Lupisit M 500 Tablet 10

Lupin Ltd

Strip of 10 Units

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MRP ~~₹145.2~~

₹116.16

₹14.52/Units

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Composition

Metformin (500 Mg) + Sitagliptin (50 Mg)

Lupisit-M 500 Tablet is used to control high blood sugar levels in patients with type 2 diabetes mellitus, alongside a healthy diet and regular exercise. It combines metformin (which reduces glucose production in the liver) and sitagliptin (which increases insulin release and decreases glucose production). This combination medicine belongs to the class of antidiabetic agents, specifically biguanides and dipeptidyl peptidase4 (DPP4) inhibitors.

In addition to its main use, it also aids in improving blood sugar control in adults with type 2 diabetes. It is particularly useful in reducing both the base level and postmeal levels of glucose in the blood.

Before starting this medicine, it's important to consult your doctor about any existing health conditions or ongoing medications. If you experience any side effects, let your doctor know immediately. To achieve the best results, ensure you continue taking this medicine for the entire duration prescribed by your doctor.

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Lupisit-M 500 Tablet is used for the following:

Improving blood sugar control in adults with type 2 diabetes
Lowering both basal and postprandial plasma glucose
Reducing hepatic glucose production
Decreasing intestinal absorption of glucose
Improving insulin sensitivity in the body
Regulating levels of insulin produced after eating
Decreasing the amount of sugar made by the liver.

Here's how to take Lupisit-M 500 Tablet:

Swallow the tablet whole with a glass of water.
Make sure not to crush, chew or split the tablet.
Always take this medicine with your meals.
Do not exceed the dose prescribed by your doctor.
If you're unsure about anything, consult your doctor for clarification.

Lupisit-M 500 Tablet is taken orally.

Lupisit-M 500 Tablet may have the following common side effects:

Upper respiratory tract infection: This refers to an infection that can cause symptoms such as a cough or a sore throat.
Nasopharyngitis: This is an inflammation of the upper part of the throat behind the nose. It may lead to a running or blocked nose, a sore throat, and sneezing.
Diarrhoea
Headache
Nausea
Vomiting
Abdominal pain
Flatulence
Dyspepsia: Also known as indigestion, it can cause discomfort in your upper abdomen, including feelings of fullness and bloating.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lupisit-M 500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some guidelines for managing common side effects:

Diarrhoea: Try taking Lupisit-M 500 Tablet with food to help reduce this effect.
Dyspepsia: If you have indigestion, consider taking this medicine after meals to lessen this effect.

Lupisit-M 500 Tablet comprises two active ingredients:

Metformin (500 mg): This component works by reducing the production of glucose in your liver and decreasing the absorption of glucose in your intestines. Furthermore, it enhances insulin sensitivity, which encourages more effective glucose uptake and use by your body's cells. It does not stimulate insulin secretion, so it rarely causes low blood sugar when used alone.
Sitagliptin (50 mg): As a DPP4 inhibitor, sitagliptin slows down the breakdown of incretin hormones. These hormones help to regulate blood sugar levels by increasing insulin release from your pancreas and decreasing glucagon secretion from your pancreas after meals.

Pregnancy

Caution is advised while taking Lupisit-M 500 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

It's advisable not to use Lupisit-M 500 Tablet when breastfeeding. Always consult your doctor for further guidance.

Alcohol

Alcohol can affect blood sugar levels and increase the risk of lactic acidosis, a rare but serious side effect of Metformin. Therefore, you should limit your alcohol intake while taking Lupisit-M 500 Tablet.

Liver

Patients with liver conditions should avoid using Lupisit-M 500 Tablet as they are at a higher risk for lactic acidosis. Discuss with your doctor about any liver problems before starting this medicine.

Kidney

Lupisit-M 500 Tablet is not recommended for patients with severe kidney impairment. Always share your complete health history with your doctor before starting any new medicine.

Using Machines & Driving

Lupisit-M 500 Tablet does not usually interfere with the ability to drive or operate machinery. However, if you experience side effects like dizziness or fatigue, avoid these activities until you feel better.

Allergy

If you know you're allergic to Metformin, Sitagliptin, or any other ingredients in Lupisit-M 500 Tablet, avoid using this medicine. Always inform your doctor about any allergies or adverse reactions to medicines.

Children

It's always best to consult a doctor before giving this medicine to children.

Older Patients

Older patients should take Lupisit-M 500 Tablet under medical supervision as they may be more susceptible to its side effects. If you are an older patient, your doctor will guide you based on your health status before starting this medicine.

Drug-Drug Interactions

Lupisit-M 500 Tablet interacts with the following medicines:

Diuretics: Medicines like furosemide and hydrochlorothiazide may increase the risk of lactic acidosis when taken with Lupisit-M 500 Tablet due to their effect on kidney function.
Corticosteroids: Medicines such as prednisolone can raise blood sugar levels, potentially reducing the effectiveness of Lupisit-M 500 Tablet in managing diabetes.
Thyroid products: Medications like levothyroxine can cause hyperglycaemia, which could decrease the effectiveness of Lupisit-M 500 Tablet.
Oral contraceptives: Birth control pills like ethinyl estradiol and levonorgestrel may increase blood sugar levels, potentially reducing the efficacy of Lupisit-M 500 Tablet.

Drug-Food Interactions

Lupisit-M 500 Tablet should be taken with meals to reduce the gastrointestinal side effects. Specific food interactions have not been reported.

Drug-Disease Interactions

Lupisit-M 500 Tablet interacts with the following diseases:

Kidney Disease: Patients with severe renal impairment should not use Lupisit-M 500 Tablet due to the increased risk of lactic acidosis.
Liver Disease: The medication should be avoided in patients with liver disease as they are at higher risk for lactic acidosis.
Heart Failure: Patients at risk for heart failure should be carefully monitored while taking this medication due to a potential association between DPP4 inhibitor treatment and heart failure.

Daily Dose

The dosage of Lupisit-M 500 Tablet you take daily should be as prescribed by your doctor. This can vary based on individual factors like the severity of your condition and how you respond to the medicine. Always follow your doctor's instructions and never exceed the prescribed dosage without consulting them.

Over Dose

An overdose of Lupisit-M 500 Tablet may lead to common side effects like nausea, headaches, and diarrhoea. In case you experience these symptoms persistently after taking more than the recommended dose, inform your doctor.

Missed Dose

If you forget to take a dose of Lupisit-M 500 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Avoid increasing your dosage without consulting your doctor.

Store Lupisit-M 500 Tablet at a temperature below 30°C.
Keep it away from excessive light and moisture.
Ensure the medicine is kept out of reach of children.
Always check the expiry date on the pack before use.

Maintain a balanced diet low in sugar and saturated fats to help manage type 2 diabetes better.
Regular physical exercise, like brisk walking or cycling, can help improve insulin sensitivity and keep your blood sugar levels in control.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus
Drug Category	DPP 4 Inhibitor, Biguanide
Therapeutic Category	Antidiabetic

What is Lupisit-M 500 Tablet used for?

Lupisit-M 500 Tablet is used to manage type 2 diabetes in adults, alongside diet and exercise.

How does Lupisit-M 500 Tablet work?

It contains metformin that reduces the liver's sugar production and sitagliptin that controls postmeal insulin levels, thereby managing blood sugar.

Can I use Lupisit-M 500 Tablet for type 1 diabetes?

No, this medicine is not suitable for managing type 1 diabetes or diabetic ketoacidosis.

What should I do if I miss a dose of Lupisit-M 500 Tablet?

Take the missed dose as soon as you remember, unless it's nearly time for your next dose. Do not take double the dose.

How long does it take to see results with Lupisit-M 500 Tablet?

While some people may see improvements within two weeks, optimal results generally appear after about three months of continuous usage.

Is Lupisit-M 500 Tablet safe during pregnancy or while breastfeeding?

Caution is advised while taking Lupisit-M 500 Tablet if you are pregnant or breastfeeding. It is best to consult your doctor before taking this medicine.

Can I break or chew the Lupisit-M 500 Tablet?

No, the tablet should be swallowed whole with water; do not break, chew or crush it.

Last Updated On 13 May. 2025 | 11:01AM (IST)

Certified Content

Written by

Dr Vatsalya D Ghanekar

Medical Content Writer | 6 years

MD Ayurveda

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

Expiry on or after: November 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Merck Sharp & Dohme Corp. (2007). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022044s042lbl.pdf
Merck Sharp & Dohme Corp. (2006). Highlights of prescribing information [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s019lbl.pdf
Sitagliptin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01261
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

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