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CompositionDaparyl-M Tablet is used to manage type 2 diabetes mellitus in adults. It is a combination medicine containing dapagliflozin and metformin, to help control blood sugar. It works through two complementary mechanisms to improve glycemic control. Take this medicine as directed, informing your doctor of any pre-existing conditions or medications. If side effects occur, notify your doctor immediately.
Daparyl-M Tablet is used to treat type 2 diabetes mellitus. It helps lower blood sugar by increasing glucose excretion through urine, reducing intestinal absorption of glucose, decreasing glucose production in the liver, and improving insulin sensitivity and glucose utilization. The medicine is intended to support overall blood sugar control when combined with a healthy diet, exercise, and other prescribed antidiabetic treatments.
Here are some general instructions on how to take Daparyl-M 10/500 Tablet:
Swallow the tablet whole with plenty of water.
Avoid chewing or crushing the tablet.
Always take this medicine regularly as prescribed, even if you feel well.
Do not stop taking this medicine without consulting your doctor first.
Daparyl-M 10/500 Tablet is taken orally.
Daparyl-M Tablet may cause genital fungal infections, urinary tract infections, nasopharyngitis (inflammation of the nose and throat), headaches, nausea, diarrhea, and low blood sugar, which can lead to weakness, dizziness, or confusion.
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Daparyl-M 10/500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Diarrhoea: Consume plenty of water and healthy fluids to avoid dehydration.
Hypoglycaemia: If you feel dizzy or weak, have a small snack or drink something sugary. Remember to monitor your blood sugar levels regularly.
Daparyl-M 10/500 Tablet contains two active ingredients:
Dapagliflozin (10 mg): This is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. Its job is to reduce renal glucose reabsorption, which increases urinary glucose excretion and lowers blood glucose levels.
Metformin (500 mg): This biguanide works by decreasing hepatic glucose production, reducing intestinal absorption of glucose, and improving insulin sensitivity all of which contribute to lowering blood glucose levels and improving glycemic control.
Daparyl-M 10/500 Tablet is not recommended during pregnancy. If you're pregnant or planning to conceive, it's crucial to discuss this with your doctor before starting the medication.
This medicine is not recommended for breastfeeding women. It's best to consult your doctor to understand the potential risks and benefits if you are lactating.
Avoid excessive alcohol consumption while taking Daparyl-M 10/500 Tablet, as it might increase the risk of lactic acidosis, a rare but serious side effect associated with metformin.
Caution is advised when taking this medicine if you have mild to moderate liver impairment. It's not recommended for severe liver diseases. Discuss your liver health with your doctor before starting Daparyl-M 10/500 Tablet.
Daparyl-M 10/500 Tablet should not be used in patients with severe kidney impairment. If you have any kidney problems, it's best to consult your doctor before taking this medication.
No specific precautions are suggested while using machines or driving when taking Daparyl-M 10/500 Tablet. However, follow your doctor’s advice.
If you have a history of serious hypersensitivity reaction to dapagliflozin, metformin, or any of the other ingredients in Daparyl-M 10/500 Tablet, avoid taking this medication.
This medicine isn't advised for children under 18 years of age. Always consult your doctor before giving any medicine to a child.
Older patients should take Daparyl-M 10/500 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.
Daparyl-M 10/500 Tablet interacts with the following medicines:
Diuretics: Medicines like furosemide or hydrochlorothiazide may increase the risk of dehydration and low blood pressure when taken with Daparyl-M 10/500 Tablet.
Insulin or insulin secretagogues: These medicines, such as glimepiride or glyburide, could intensify the risk of low blood sugar when combined with Daparyl-M 10/500 Tablet. Dosage adjustments might be necessary.
Cationic medications: Medicines like amiloride, digoxin, and ranitidine can reduce metformin's removal from your body. Regular monitoring is recommended.
Certain foods can interact with Daparyl-M 10/500 Tablet:
High-fat meals: These can slow down the absorption of dapagliflozin, decreasing its effectiveness.
Daparyl-M 10/500 Tablet interacts with the following diseases:
Renal impairment: If you have kidney problems, this medicine could exacerbate your condition.
Hepatic impairment: Those with liver disease should be cautious as Daparyl-M 10/500 Tablet could worsen their condition.
Genital mycotic infections: If you've previously had genital yeast infections, Daparyl-M 10/500 Tablet might increase the risk of recurrence.
Your doctor will guide you on the right daily dose of Daparyl-M 10/500 Tablet. The dosage may vary based on factors like your health condition and how well your body responds to the medication. Always adhere to the prescribed dosage and never change it without consulting your doctor.
An overdose of Daparyl-M 10/500 Tablet may cause symptoms such as nausea, diarrhoea, or headaches. If you accidentally take more than your prescribed dose, inform your doctor about it.
If you've forgotten to take your scheduled dose of Daparyl-M 10/500 Tablet, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and maintain your regular dosing schedule. Don't alter your dosage without discussing with your doctor.
Store Daparyl-M 10/500 Tablet at room temperature, ideally below 30°C.
Keep the tablet in a tightly closed container to protect it from moisture and light.
Always keep this medicine out of reach of children.
Remember to use the tablet before its expiry date.
Regular exercise: Try to include physical activities like walking or cycling in your daily routine. Regular exercise can help manage blood sugar levels, which is crucial if you're taking Daparyl-M 10/500 Tablet for type 2 diabetes.
Balanced diet: Include fibre-rich foods like whole grains, fruits and vegetables in your meals. At the same time, reduce your intake of sugary foods and drinks. A balanced diet can aid in maintaining healthy blood sugar levels.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Type 2 Diabetes Mellitus |
| Drug Category | SGLT2 Inhibitor, Biguanide |
| Therapeutic Category | Antidiabetic |
Daparyl-M 10/500 Tablet is used to manage blood sugar levels in adults with type 2 diabetes, alongside a suitable diet and exercise routine.
The medicine combines dapagliflozin and metformin, which work together to reduce blood sugar. Dapagliflozin increases sugar excretion in urine, while metformin decreases sugar production and absorption.
You should take this tablet orally as advised by your doctor. Always swallow the tablet whole with water, without crushing or chewing it.
Common side effects include genital infections, urinary tract infections, nasopharyngitis (common cold), headache, nausea, diarrhoea, and hypoglycaemia (low blood sugar).
Inform your doctor about any existing kidney or liver issues, history of genital or urinary infections, and any other medicines or supplements you're taking.
Yes, it's not advisable to take this medicine if you have severe kidney impairment, metabolic acidosis including diabetic ketoacidosis, or have had serious allergic reactions to its ingredients.
Store the tablets at room temperature, away from light and moisture. Always keep the container tightly closed and out of children's reach.
Check out Editorial Policy
HIGHLIGHTS OF PRESCRIBING INFORMATION. (2014). [Press-release]. XIGDUO XR. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/205649s008lbl.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AstraZeneca. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Dapagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06292
Bailey, C. J., Gross, J. L., Hennicken, D., Iqbal, N., Mansfield, T. A., & List, J. F. (2013). Dapagliflozin add-on to metformin in type 2 diabetes inadequately controlled with metformin: a randomized, double-blind, placebo-controlled 102-week trial. BMC Medicine, 11(1). https://doi.org/10.1186/1741-7015-11-43
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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