Noltrexate 7.5 Tablet 10

Knoll Healthcare Pvt. Ltd.

Strip of 10 Units

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MRP ~~₹145.5~~

₹116.4

₹14.55/Units

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Composition

Methotrexate (7.5 Mg)

Strength:

7.5 MG 2.5 MG 5 MG 10 MG

Noltrexate 7.5 Tablet 10 is primarily used to manage various types of cancers. This medicine is a member of the antimetabolite class of medications.

Aside from cancer, this tablet is also used to manage severe cases of rheumatoid arthritis, psoriasis, and Crohn's disease that haven't responded adequately to other treatments.

Before you begin taking this medication, it's important to consult your doctor about the appropriate dosage and frequency. Make sure to inform your doctor about any preexisting conditions or current medications. While on this medicine, keep your doctor informed about any side effects you might experience. For optimal results, continue taking the medication for the entire duration prescribed by your doctor.

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Noltrexate 7.5 Tablet 10 is used to treat cancers such as breast, lung, bone, uterine, leukemia, lymphoma, and head and neck cancers. It also helps manage autoimmune conditions like rheumatoid arthritis, juvenile idiopathic arthritis, severe psoriasis, and Crohn’s disease.

When taking Noltrexate 7.5 Tablet 10, follow these guidelines:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Do not exceed the recommended dose without consulting your doctor.
It is crucial not to discontinue this medicine without speaking to your doctor first.

Noltrexate 7.5 Tablet 10 is taken orally.

Noltrexate 7.5 Tablet 10 may have the following common side effects:

Ulcerative stomatitis: This can cause painful sores in your mouth.
Hair loss
Low blood cell counts: This might make you more prone to infections and fatigue.
Elevated liver enzymes: This could indicate possible liver damage.
Nausea
Abdominal discomfort

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Noltrexate 7.5 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Noltrexate 7.5 Tablet 10 with food or milk to lessen this feeling of sickness.
Abdominal discomfort: Consider taking this medicine after meals to reduce stomach upset.

Noltrexate 7.5 Tablet 10 contains methotrexate (7.5 mg), which acts on your body in the following ways:

Inhibits Dihydrofolate Reductase: Methotrexate works by blocking an enzyme in your body called dihydrofolate reductase. This enzyme plays a key role in the creation of DNA and RNA in your cells.
Slows Cell Division: By inhibiting dihydrofolate reductase, methotrexate effectively slows down the growth and multiplication of rapidly dividing cells such as cancer cells and immune system cells that cause inflammation in conditions like rheumatoid arthritis and psoriasis.

Pregnancy

Is it safe to use Noltrexate 7.5 Tablet 10 during pregnancy?

Noltrexate 7.5 Tablet 10 is contraindicated if you are pregnant. If you are pregnant or planning to conceive, it's crucial to consult your doctor before starting this medicine.

Breastfeeding

Is it safe to consume Noltrexate 7.5 Tablet 10 during breastfeeding?

Noltrexate 7.5 Tablet 10 is contraindicated for breastfeeding women. Make sure to discuss this with your doctor to understand the potential risks and benefits.

Alcohol

Is it safe to drink alcohol while taking Noltrexate 7.5 Tablet 10?

Caution is advised when drinking alcohol while taking Noltrexate 7.5 Tablet 10, as it can increase the risk of liver damage. It's best to consult your doctor before taking this medicine.

Liver

Is it advisable to take Noltrexate 7.5 Tablet 10 when experiencing liver problems?

Caution is advised while taking Noltrexate 7.5 Tablet 10 if you have mild to moderate liver impairment. This medicine is not recommended for severe liver diseases. If you have any liver problems, discuss them with your doctor before starting this medication.

Kidney

Is it advisable to consume Noltrexate 7.5 Tablet 10 when experiencing kidney problems?

If you have a history of kidney problems, consult your doctor before taking Noltrexate 7.5 Tablet 10.

Using Machines & Driving

Is it safe to operate heavy machinery or drive when using Noltrexate 7.5 Tablet 10?

Noltrexate 7.5 Tablet 10 may cause dizziness, drowsiness, or visual disturbances. Exercise caution while driving or operating machinery when taking this medicine.

Allergy

Are there any specific conditions that should be considered before taking Noltrexate 7.5 Tablet 10?

If you have a known allergy to methotrexate or any other components of Noltrexate 7.5 Tablet 10, it's best not to take this medicine without consulting your doctor.

Children

Is Noltrexate 7.5 Tablet 10 suitable for infants or children?

Noltrexate 7.5 Tablet 10 should not be given to children under the age of 18 years unless prescribed by a doctor.

Older Patients

Is Noltrexate 7.5 Tablet 10 suitable for older patients?

Older patients should take Noltrexate 7.5 Tablet 10 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Noltrexate 7.5 Tablet 10 interacts with the following medicines:

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Medicines like ibuprofen and naproxen may interact with Noltrexate 7.5 Tablet 10, potentially increasing the risk of side effects.
Certain Antibiotics: Penicillins (like amoxicillin), sulfonamides (like sulfadiazine and sulfamethizole), or trimethoprim/sulfamethoxazole may interact with this tablet, altering its absorption and effectiveness.
Proton pump inhibitors (PPIs): Medicines like omeprazole or lansoprazole may affect the absorption of this tablet.
Antiseizure medications: Phenytoin, when taken alongside Noltrexate 7.5 Tablet 10, can alter the latter's effectiveness.

Drug-Food Interactions

There are no specific food items known to interact significantly with Noltrexate 7.5 Tablet 10.

Drug-Disease Interactions

Noltrexate 7.5 Tablet 10 interacts with the following diseases:

Liver Disease: Patients with liver disease should exercise caution while taking this medicine as it could potentially worsen their condition.
Kidney Disease: Caution is advised for those with kidney disease as this tablet might affect kidney function.
Immune System Disorders: Due to its potential to suppress the immune system, careful monitoring is required when using Noltrexate 7.5 Tablet 10 in patients with immune disorders.

Daily Dose

The daily dose of Noltrexate 7.5 Tablet 10 should be taken as prescribed by your doctor. Follow the prescribed dosage and consult your doctor before making any changes.

Over Dose

If you accidentally take more than the prescribed dose of Noltrexate 7.5 Tablet 10, you may experience symptoms like nausea or abdominal discomfort. If these symptoms persist or worsen, inform your doctor.

Missed Dose

In case you forget to take your regular dose of Noltrexate 7.5 Tablet 10, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with your regular dosage schedule. Avoid increasing your dosage without consulting your doctor.

Store Noltrexate 7.5 Tablet 10 at room temperature.
Keep it away from direct sunlight and moisture.
Ensure the medicine is kept out of reach and sight of children.
Always check the expiry date before taking the medicine.

If you're managing rheumatoid arthritis with Noltrexate 7.5 Tablet 10, a balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support your overall health.
As this medicine is used for psoriasis management, reducing alcohol consumption can help lower the chances of triggering a psoriasis flare-up.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Breast cancer, Rheumatoid arthritis, Psoriasis
Drug Category	Antimetabolite
Therapeutic Category	Antineoplastic Medicine

What is Noltrexate 7.5 Tablet 10 used for?

It's used to manage various cancers, severe rheumatoid arthritis, psoriasis, and Crohn's disease that haven't responded well to other treatments.

How does Noltrexate 7.5 Tablet 10 work?

It slows the growth of rapidly dividing cells, like cancer cells and immune system cells, causing inflammation by inhibiting a key enzyme.

Can I take Noltrexate 7.5 Tablet 10 every day?

This medicine should be taken as per your doctor's prescription.

What are the common side effects of Noltrexate 7.5 Tablet 10?

Common side effects include mouth sores, hair loss, low blood cell counts, elevated liver enzymes, nausea, and abdominal discomfort.

Is it safe to drive after taking Noltrexate 7.5 Tablet 10?

Be cautious, as this medicine may cause dizziness, drowsiness, or visual disturbances, which can affect your ability to drive or operate machinery.

Can I consume alcohol while taking Noltrexate 7.5 Tablet 10?

No, you should avoid alcohol, as it can increase the risk of liver damage when you're on this medication.

Can I take other medicines while on Noltrexate 7.5 Tablet 10?

Some medicines like ibuprofen and amoxicillin can interact with methotrexate; inform your doctor about all medications you're taking before starting this therapy.

Who should not take Noltrexate 7.5 Tablet 10?

Noltrexate 7.5 Tablet 10 should not be taken by individuals who are allergic to methotrexate or any of its ingredients, pregnant or breastfeeding women, patients with severe liver or kidney disorders, low white blood cell or platelet counts, bone marrow disorders, active infections, or those who have recently received live vaccines. Caution is also advised for people with lung, blood, or gastric disorders and those who consume excessive alcohol.

Is Noltrexate 7.5 Tablet 10 an immunosuppressant?

Yes, Noltrexate 7.5 Tablet 10 contains methotrexate, which is an immunosuppressant drug used primarily to treat autoimmune conditions like rheumatoid arthritis and severe psoriasis by suppressing the immune system's overactivity.

Last Updated On 09 Oct. 2025 | 7:45AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

M17, Pharma Tower,, Phase-1, Badli Industrial Area,, Badli, Delhi, 110042

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

West-Ward Pharmaceuticals Corp. (2020). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf
Methotrexate: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00563
DailyMed - METHOTREXATE SODIUM tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89c05ea3-3be1-46dd-b112-29c436fd7289
Methotrexate sodium (Cancer treatment). (2008, May 21). Cancer.gov. https://www.cancer.gov/about-cancer/treatment/drugs/methotrexate
Onda, K., Honma, T., & Masuyama, K. (2023). Methotrexate-related adverse events and impact of concomitant treatment with folic acid and tumor necrosis factor-alpha inhibitors: An assessment using the FDA adverse event reporting system. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1030832

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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