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CompositionLupisit-M 500 Tablet is used to control blood sugar levels in type 2 diabetes. It combines metformin and sitagliptin to improve insulin response and regulate glucose levels. Follow your doctor’s dosage instructions and inform them about any other conditions or medications. If you experience any side effects, notify your doctor right away.
Lupisit-M 500 Tablet helps improve blood sugar control in adults with type 2 diabetes. It lowers both basal and postprandial blood glucose levels by reducing glucose production in the liver and improving insulin sensitivity. The tablet also regulates insulin production after meals, ensuring effective blood sugar management.
Here's how to take Lupisit-M 500 Tablet:
Swallow the tablet whole with a glass of water.
Make sure not to crush, chew or split the tablet.
Always take this medicine with your meals.
Do not exceed the dose prescribed by your doctor.
If you're unsure about anything, consult your doctor for clarification.
Lupisit-M 500 Tablet is taken orally.
Lupisit-M 500 Tablet may cause upper respiratory tract infection, nasopharyngitis, diarrhea, headache, nausea, vomiting, abdominal pain, flatulence, and dyspepsia (indigestion).
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Lupisit-M 500 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some guidelines for managing common side effects:
Diarrhoea: Try taking Lupisit-M 500 Tablet with food to help reduce this effect.
Dyspepsia: If you have indigestion, consider taking this medicine after meals to lessen this effect.
Lupisit-M 500 Tablet comprises two active ingredients:
Metformin (500 mg): This component works by reducing the production of glucose in your liver and decreasing the absorption of glucose in your intestines. Furthermore, it enhances insulin sensitivity, which encourages more effective glucose uptake and use by your body's cells. It does not stimulate insulin secretion, so it rarely causes low blood sugar when used alone.
Sitagliptin (50 mg): As a DPP4 inhibitor, sitagliptin slows down the breakdown of incretin hormones. These hormones help to regulate blood sugar levels by increasing insulin release from your pancreas and decreasing glucagon secretion from your pancreas after meals.
Caution is advised while taking Lupisit-M 500 Tablet if you are pregnant. It is best to consult your doctor before taking this medicine.
It's advisable not to use Lupisit-M 500 Tablet when breastfeeding. Always consult your doctor for further guidance.
Alcohol can affect blood sugar levels and increase the risk of lactic acidosis, a rare but serious side effect of Metformin. Therefore, you should limit your alcohol intake while taking Lupisit-M 500 Tablet.
Patients with liver conditions should avoid using Lupisit-M 500 Tablet as they are at a higher risk for lactic acidosis. Discuss with your doctor about any liver problems before starting this medicine.
Lupisit-M 500 Tablet is not recommended for patients with severe kidney impairment. Always share your complete health history with your doctor before starting any new medicine.
Lupisit-M 500 Tablet does not usually interfere with the ability to drive or operate machinery. However, if you experience side effects like dizziness or fatigue, avoid these activities until you feel better.
If you know you're allergic to Metformin, Sitagliptin, or any other ingredients in Lupisit-M 500 Tablet, avoid using this medicine. Always inform your doctor about any allergies or adverse reactions to medicines.
It's always best to consult a doctor before giving this medicine to children.
Older patients should take Lupisit-M 500 Tablet under medical supervision as they may be more susceptible to its side effects. If you are an older patient, your doctor will guide you based on your health status before starting this medicine.
Lupisit-M 500 Tablet interacts with the following medicines:
Diuretics: Medicines like furosemide and hydrochlorothiazide may increase the risk of lactic acidosis when taken with Lupisit-M 500 Tablet due to their effect on kidney function.
Corticosteroids: Medicines such as prednisolone can raise blood sugar levels, potentially reducing the effectiveness of Lupisit-M 500 Tablet in managing diabetes.
Thyroid products: Medications like levothyroxine can cause hyperglycaemia, which could decrease the effectiveness of Lupisit-M 500 Tablet.
Oral contraceptives: Birth control pills like ethinyl estradiol and levonorgestrel may increase blood sugar levels, potentially reducing the efficacy of Lupisit-M 500 Tablet.
Lupisit-M 500 Tablet should be taken with meals to reduce the gastrointestinal side effects. Specific food interactions have not been reported.
Lupisit-M 500 Tablet interacts with the following diseases:
Kidney Disease: Patients with severe renal impairment should not use Lupisit-M 500 Tablet due to the increased risk of lactic acidosis.
Liver Disease: The medication should be avoided in patients with liver disease as they are at higher risk for lactic acidosis.
Heart Failure: Patients at risk for heart failure should be carefully monitored while taking this medication due to a potential association between DPP4 inhibitor treatment and heart failure.
The dosage of Lupisit-M 500 Tablet you take daily should be as prescribed by your doctor. This can vary based on individual factors like the severity of your condition and how you respond to the medicine. Always follow your doctor's instructions and never exceed the prescribed dosage without consulting them.
An overdose of Lupisit-M 500 Tablet may lead to common side effects like nausea, headaches, and diarrhoea. In case you experience these symptoms persistently after taking more than the recommended dose, inform your doctor.
If you forget to take a dose of Lupisit-M 500 Tablet, take it as soon as you remember. However, if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Avoid increasing your dosage without consulting your doctor.
Store Lupisit-M 500 Tablet at a temperature below 30°C.
Keep it away from excessive light and moisture.
Ensure the medicine is kept out of reach of children.
Always check the expiry date on the pack before use.
Maintain a balanced diet low in sugar and saturated fats to help manage type 2 diabetes better.
Regular physical exercise, like brisk walking or cycling, can help improve insulin sensitivity and keep your blood sugar levels in control.
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Type 2 Diabetes Mellitus |
| Drug Category | DPP 4 Inhibitor, Biguanide |
| Therapeutic Category | Antidiabetic |
Lupisit-M 500 Tablet is used to manage type 2 diabetes in adults, alongside diet and exercise.
It contains metformin that reduces the liver's sugar production and sitagliptin that controls postmeal insulin levels, thereby managing blood sugar.
No, this medicine is not suitable for managing type 1 diabetes or diabetic ketoacidosis.
Take the missed dose as soon as you remember, unless it's nearly time for your next dose. Do not take double the dose.
While some people may see improvements within two weeks, optimal results generally appear after about three months of continuous usage.
Caution is advised while taking Lupisit-M 500 Tablet if you are pregnant or breastfeeding. It is best to consult your doctor before taking this medicine.
No, the tablet should be swallowed whole with water; do not break, chew or crush it.
Check out Editorial Policy
Merck Sharp & Dohme Corp. (2007). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/022044s042lbl.pdf
Merck Sharp & Dohme Corp. (2006). Highlights of prescribing information [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s019lbl.pdf
Sitagliptin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01261
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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