Xigduo Xr 10mg/500mg Tablet 7

Astrazeneca Pharma India Ltd

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MRP ~~₹513~~

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Composition

Dapagliflozin (10 Mg) + Metformin (500 Mg)

Xigduo Xr 10mg/500mg Tablet 7 is used to manage type 2 diabetes in adults. It is a combination medicine which falls under the category of sodium-glucose cotransporter 2 (SGLT2) inhibitors and biguanide antihyperglycemic agents.

This medicine can also help reduce the risk of hospitalisation due to heart failure for adults with type 2 diabetes and established cardiovascular disease or multiple cardiovascular risk factors.

It is crucial that you consult your doctor for the exact dosage and timing of this medicine. You should also inform your doctor about any ongoing medication or pre-existing conditions before starting this medicine. Upon experiencing any side effects, notify your doctor at once. For optimal results, continue taking the medicine for the duration recommended by your doctor.

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Xigduo Xr 10mg/500mg Tablet 7 is used for the following:

Management of type 2 diabetes mellitus in adults when diet and exercise alone do not provide adequate control of blood sugar levels.
Reducing the risk of hospitalisation for heart failure in adults with type 2 diabetes and established heart disease or multiple risk factors for heart disease.

Here are some instructions to follow while taking Xigduo Xr 10mg/500mg Tablet 7:

Take the medicine as prescribed by your doctor.
Swallow the tablet whole with a glass of water. Do not crush, cut, or chew it.
If you have any questions about how to take this medicine, consult your doctor.

Xigduo Xr 10mg/500mg Tablet 7 is taken orally.

Using Xigduo Xr 10mg/500mg Tablet 7 may result in a few common side effects:

Dehydration
Genital mycotic infections
Urinary tract infections
Low blood pressure

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Xigduo Xr 10mg/500mg Tablet 7. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Genital mycotic infections: Maintain good genital hygiene to lessen this effect.
Urinary tract infections: Stay hydrated to help manage this side effect.

Xigduo Xr 10mg/500mg Tablet 7 consists of two active ingredients:

Dapagliflozin (10 mg): As an SGLT2 inhibitor, dapagliflozin minimises kidney glucose reabsorption and lowers the renal threshold for glucose. This action increases glucose excretion through urine, thereby decreasing blood glucose levels.
Metformin (500 mg): Metformin reduces liver glucose production and intestinal absorption of glucose while improving insulin sensitivity by boosting peripheral glucose uptake and utilisation. These actions collectively help lower blood glucose levels.

Pregnancy

Consult your doctor before taking Xigduo Xr 10mg/500mg Tablet 7 if you are pregnant. It is essential to discuss the potential risks and benefits with your doctor.

Breastfeeding

Xigduo Xr 10mg/500mg Tablet 7 is not recommended for breastfeeding women. Consult your doctor to understand the possible risks and benefits.

Alcohol

Caution is advised when consuming alcohol while taking this medicine. Alcohol may interact with Xigduo Xr 10mg/500mg Tablet 7, potentially leading to an increased risk of lactic acidosis and hypoglycemia.

Liver

If you have liver health issues, it is important to discuss them with your doctor before starting Xigduo Xr 10mg/500mg Tablet 7. This medicine may impact liver function, so caution is recommended.

Kidney

Xigduo Xr 10mg/500mg Tablet 7 is not suitable if you have severe kidney impairment. For those with moderate renal impairment, it's advisable to consult your doctor before starting this medicine.

Using Machines & Driving

No specific precautions are required while driving or operating machinery after taking Xigduo Xr 10mg/500mg Tablet 7. However, if you experience side effects like dizziness, avoid such activities until you feel well again.

Allergy

Avoid using this medicine if you're allergic to dapagliflozin, metformin, or any other ingredient in Xigduo Xr 10mg/500mg Tablet 7. If unsure, consult your doctor.

Children

This medicine is not recommended for use in children under 18 years of age. Always consult a doctor before giving any medicine to a child.

Older Patients

Older patients should take Xigduo Xr 10mg/500mg Tablet 7 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age due to potential liver and kidney issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Xigduo Xr 10mg/500mg Tablet 7 interacts with the following medicines:

Diuretics: This medication may interact with diuretics like furosemide or hydrochlorothiazide, potentially increasing the risk of hypotension and electrolyte imbalances.
Insulin and insulin secretagogues: Concomitant use of insulin or insulin secretagogues such as glipizide with Xigduo Xr 10mg/500mg Tablet 7 may increase the risk of hypoglycemia.
Carbonic anhydrase inhibitors: Medicines like acetazolamide may interact with this medication, possibly increasing the risk of lactic acidosis.
Cationic medicines: Medications such as amiloride and digoxin may reduce metformin elimination, leading to increased metformin levels in your body.

Drug-Food Interactions

There are no specific food interactions known with Xigduo Xr 10mg/500mg Tablet 7.

Drug-Disease Interactions

Xigduo Xr 10mg/500mg Tablet 7 interacts with the following diseases:

Renal impairment: Patients with renal impairment should exercise caution as this medicine could exacerbate their condition.
Heart failure: This medication could impact heart function, making it crucial to monitor heart health closely when on this medication.
Pancreatitis: Patients with a history of pancreatitis might experience worsening of their condition due to this medicine.

Daily Dose

You should take your daily dose of Xigduo Xr 10mg/500mg Tablet 7 as directed by your doctor. The dosage might be adjusted depending on factors like the severity of your condition and how you respond to the medicine. Always stick to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

Overdosing on Xigduo Xr 10mg/500mg Tablet 7 may lead to side effects like lightheadedness or dizziness. If you take more than the prescribed dose and experience such symptoms, consult your doctor.

Missed Dose

If you forget to take your Xigduo Xr 10mg/500mg Tablet 7, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never adjust your dosage without asking your doctor first.

Store Xigduo Xr 10mg/500mg Tablet 7 at room temperature, ideally between 20°C and 25°C.
Keep it in its original packaging to protect it from light and moisture.
Place the medicine in a secure location, away from children's reach.

Maintain a balanced diet low in sugar, as Xigduo Xr 10mg/500mg Tablet 7 is used to manage type 2 diabetes. This includes limiting the intake of sweets, fizzy drinks, and food high in carbohydrates.
Regular exercise is crucial. Incorporate physical activities like brisk walking or cycling into your daily routine to help lower blood glucose levels and boost the effectiveness of Xigduo Xr 10mg/500mg Tablet 7.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 diabetes, Cardiovascular disease
Drug Category	SGLT2 inhibitor, Biguanide
Therapeutic Category	Antidiabetic

Is Xigduo Xr 10mg/500mg Tablet 7 meant for managing type 1 diabetes?

No, Xigduo Xr 10mg/500mg Tablet 7 is specifically designed to manage type 2 diabetes in adults.

Do I need to check my kidney function while using Xigduo Xr 10mg/500mg Tablet 7?

Yes, you should check your kidney function before starting and during treatment, as dose adjustments might be needed if you have moderate kidney impairment.

Can I crush or chew Xigduo Xr 10mg/500mg Tablet 7?

No, the tablet should be swallowed whole without crushing or chewing it to ensure proper release of the active ingredients.

What should I do if I suspect a urinary infection while taking Xigduo Xr 10mg/500mg Tablet 7?

If you have symptoms like a burning sensation during urination or cloudy urine, please consult your doctor promptly for evaluation and appropriate management.

Can I use Xigduo Xr 10mg/500mg Tablet 7 during pregnancy?

Caution is advised while using this medicine during pregnancy. Inform your doctor about your pregnancy before starting the medicine.

Am I at risk of vitamin B12 deficiency while taking Xigduo Xr 10mg/500mg Tablet 7?

Yes, regular monitoring of vitamin B12 levels is recommended, especially if you have risk factors for deficiency.

Can I use other diabetes medications while on Xigduo Xr 10mg/500mg Tablet 7?

Yes, it can be used alone or with other antidiabetic medicines; however, always consult your doctor about any potential medicine interactions.

Last Updated On 13 May. 2025 | 11:19AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Block N1, 12th Floor, Manyata Embassy Business Park, Rachenahalli, Outer Ring Road Bangalore India 560045

Country of origin: USA

Expiry on or after: October 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Dapagliflozin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB06292
Dapagliflozin: MedlinePlus Drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a614015.html
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 9887712, Dapagliflozin. Retrieved June 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Metformin: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a696005.html
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 4091, Metformin. Retrieved June 18, 2024 from https://pubchem.ncbi.nlm.nih.gov/compound/Metformin.

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U85320MH2019PTC320566

Telephone:09240250346

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Email: grievance-officer@truemeds.in

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