CompositionNatrise Tablet is used to treat low sodium in the blood (hyponatraemia) caused by the body holding on to too much water, such as in heart failure or a condition called SIADH. It is a single-ingredient medicine containing tolvaptan, which belongs to a class of medicines called vasopressin receptor antagonists.
This medicine helps the kidneys pass out extra water while keeping sodium, so blood sodium levels rise. Treatment is started in hospital so that sodium can be checked often, because raising it too quickly can cause serious brain damage. Take it once a day as prescribed, and drink water whenever you feel thirsty unless your doctor advises otherwise; do not restrict fluids in the first day unless told to.
Keep water within easy reach, and follow any other fluid and diet advice from your doctor. Avoid grapefruit and grapefruit juice.
This medicine can cause serious liver injury and is usually given for no longer than 30 days, with liver blood tests. Do not take it if you have liver disease, cannot sense or respond to thirst, have very low blood volume, or cannot pass urine. Before starting, tell your doctor about all other medicines you take, especially certain antifungals, antibiotics and medicines that raise potassium. Do not take it if you are pregnant or breastfeeding. Seek medical help straight away for confusion, difficulty speaking or swallowing, weakness, drowsiness, or yellowing of the skin or eyes, dark urine or stomach pain. Do not stop taking this medicine unless your doctor advises you to do so.
