Daplo S 10/100 Tablet 10

Dr. Reddys Laboratories Ltd

Strip of 10 Units

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Old MRP ₹239.5

MRP ~~₹224.53~~

₹179.62

₹22.45/Units

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Composition

Dapagliflozin (10 Mg) + Sitagliptin (100 Mg)

Daplo S 10/100 Tablet 10 is used in managing type 2 diabetes mellitus in adults whose blood sugar levels are not adequately controlled through diet and exercise alone. It combines dapagliflozin and sitagliptin, working through different mechanisms to effectively lower blood glucose levels.

This tablet may also be taken alongside other diabetes medicines such as metformin, sulphonylureas, or insulin for comprehensive glycaemic control. Follow your doctor’s dosage instructions, inform them about any health conditions or medications, and report any side effects. Continue the medicine for the full prescribed duration for best results.

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Daplo S 10/100 Tablet 10 is used to manage type 2 diabetes by improving overall blood sugar control. With dapagliflozin to increase glucose removal through urine and sitagliptin to enhance insulin release and reduce liver glucose production, it provides multi-level control. It works best when paired with diet adjustments, weight management, and regular physical activity.

Daplo S 10/100 Tablet 10 should be swallowed whole with a glass of water.
Do not crush or chew the tablet.
The medicine can be taken with or without food, but try to take it the same way every time.
It's crucial not to stop taking this medicine without consulting your doctor.

Daplo S 10/100 Tablet 10 is taken orally.

Daplo S 10/100 Tablet 10 may cause side effects such as common cold, headache, back pain, joint pain, diarrhoea, and nausea. Consult your doctor if these side effects do not improve.

Managing the Side Effects:

Most side effects are temporary, usually harmless, and resolve upon discontinuing the use of Daplo S 10/100 Tablet 10. However, if you experience serious side effects or worsening of any symptoms, please consult your doctor.

Here are some helpful tips for handling common side effects:

Diarrhoea: Try taking Daplo S 10/100 Tablet 10 with food to lessen this effect.
Nausea: If you feel nauseated after taking this medicine, consider taking it after eating a meal to help reduce this feeling.

Daplo S 10/100 Tablet 10 has two active components that work together to control blood glucose levels:

Dapagliflozin (10 mg): This SGLT2 inhibitor blocks the reabsorption of glucose in your kidneys. This leads to the excretion of excess glucose through urine, reducing the amount of sugar in your bloodstream.
Sitagliptin (100 mg): As a DPP-4 inhibitor, sitagliptin inhibits certain hormones, stimulating the pancreas to produce more insulin when blood glucose levels are high. It also decreases the production of glucagon by the pancreas, reducing the amount of glucose produced by the liver.

Pregnancy

One of the active ingredients in Daplo S 10/100 Tablet 10, dapagliflozin, is contraindicated during the second and third trimesters of pregnancy. If you are pregnant, proceed with caution and consult your doctor before starting this medicine.

Breastfeeding

As this medication may pass into breast milk and cause major adverse effects in breastfed infants, it is not advised to use it while breastfeeding. Consult your doctor before starting Daplo S 10/100 Tablet 10.

Alcohol

Alcohol can interfere with the effectiveness of Daplo S 10/100 Tablet 10 and also affect blood sugar levels. It's best to consult your doctor about safe alcohol consumption while on this medication.

Liver

Daplo S 10/100 Tablet 10 does not require adjustments in dosage for patients with mild liver impairment. However, if you have severe liver disease, caution is advised. Discuss your liver health concerns with your doctor before starting this medicine.

Kidney

Daplo S 10/100 Tablet 10 is not recommended for those with severe kidney impairment or end-stage kidney disease. If you have a history of kidney problems, it would be prudent to consult your doctor before taking this medication.

Using Machines & Driving

Daplo S 10/100 Tablet 10 doesn't generally affect your ability to drive or operate machinery. However, if you feel dizzy or unwell after taking it, it might be safer to avoid such activities until you feel better.

Allergy

If you are allergic to dapagliflozin, sitagliptin, or any other ingredients in this medicine, do not take it. If you've experienced allergic reactions to similar medicines in the past, discuss these with your doctor before starting Daplo S 10/100 Tablet 10.

Children

Daplo S 10/100 Tablet 10 should not be given to children under 18 years of age. Always consult a doctor before giving any adult medicine to a child.

Older Patients

Older patients may be more susceptible to the side effects of Daplo S 10/100 Tablet 10, especially if they have existing liver or kidney issues or are on other medications. It is advised to consult your doctor about these potential risks before starting this medication.

Drug-Drug Interactions

Daplo S 10/100 Tablet 10 interacts with the following medicines:

Diuretics: Medicines like furosemide or hydrochlorothiazide may increase the risk of dehydration and low blood pressure when taken with Daplo S 10/100 Tablet 10.
Insulin or insulin secretagogues: Medicines such as insulin glargine, glipizide, or glyburide can increase the risk of low blood sugar when used with Daplo S 10/100 Tablet 10; hence, a lower dose may be needed.
Oral contraceptives: Medicines like levonorgestrel, norethindrone, and oestradiol can affect blood glucose levels, possibly reducing the efficacy of Daplo S 10/100 Tablet 10.
Antibiotics: Antibiotics like gatifloxacin and ciprofloxacin may affect blood sugar levels, affecting the efficacy of Daplo S 10/100 Tablet 10 and increasing the risk of high or low blood sugar.

Drug-Food Interactions

There are no specific food interactions with Daplo S 10/100 Tablet 10.

Drug-Disease Interactions

Daplo S 10/100 Tablet 10 interacts with the following diseases:

Kidney disease: Individuals with severe kidney impairment, end-stage renal disease, or dialysis should avoid the use of Daplo S 10/100 Tablet 10, as it can worsen their condition.
Liver disease: Individuals with severe liver disease should proceed with caution before taking this tablet.
Diabetic ketoacidosis: This condition also contraindicates the use of Daplo S 10/100 Tablet 10.
Pancreatitis or gallstones: Patients with these conditions should use Daplo S 10/100 Tablet 10 with caution.

Daily Dose

The daily dose of Daplo S 10/100 Tablet 10 should be taken as guided by your doctor. The dosage may vary depending on factors such as the seriousness of your condition and how you respond to the medicine. Adhere to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

If you accidentally take more Daplo S 10/100 Tablet 10 than recommended, you might experience symptoms like headaches, back pain, or diarrhoea. In such cases, inform your doctor immediately.

Missed Dose

If you forget to take a dose of Daplo S 10/100 Tablet 10, take it as soon as you remember. If it's nearly time for your next dose, skip the one you missed and continue with your regular schedule. Never alter your dosage without consulting your doctor.

Store Daplo S 10/100 Tablet 10 at room temperature, ideally below 30°C.
The product should be kept in its original packaging to protect it from light and moisture.
Take the tablet out of its original packaging only when it is time to take the medicine.
Keep Daplo S 10/100 Tablet 10 out of reach of children to prevent accidental ingestion.
Always use the medicine before the expiration date indicated on the package.

Regular physical activity is recommended, as it helps your body use insulin more efficiently. This can help manage your blood sugar levels if you have type 2 diabetes.
Aim to have a balanced diet with controlled portions of carbohydrates. This can help to avoid sudden spikes in your blood sugar levels.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes
Drug Category	SGLT2 Inhibitor, DPP-4 Inhibitor
Therapeutic Category	Antidiabetic

What is Daplo S 10/100 Tablet 10 used for?

Daplo S 10/100 Tablet 10 is primarily used to manage type 2 diabetes in adults, improving blood sugar levels with a healthy diet and regular exercise.

Can Daplo S 10/100 Tablet 10 be used as a weight loss medicine?

No, while some patients may experience weight loss due to the glucose-excreting effect of dapagliflozin, Daplo S 10/100 Tablet 10 isn't indicated for weight loss.

How does Daplo S 10/100 Tablet 10 work?

Daplo S 10/100 Tablet 10 combines two active ingredients, dapagliflozin and sitagliptin, which work together to lower blood glucose levels through separate mechanisms in the body.

What should I do if I miss a dose of Daplo S 10/100 Tablet 10?

If you miss a dose, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue your regular schedule. Don't double up on doses to compensate for the missed one.

Can Daplo S 10/100 Tablet 10 be taken alongside other diabetes medicines?

Yes, it can be combined with other diabetes medicines, such as metformin or insulin, but always consult your doctor before taking any medicines together.

What are the side effects of Daplo S 10/100 Tablet 10?

Common side effects include cold, headaches, back pain, joint pain, and nausea, among others. Severe side effects are rare but possible; in such cases, seek immediate medical attention.

Is Daplo S 10/100 Tablet 10 safe during pregnancy or breastfeeding?

Daplo S 10/100 Tablet 10 should be used by pregnant and nursing women only if medically prescribed. Always consult your doctor for advice.

Last Updated On 17 Dec. 2025 | 5:28AM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 9 years

Doctor of Medicine

Reviewed by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 7 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

Bigshare Services Pvt. Ltd. 306, Right Wing, 3rd Floor Amrutha Ville, Opp.Yash Hyderabad - 500082 Telangana

Country of origin: INDIA

Expiry on or after: April 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (2023, May). Farxiga (dapagliflozin) label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2023/202293s026lbl.pdf
U.S. Food and Drug Administration. (2018, Feb). Januvia (sitagliptin) label. https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/021995s042lbl.pdf
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 4369359, Sitagliptin. https://pubchem.ncbi.nlm.nih.gov/compound/Sitagliptin
National Center for Biotechnology Information (2024). PubChem Compound Summary for CID 9887712, Dapagliflozin. https://pubchem.ncbi.nlm.nih.gov/compound/Dapagliflozin
DrugBank Online. (2024, Aug). Dapagliflozin. https://go.drugbank.com/drugs/DB06292
DrugBank Online. (2024, Aug). Sitagliptin. https://go.drugbank.com/drugs/DB01261
Kang, S. J., & Kim, J. E. (2023). Development of Clinically Optimized Sitagliptin and Dapagliflozin Complex Tablets: Pre-Formulation, Formulation, and Human Bioequivalence Studies. Pharmaceutics, 15(4), 1246. https://doi.org/10.3390/pharmaceutics15041246

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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