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Methotrexate

Anti-Metabolites / Immunosuppressants

Uses of Methotrexate

  • Methotrexate is used to treat various types of arthritis, such as rheumatoid arthritis, psoriatic arthritis, reactive arthritis, vasculitis, enteropathic arthritis, myositis, and systemic sclerosis. It belongs to the antimetabolite group of medicines.
  • It can also be given to children who have juvenile idiopathic arthritis, systemic lupus erythematosus, juvenile dermatomyositis, vasculitis, uveitis, and localised scleroderma.
     

Side effects of Methotrexate

  • Headache
  • Vomiting 
  • Diarrhoea
  • Dizziness
  • Nausea

How Methotrexate works

  • Methotrexate is an antimetabolite medicine that exerts its therapeutic effects by inhibiting dihydrofolate reductase, an enzyme essential for folic acid metabolism. By disrupting this pathway, methotrexate hampers the synthesis of DNA, RNA, and proteins, crucial cell replication components. Consequently, it suppresses the abnormal immune response responsible for inflammation in conditions like rheumatoid arthritis. Methotrexate's immunosuppressive and anti-inflammatory actions contribute to its effectiveness in managing autoimmune diseases, making it a cornerstone in treating various inflammatory conditions.

Certified content

Written By

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Amit SharmaMedical Content Writer| 4 years

B. Pharm

Reviewed By

Amatul Ameen
Amatul Ameen Medical Content Writer| 13 years

B. Pharm, MSc.

Expert Advice

Dosage Forms Available

  • Methotrexate is available for use via the oral route (tablet, capsule, oral solution).

Age and Dose Restrictions

  • This medicine is meant for adults and children, depending on the weight and age, as a doctor recommends.

Contraindications

  • The medication is not recommended in patients with a known allergy to Methotrexate and severe kidney and liver conditions.

Other Medications to Avoid

  • Methotrexate may interact with painkillers (celecoxib, acetaminophen, hydrocodone), antidepressants (duloxetine), immunosuppressants (etanercept), anti-rheumatoid medications (adalimumab), antacids (esomeprazole), and anti-malarial medications (hydroxychloroquine).

Overdose and Missed Dose

  • An overdose of this medication may cause symptoms like sore throat, mouth ulcers, fever, dry persistent cough, vomiting or diarrhoea. If you observe these symptoms, inform your doctor and follow the advice accordingly.
  • If you forget to take this medicine, take it as soon as you remember. But avoid repeating the dose.

Management of Side Effects

  • Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Use in Driving and Operating Machinery

  • This medication may impair your ability to drive and operate heavy machinery.

Use in Pregnancy and Lactation

  • Methotrexate is not recommended for use in pregnancy and breastfeeding unless recommended by your doctor.

Caution in Other Conditions

  • Inform your doctor if you have any immunodeficiency conditions, bone marrow disorders, low white blood cell or platelet count, severe anemia, liver problems caused by alcohol abuse, or chronic liver disease.

Special Dietary and Lifestyle Recommendations

  • Manage stress effectively and ensure adequate sleep for overall well-being. Proper rest helps relax muscles and reduces joint inflammation. 
  • Avoid alcohol and smoking, as they can worsen symptoms. Include flavonoid-rich foods like soy, berries, broccoli, and grapes to help reduce swelling and pain. 
  • Consume omega-3 fatty acid-rich foods such as berries, cherries, leafy greens, salmon, and sardines. Incorporate antioxidant-rich foods like cumin, ginger, and thyme into your diet. 
  • Regular blood tests, along with liver and kidney function tests, are recommended to monitor your condition. 
  • Stay well-hydrated while taking this medication to prevent severe water deficiency. If advised by your doctor, take folic acid to help reduce the severity of side effects.

Frequently asked questions

Methotrexate may take several weeks to show noticeable effects, with full benefits often observed after 6 to 12 weeks of consistent use.

Avoid alcohol, as it can increase the risk of liver damage. Regular blood tests are required to monitor liver, kidney, and blood cell levels. Inform your doctor if you have an infection, lung issues, or a weakened immune system.

No, stopping Methotrexate abruptly without consulting your doctor can cause symptom flare-ups and complications. Always follow your doctor’s guidance before making any changes to the dosage.

Methotrexate should be used with caution in patients with kidney or liver conditions, as it may worsen these issues. Depending on your doctor's assessment, dose adjustments or alternative treatments may be necessary.

Methotrexate may temporarily affect fertility in both men and women. It is also not safe during pregnancy, as it can cause birth defects. Consult your doctor if you plan to conceive.

Terms & Conditions

List of Medicines for Methotrexate

Noltrexate 10 Tablet 10
Noltrexate 10 Tablet 10
Knoll Healthcare Pvt. Ltd.
Pack of 10 Units
₹69.36
MRP ₹139
50.1% OFF
Folitrax 15 Tablet 10
Folitrax 15 Tablet 10
Ipca Laboratories Pvt Ltd.
Pack of 10 Units
₹453.56
MRP ₹566.95
20% OFF
Folitrax 7.5 Tablet 10
Folitrax 7.5 Tablet 10
Ipca Laboratories Pvt Ltd.
Pack of 10 Units
₹130.6
MRP ₹163.25
20% OFF
Folitrax 20 Tablet 4
Folitrax 20 Tablet 4
Ipca Laboratories Pvt Ltd.
Pack of 4 Units
₹201.92
MRP ₹252.4
20% OFF
Folitrax 2.5 Tablet 10
Folitrax 2.5 Tablet 10
Ipca Laboratories Pvt Ltd.
Pack of 10 Units
₹44.61
MRP ₹55.76
20% OFF
Folitrax 10 Tablet 10
Folitrax 10 Tablet 10
Ipca Laboratories Pvt Ltd.
Pack of 10 Units
₹111.64
MRP ₹139.55
20% OFF
Folitrax 5 Tablet 10
Folitrax 5 Tablet 10
Ipca Laboratories Pvt Ltd.
Pack of 10 Units
₹79.22
MRP ₹99.02
20% OFF
Etret 15 Tablet 4
Etret 15 Tablet 4
Chemo Health Care Pvt Ltd
Pack of 4 Units
₹63.37
MRP ₹127
50.1% OFF

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