Prucalopride 2 Tablet 10

Knoll Healthcare Pvt. Ltd.

Strip of 10 Units

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MRP ~~₹380.5~~

₹189.87

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Composition

Prucalopride (2 Mg)

Prucalopride-2 Tablet is primarily used to manage chronic idiopathic constipation (CIC) in adults. This medication falls under the category of selective serotonin 5HT4 receptor agonists.

This tablet is beneficial for individuals who encounter continual or recurring constipation despite trying other laxatives. It helps alleviate the discomfort and distress caused by this persistent condition.

Before taking this medicine, it's crucial to consult your doctor about the appropriate dosage and frequency. Make sure you inform your doctor about any existing medical conditions or ongoing medications you are on. If you see any side effects while using this medicine, contact your doctor immediately. Continue with the medication for the period your doctor has prescribed for maximum benefits.

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Prucalopride Tablet is a gastrointestinal prokinetic used to treat chronic idiopathic constipation (CIC) in adults when laxatives fail. It works by stimulating bowel motility, improving bowel movements, and providing relief from discomfort, thus restoring normal bowel function and helping manage CIC effectively.

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
The medicine can be taken with or without food.
It's important not to exceed the dose prescribed by your doctor.

Prucalopride-2 Tablet is taken orally.

Prucalopride-2 Tablet may have the following common side effects:

Headache
Abdominal pain
Nausea
Diarrhea
Abdominal distension
Dizziness
Vomiting
Flatulence
Fatigue

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolves on discontinuing the use of Prucalopride-2 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Prucalopride-2 Tablet with food to lessen this effect.
Diarrhoea: Ensure that you stay hydrated by drinking lots of fluids.

Prucalopride-2 Tablet contains prucalopride (2 mg), which works in the body as follows:

Activates Serotonin 5 HT4 Receptors: Prucalopride acts as a highly selective serotonin 5 HT4 receptor agonist. It activates these specific receptors in your body.
Enhances Acetylcholine Release: By stimulating the serotonin 5 HT4 receptors, prucalopride indirectly enhances the release of acetylcholine. This neurotransmitter boosts intestinal motility, effectively managing chronic constipation by promoting bowel movements.

Pregnancy

Exercise caution while taking Prucalopride-2 Tablet if you're pregnant. It is best to consult your doctor before taking this medicine to weigh the potential benefits against any potential risks.

Breastfeeding

As a precaution, it's advisable to consult your doctor before taking Prucalopride-2 Tablet while breastfeeding. Prucalopride is present in breast milk. However, there are no data on the effects of prucalopride on the breastfed child or its effects on milk production.

Alcohol

The interaction of Prucalopride-2 Tablet with alcohol is unknown. It's always a good idea to consult your doctor about consuming alcohol while on this medication.

Liver

No dose adjustment is required for patients with hepatic impairment. However, as liver conditions can be complex, it's always wise to discuss your liver health with your doctor before starting Prucalopride-2 Tablet.

Kidney

Prucalopride-2 Tablet should not be used by patients with severe renal impairment. If you have any kidney health issues, please consult your doctor before taking this medication.

Using Machines & Driving

There are no known restrictions on using machinery or driving while taking Prucalopride-2 Tablet. However, if you experience side effects like dizziness, refrain from such activities and inform your doctor.

Allergy

Prucalopride-2 Tablet should not be taken if you have hypersensitivity or allergy to prucalopride. Always tell your doctor about any allergies before starting a new medicine.

Children

The safety and effectiveness of Prucalopride-2 Tablet in children have not been established yet. It's advisable not to give this medicine to children under 18 years of age unless directed by a doctor.

Older Patients

Prucalopride-2 Tablet can be used by older patients without any specific concerns. However, elderly patients may be more sensitive to medication effects, so a cautious approach is recommended when starting this medicine.

Daily Dose

Take the daily recommended dose of Prucalopride-2 Tablet as prescribed by your doctor. The dosage might change based on your individual response and the severity of your condition. It's crucial not to exceed the prescribed dosage without consulting your doctor.

Over Dose

Overdosing on Prucalopride-2 Tablet can lead to symptoms like nausea, headache, and diarrhoea. If you suspect you've taken more than prescribed, inform your doctor. Do not panic; just follow their advice.

Missed Dose

If you forget to take a dose of Prucalopride-2 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your normal schedule. Never increase your dosage without consulting your doctor.

Keep Prucalopride-2 Tablet at a controlled room temperature, ideally below 30°C.
Protect the medicine from sunlight and moisture; store it in its original packaging.
Safely keep it out of reach of children to prevent accidental ingestion.
Always remember to use the medicine before its expiry date for maximum effectiveness.

Ensure you maintain a balanced diet rich in fibre. Foods like whole grains, fruits, vegetables, and legumes can encourage regular bowel movements and help manage chronic constipation.
Regular physical activity, such as walking or cycling, can also stimulate your intestines and help manage constipation. Try to incorporate daily exercise into your routine where possible.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Chronic Idiopathic Constipation
Drug Category	Serotonin 5 HT4 Receptor Agonist
Therapeutic Category	Gastrointestinal Agent

What is Prucalopride-2 Tablet used for?

Prucalopride-2 Tablet manages chronic idiopathic constipation (CIC) in adults, when other laxatives have not provided adequate relief.

How does Prucalopride-2 Tablet work?

It works as a serotonin 5HT4 receptor agonist, promoting bowel movements by enhancing the release of a neurotransmitter called acetylcholine.

When should I take Prucalopride-2 Tablet?

The medicine is taken orally. However, always follow your doctor's instructions regarding the timing and method of intake.

How long does Prucalopride-2 Tablet take to work?

After oral intake, prucalopride might take within 2-4 hours, promoting bowel movements effectively.

What are possible side effects of Prucalopride-2 Tablet?

Common side effects include headache, abdominal pain, nausea, diarrhoea, abdominal distension, dizziness, vomiting, flatulence, and fatigue. Contact your doctor if these persist or worsen.

Are there any precautions before taking Prucalopride-2 Tablet?

Use with caution if you have a history of cardiovascular disease. It's contraindicated for severe renal impairment and certain bowel conditions.

Can I take Prucalopride-2 Tablet while pregnant or breastfeeding?

Use only if the potential benefit justifies the potential risk to the fetus or infant. Always consult your doctor before starting any medication.

Last Updated On 13 May. 2025 | 11:00AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

M17, Pharma Tower,, Phase-1, Badli Industrial Area,, Badli, Delhi, 110042

Country of origin: INDIA

Expiry on or after: October 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Shire. (2018). Highlights of prescribing information for motegrity [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/210166s000lbl.pdf
Prucalopride: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a619011.html
DailyMed - MOTEGRITY- prucalopride tablet, film coated. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=bca1e4c6-4b2b-4876-8ab3-654629c4ff1b
Prucalopride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06480

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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