Methotrexate

Dosage Forms Available

• Methotrexate is available for use via the oral route (tablet, capsule, oral solution).

Age and Dose Restrictions

• This medicine is meant for adults and children, depending on the weight and age, as a doctor recommends.

Contraindications

• The medication is not recommended in patients with a known allergy to Methotrexate and severe kidney and liver conditions.

Other Medications to Avoid

• Methotrexate may interact with painkillers (celecoxib, acetaminophen, hydrocodone), antidepressants (duloxetine), immunosuppressants (etanercept), anti-rheumatoid medications (adalimumab), antacids (esomeprazole), and anti-malarial medications (hydroxychloroquine).

Overdose and Missed Dose

• An overdose of this medication may cause symptoms like sore throat, mouth ulcers, fever, dry persistent cough, vomiting or diarrhoea. If you observe these symptoms, inform your doctor and follow the advice accordingly.
• If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Management of Side Effects

• Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use in Driving and Operating Machinery

• This medication may impair your ability to drive and operate heavy machinery.

Use in Pregnancy and Lactation

• Methotrexate is not recommended for use in pregnancy and breastfeeding unless recommended by your doctor.

Caution in Other Conditions

• Inform your doctor if you have any immunodeficiency conditions, bone marrow disorders, low white blood cell or platelet count, severe anemia, liver problems caused by alcohol abuse, or chronic liver disease.

Special Dietary and Lifestyle Recommendations

• Manage stress effectively and ensure adequate sleep for overall well-being. Proper rest helps relax muscles and reduces joint inflammation. 
• Avoid alcohol and smoking, as they can worsen symptoms. Include flavonoid-rich foods like soy, berries, broccoli, and grapes to help reduce swelling and pain. 
• Consume omega-3 fatty acid-rich foods such as berries, cherries, leafy greens, salmon, and sardines. Incorporate antioxidant-rich foods like cumin, ginger, and thyme into your diet. 
• Regular blood tests, along with liver and kidney function tests, are recommended to monitor your condition. 
• Stay well-hydrated while taking this medication to prevent severe water deficiency. If advised by your doctor, take folic acid to help reduce the severity of side effects.