Megapen Capsule 10

Aristo Pharmaceuticals Pvt.ltd

Strip of 10 Units

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Old MRP ₹77

MRP ~~₹72.18~~

₹57.74

₹7.22/Units

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Composition

Ampicillin (250 Mg) + Cloxacillin (250 Mg)

Megapen Capsule 10 is used to treat bacterial infections affecting the lungs, skin, stomach, and urinary tract. It combines ampicillin and cloxacillin, which work together to stop bacterial growth by weakening the cell wall.

This capsule also helps manage infections involving the gastrointestinal tract, reproductive organs, or the bloodstream. Share your medical history with your doctor before starting the medicine, and report any reactions that occur. Continue the full course as prescribed for best improvement.

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Megapen Capsule 10 is used to treat a wide range of bacterial infections affecting the ear, nose, throat, bones, lungs, and post-surgical wounds. It is also used to treat infections such as meningitis, gonorrhoea, and gastrointestinal infections by offering broad-spectrum action against both gram-positive and gram-negative bacteria.

Swallow the whole capsule with water.
Do not crush, open, or chew the capsule.
It is generally recommended to take the capsule on an empty stomach or as directed by the doctor.
Remember to take the medicine at evenly spaced intervals, as directed by your doctor.
Always consult your doctor for precise instructions tailored to your health condition.

Megapen Capsule 10 is taken orally.

Megapen Capsule 10 may cause side effects like nausea, vomiting, diarrhea, rash, and itching. If any of these side effects persist, contact your healthcare provider.

Managing the Side Effects:

Most side effects are temporary, usually mild, and resolve upon ceasing the use of Megapen Capsule 10. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

Here are some useful guidelines for handling common side effects:

Nausea and vomiting: Try taking Megapen Capsule 10 with food to lessen these symptoms.
Skin rash and itching: Applying a cool, damp cloth to the affected area can help relieve these symptoms. Avoid scratching the affected area, as it could worsen the rash.

Megapen Capsule 10 comprises of two active ingredients:

Ampicillin (250 mg): This component belongs to a group of antibiotics known as beta-lactam antibiotics. It works by inhibiting the synthesis of bacterial cell walls. Ampicillin is active against both gram-positive and gram-negative bacteria.
Cloxacillin (250 mg): Like ampicillin, cloxacillin is also a beta-lactam antibiotic. Its primary function is to fight against penicillinase-producing staphylococci (a type of bacteria). By doing so, it prevents these bacteria from building their cell walls, thereby stopping them from multiplying.

The combination of these two components provides broad-spectrum coverage against various bacterial infections.

Pregnancy

Megapen Capsule 10 should be used during pregnancy only if clearly needed. It's a good idea to consult your doctor before taking this medicine if you are pregnant.

Breastfeeding

Ampicillin and cloxacillin, the active ingredients in Megapen Capsule 10, are passed into human milk. Caution is advised when taking this medicine if you are breastfeeding.

Alcohol

Caution is advised if you are consuming alcohol alongside Megapen Capsule 10. Please check with your doctor before consuming alcohol while on this medication.

Liver

Patients with known liver problems should exercise caution when starting Megapen Capsule 10. This medicine might influence liver function, so it's best to discuss your liver health with your doctor before starting this medication.

Kidney

Caution is advised when using Megapen Capsule 10 if you have kidney problems. Since the active ingredients in this medicine are primarily eliminated via the kidneys, patients with renal impairment may require dosage adjustments. Make sure to discuss any kidney health concerns with your doctor.

Using Machines & Driving

Megapen Capsule 10 does not directly affect your ability to drive or operate machinery. However, if you experience side effects like dizziness, it's best to avoid such activities until you know how this medicine affects you.

Allergy

Megapen Capsule 10 is contraindicated in patients who have had allergic reactions to penicillin or any other antibiotics in the past. If you have a history of allergies, inform your doctor about them before you start this medicine.

Children

Proceed with caution before giving this medicine to children under 18 years of age. Always consult a doctor before giving any medicine to a child.

Older Patients

Elderly patients could be more prone to the side effects of Megapen Capsule 10. Hence, it is recommended that older patients use this medicine under medical supervision, particularly if they are over the age of 70, have age-related kidney or liver impairment, or are on any other medication.

Drug-Drug Interactions

Megapen Capsule 10 interacts with the following medicines:

Antigout medication: Medicines like probenecid and allopurinol can lead to prolonged elevated levels of ampicillin in your blood. This may lead to a potential increase in side effects like skin rash.
Oral contraceptives: Ampicillin present in Megapen Capsule 10 may reduce the efficacy of oral contraceptives like ethinyl oestradiol and oestradiol.
Bacteriostatic antibiotics: Medicines like chloramphenicol, erythromycin, and tetracycline may interfere with the bactericidal effect of ampicillin and cloxacillin, reducing the efficacy of Megapen Capsule 10.

Drug-Food Interactions

Iron-containing foods interfere with the absorption of antibiotics in Megapen Capsule 10, making them less effective.
Calcium-fortified food items like dairy products also reduce the absorption of the antibiotics in Megapen Capsule 10.

Drug-Disease Interactions

Megapen Capsule 10 interacts with the following diseases:

Infectious mononucleosis: Ampicillin use in patients with infectious mononucleosis has been associated with the development of a rash.
Kidney disease: Megapen Capsule 10 should be used with caution in patients with kidney impairment, as they may require dose adjustments.

Daily Dose

Your recommended dose of Megapen Capsule 10 should be as your doctor prescribes. This will depend on the severity of your condition and how you respond to the medicine. Always stick to the prescribed dosage, and don't exceed it without consulting your doctor.

Over Dose

If you accidentally take more Megapen Capsule 10 than recommended, you might experience side effects like nausea, vomiting, and diarrhoea. Inform your doctor promptly.

Missed Dose

If you forget to take a dose of Megapen Capsule 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and keep to your regular dosing schedule. Never change your dosage without talking to your doctor.

Keep your Megapen Capsule 10 stored at room temperature in a cool, dry place.
Protect the capsule from heat, light, and moisture.
Always remember to keep this medicine out of reach of children.
Ensure you use the medicine before the expiration date mentioned on the pack.

Drinking plenty of water can help flush out bacteria and support overall health.
Maintaining regular meal times can help ensure you take your medicine at the right intervals.

Fact Box

Available Dosage Types	Capsule
Habit Forming	No
Ailment	Respiratory Tract Infections, Genitourinary Tract Infections, Meningitis
Drug Category	Cell Wall Synthesis Inhibitor
Therapeutic Category	Antibiotic

What is Megapen Capsule 10 used for?

Megapen Capsule 10 is used to manage a variety of bacterial infections such as respiratory tract, gastrointestinal tract, and genitourinary tract infections. It is also effective in treating skin infections and preventing infections in surgical wounds.

How does Megapen Capsule 10 work?

This medicine contains ampicillin and cloxacillin, which work together to prevent bacteria from synthesising the bacterial cell wall, resulting in the bacteria's death.

How should I take Megapen Capsule 10?

You should take Megapen Capsule 10 as advised by your doctor with water. It's important not to crush or open the capsule.

Can Megapen Capsule 10 cause allergic reactions?

Yes, Megapen Capsule 10 can cause allergic reactions in individuals with allergies to penicillin and other antibiotics. Always inform your doctor about all known allergies before taking any new medication.

Are there any precautions while taking Megapen Capsule 10?

If you have kidney or liver problems or a history of allergic reactions to penicillin, it's advisable to consult a doctor before taking this medicine.

What are the possible side effects of Megapen Capsule 10?

Common side effects include nausea, vomiting, diarrhoea, skin rash, and itching. If they persist or worsen, consult your doctor.

Can I take other medicines while using Megapen Capsule 10?

Certain medicines like oral contraceptives and antigout medications can interact with Megapen Capsule 10. It's a good practice to inform your doctor about all the medicines you are on.

Last Updated On 26 Nov. 2025 | 11:43AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 7 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

23 A, Shah Industrial Estate, Off Veera Desai Rd, Andheri West, Mumbai, Maharashtra 400053

Country of origin: INDIA

Expiry on or after: April 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (2017, Oct). Ampicillin injection label. https://www.fda.gov/media/127633/download
U.S. Food and Drug Administration. (2023, Nov 8). Ampicillin pac review 2023 - final. https://www.fda.gov/media/175001/download
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 6249, Ampicillin. https://pubchem.ncbi.nlm.nih.gov/compound/Ampicillin
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 6098, Cloxacillin. https://pubchem.ncbi.nlm.nih.gov/compound/Cloxacillin
Bornside G. H. (1968). Synergistic antibacterial activity of ampicillin-cloxacillin mixtures against Proteus morganii. Applied microbiology, 16(10), 1507–1511. https://doi.org/10.1128/am.16.10.1507-1511.1968
Sabath, L. D., Estey, V. J., & Finland, M. (1967). Independent measurement of ampicillin and cloxacillin in mixtures. Applied microbiology, 15(3), 468–470. https://doi.org/10.1128/am.15.3.468-470.1967

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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