Istavel D 10/100 Tablet 15

Sun Pharma Laboratories Ltd.

Strip of 15 Units

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Old MRP ₹321

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Composition

Dapagliflozin (10 Mg) + Sitagliptin (100 Mg)

Istavel D 10/100 Tablet is used to manage type 2 diabetes by controlling blood sugar levels. This combination medicine helps maintain stable glucose levels, supports glycemic management, and reduces the risk of diabetes-related complications. Regular use promotes overall metabolic health and long-term well-being in diabetic adults. It belongs to the category of anti-diabetic medications.

Apart from regulating blood glucose, this medication also minimises the risk of severe complications related to diabetes, such as kidney damage, vision problems, nerve issues, and limb loss.

The correct dosage and frequency for taking this medicine should be determined by your doctor. Before starting the medicine, it's important to inform your doctor about any pre-existing conditions or ongoing medications. If you experience any side effects while on this medicine, report them to your doctor right away. The medication should be continued for the duration prescribed by your doctor for the best results.

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Istavel D 10 100 Tablet is used to treat type 2 diabetes in adults, helping lower blood sugar levels and improve insulin use. When combined with diet and exercise, it helps control glucose levels, especially when metformin alone isn’t enough, and reduces the risk of complications.

Here are some key instructions to follow while taking Istavel D 10/100 Tablet:

Swallow the tablet whole, without crushing or chewing it.
You can take this medicine with or without food.
Ensure you take this medicine at a fixed time daily for consistent results.
Consult your doctor before stopping the medication.

Istavel D 10/100 Tablet is taken orally.

Upon taking Istavel D 10/100 Tablet, you may experience some side effects, like:

Urinary tract infections (UTIs)
Nasal congestion
Sore throat
Headache

Managing the Side Effects:

Most side effects are temporary and generally mild and resolve upon discontinuing the use of Istavel D 10/100 Tablet. However, if you experience any serious side effects or worsening of any symptoms, consult your doctor.

Here are a couple of tips for managing side effects:

Urinary tract infections: Drinking plenty of fluids can help flush bacteria out of your urinary system and reduce the risk of UTIs.
Nasal congestion: If nasal congestion becomes troublesome, try taking this medicine at bedtime to lessen discomfort during the day.

Istavel D 10/100 Tablet contains two active ingredients:

Dapagliflozin (10 mg): This component falls under the category of SGLT2 inhibitors. Its function is to enhance the excretion of glucose through urine, consequently lowering the levels of blood sugar.
Sitagliptin (100 mg): Sitagliptin is a DPP-4 inhibitor, and it operates by increasing insulin levels while reducing glucagon, a hormone that elevates blood glucose levels. This leads to decreased glucose production by the liver.

Together, these actions result in improved control over blood sugar in patients with type 2 diabetes.

Pregnancy

If you are pregnant or planning to conceive, it is advised to exercise caution while taking Istavel D 10/100 Tablet. Make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Istavel D 10/100 Tablet is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Avoid excessive alcohol consumption while on this medication, as it can increase the risk of certain side effects. It's best to consult your doctor for specific advice.

Liver

If you have liver problems, caution is recommended when taking Istavel D 10/100 Tablet. Discuss any liver-related concerns with your doctor before starting this medicine.

Kidney

Caution is advised if you have a history of kidney problems. Consult your doctor before taking Istavel D 10/100 Tablet.

Using Machines & Driving

This medicine does not generally affect your ability to drive or operate machinery. However, if you feel dizzy or tired after taking it, avoid driving or using machines until you feel well again.

Allergy

Do not take Istavel D 10/100 Tablet if you are allergic to dapagliflozin, sitagliptin, or any other ingredients. Always inform your doctor about known allergies.

Children

Istavel D 10/100 Tablet is not recommended for use in children below 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Istavel D 10/100 Tablet under medical supervision, as they may be more susceptible to its side effects. Caution is advised if patients are over 70 years of age.

Drug-Drug Interactions

Istavel D 10/100 Tablet interacts with the following medicines:

Diuretics: Medicines like amiloride and furosemide may interact with Istavel D 10/100 Tablet, increasing the diuretic effects on your body.
Corticosteroids: Medications such as prednisolone and hydrocortisone could interact with Istavel D 10/100 Tablet, potentially reducing its ability to control blood sugar levels.
Estrogens: Medicines like estrone and estradiol may interfere with this medicine, potentially decreasing the effectiveness of Istavel D 10/100 Tablet.
Anti-diabetic medicines: Other anti-diabetic medicines, such as glimepiride and chlorpropamide, can affect the action of Istavel D 10/100 Tablet, potentially impacting blood sugar control.

Drug-Food Interactions

There are no significant food interactions with Istavel D 10/100 Tablet.

Drug-Disease Interactions

Istavel D 10/100 Tablet interacts with the following diseases:

Kidney problems: If you have kidney issues, this tablet might not work as effectively for managing your diabetes.
Liver disease: A history of liver disease could potentially affect how Istavel D 10/100 Tablet controls blood sugar levels. Consult your doctor for specific advice.

Daily Dose

The daily dose of Istavel D 10/100 Tablet should be taken as instructed by your doctor. The dosage is based on the intensity of your condition and how you respond to the medication. It's crucial to stick to the prescribed dosage and never increase the dosage without your doctor's advice.

Over Dose

An overdose of Istavel D 10/100 Tablet may lead to symptoms like headaches or respiratory tract infections. If you suspect an overdose, it's important to get in touch with your doctor for advice and further instructions.

Missed Dose

If you miss a dose of Istavel D 10/100 Tablet, take it as soon as you can. However, if it's almost time for the next dose, forget about the missed one and carry on with your usual dosing schedule. Do not double up on doses before consulting your doctor.

Store Istavel D 10/100 Tablet at a temperature below 30°C, away from direct sunlight.
Keep the tablet in a dry place, free from moisture.
Always keep this medicine out of the reach of children.
Ensure you use it before the expiration date printed on the pack.

Follow a balanced diet with a controlled sugar intake. This can help manage your blood sugar levels, complementing the action of Istavel D 10/100 Tablet.
Engage in regular physical activity or exercise, as it helps improve insulin sensitivity and lowers blood glucose levels. Always consult your doctor before starting any new exercise routine.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	SGLT2 Inhibitor, DPP-4 Inhibitor
Therapeutic Category	Antidiabetic

What is Istavel D 10/100 Tablet used for?

Istavel D 10/100 Tablet is a combination medicine used to help manage blood sugar levels in adults with type 2 diabetes mellitus. When used with diet and exercise, it improves blood sugar control by helping the body utilize insulin effectively, lowering blood sugar levels.

How does Istavel D 10/100 Tablet work?

This medicine contains dapagliflozin and sitagliptin. Dapagliflozin reduces blood sugar by increasing glucose excretion through urine, and sitagliptin raises insulin levels while reducing glucagon.

How should I take Istavel D 10/100 Tablet?

You should take the tablet whole, without chewing, crushing, or breaking it. It can be taken with or without food, preferably at the same time each day.

What if I miss a dose of Istavel D 10/100 Tablet?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue your regular schedule.

What are the side effects of Istavel D 10/100 Tablet?

Common side effects include urinary tract infections, nasal congestion, sore throat, upper respiratory tract infections, headache, and vaginal yeast infections in females.

Are there any precautions I should take when using Istavel D 10/100 Tablet?

Inform your doctor about any pre-existing health conditions such as kidney problems or liver disease. Avoid excessive alcohol consumption while taking this medication.

Can Istavel D 10/100 Tablet interact with other medicines?

Yes, it may interact with certain medicines, such as diuretics and corticosteroids. Always discuss your current medications with your doctor before starting it.

Last Updated On 22 Sep. 2025 | 10:47AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Osama Ahmed

Medical Content Writer | 3 years

Bachelor of Dental Surgery

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (2020, May). Farxiga (dapagliflozin) tablets label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
U.S. Food and Drug Administration. (2012). Januvia (sitagliptin) tablets label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s019lbl.pdf
U.S. Food and Drug Administration. (2020. May 5). FDA approves new treatment for a type of heart failure. https://www.fda.gov/news-events/press-announcements/fda-approves-new-treatment-type-heart-failure
Jabbour, S. A., Hardy, E., Sugg, J., Parikh, S., & Study 10 Group. (2014). Dapagliflozin is effective as add-on therapy to sitagliptin with or without metformin: a 24-week, multicenter, randomized, double-blind, placebo-controlled study. Diabetes care, 37(3), 740–750. https://doi.org/10.2337/dc13-0467
AHFS Patient Medication Information [Internet]. (2024, Feb 15). Dapagliflozin. MedLinePlus. https://medlineplus.gov/druginfo/meds/a614015.html
National Health Service. (n.d.). Sitagliptin. https://www.nhs.uk/medicines/sitagliptin
National Health Service. (n.d.). Dapagliflozin. https://www.nhs.uk/medicines/dapagliflozin

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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