination can lead to lactic acidosis, dehydration, and severe hypoglycemia. Seek immediate medical attention if an overdose occurs.
• If you miss a dose, take it as soon as you remember. If it is close to your next dose, skip the missed dose and continue your regular schedule. Do not double the dose to make up for the missed one.

Management of Side Effects

• To manage urinary tract infections, drink plenty of water and practice good hygiene. For nausea or diarrhea, take the medication with food and consult a doctor if symptoms persist. If hypoglycemia occurs, consume fast-acting sugar sources like fruit juice, candy, or glucose tablets to stabilize blood sugar levels.

Use in Driving and Operating Machinery

• Dapagliflozin + Metformin may cause dizziness or fatigue. Avoid driving or operating heavy machinery until you understand how this medication affects you.

Use in Pregnancy and Lactation

• This combination is not recommended during pregnancy and breastfeeding due to potential risks to the baby. Speak with your doctor about safer alternatives.

Caution in Other Conditions

• Use this combination with caution in patients with kidney or liver disease, dehydration, low blood pressure, a history of urinary tract infections, or ketoacidosis. Watch for symptoms like nausea, vomiting, abdominal pain, or rapid breathing, which may indicate diabetic ketoacidosis.

Special Dietary and Lifestyle Recommendations

• Follow a low-glycemic index diet, including green leafy vegetables, whole grains, berries, and lean proteins.
• Stay well-hydrated to prevent dehydration caused by increased urination.
• Engage in regular physical activity to improve insulin sensitivity and overall blood sugar control.