Janumet 50mg/500mg Tablet contains two active ingredients: sitagliptin and metformin.
- Sitagliptin: It helps lower blood sugar levels by increasing the release of insulin and reducing the amount of glucose produced by the liver. Sitagliptin acts by inhibiting an enzyme called DPP-4 (dipeptidyl peptidase 4), which in turn increases the levels of incretin hormones responsible for stimulating insulin release and decreasing glucagon secretion.
- Metformin: Metformin reduces the amount of glucose absorbed from food into the bloodstream and also improves the body's response to insulin. It primarily works by activating an enzyme called AMPK (AMP-activated protein kinase), which leads to decreased glucose production in the liver and increased glucose uptake by muscles.
The combination of these two ingredients in Janumet 50mg/500mg Tablet works synergistically to effectively control high blood sugar levels in individuals with type 2 diabetes mellitus. By enhancing insulin production, reducing glucose production, and improving insulin sensitivity, Janumet 50mg/500mg Tablet helps maintain optimal blood sugar levels by addressing multiple aspects of glucose metabolism.