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Xylocaine NF Cream is used to relieve pain and discomfort associated with anal fissures by numbing the area and helping reduce spasm-related pain during healing. It helps make bowel movements more comfortable and supports recovery when used along with medical advice and proper local care. Apply only as prescribed, avoid using on broken/infected areas unless advised, and inform your doctor if symptoms persist, bleeding increases, or irritation occurs.
Xylocaine NF Cream is used to relieve pain, burning, and discomfort associated with anal fissures. It helps numb the affected area, reducing irritation and itching during bowel movements. Regular use supports healing by providing quick and localised pain relief in both acute and chronic fissures.
Follow these steps while using Xylocaine NF Cream:
Ensure that the area around the anal canal is clean and dry before application.
Apply the prescribed amount of the cream to the anal fissure and surrounding area.
Gently massage the cream into the skin.
Wash your hands immediately after applying the cream to prevent any potential spread of infection.
Remember, this medicine is for external use only. For specific advice on usage and dosage, always consult your doctor.
Xylocaine NF Cream is applied topically.
Common side effects of Xylocaine NF Cream include redness, itching, burning sensation, skin rash, headache, dizziness, low blood pressure, nausea, and indigestion.
Most side effects are temporary and generally harmless, resolved by discontinuing Xylocaine NF Cream. However, if you experience severe side effects or worsening symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Gastrointestinal upset: If you experience discomfort in your stomach after using this cream, try having a meal before application.
Hypotension: If you feel light-headed after using Xylocaine NF Cream, consider applying it before bedtime.
Xylocaine NF Cream contains two active ingredients:
Lidocaine (1.5%): This local anaesthetic works by temporarily blocking nerve signals in the area where it's applied. By doing this, it prevents pain sensations from reaching your brain. Lidocaine achieves this effect by stabilising the neuronal membrane, which inhibits the ionic fluxes needed to start and conduct nerve impulses.
Nifedipine (0.3%): Classified as a calcium channel blocker, nifedipine acts on the smooth muscle cells lining your anal canal, making them relax. This action helps relieve painful spasms associated with anal fissures and increases blood flow to the area, promoting tissue healing. Nifedipine achieves this by blocking the influx of calcium ions into vascular smooth muscle cells and cardiac myocytes.
If you are pregnant, caution is advised while using Xylocaine NF Cream. It is best to consult your doctor before applying this medicine.
For breastfeeding mothers, caution is advised when using Xylocaine NF Cream. Please consult your doctor for proper guidance.
As this cream is applied topically, interactions with alcohol are very rare. However, always practice moderation when consuming alcohol and consult a doctor.
This medicine may be used with caution if you have mild to moderate liver impairment. It is not recommended for severe liver diseases. Discuss your liver health with your doctor before starting Xylocaine NF Cream.
If you have kidney issues, it's a good idea to discuss them with your doctor before starting to use Xylocaine NF Cream. This medicine might affect kidney function.
As this is a topical cream, it does not typically affect abilities related to driving or operating machinery.
Xylocaine NF Cream should not be used if you have known allergies to lidocaine, nifedipine or other components of the formulation. Always inform your doctor about any allergic reactions you've had in the past.
Caution is advised while administering Xylocaine NF Cream to children under 18 years of age. Always consult your doctor before giving any medicine to a child.
Older patients should use Xylocaine NF Cream under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.
Xylocaine NF Cream interacts with the following medicines:
CYP3A4 Inhibitors: Medicines like cimetidine and erythromycin can potentially increase the toxicity of lidocaine present in Xylocaine NF Cream.
CYP3A4 Inducers: Medicines like rifampicin and phenytoin may decrease the levels of nifedipine, an active ingredient in Xylocaine NF Cream.
Antihypertensives: Combining other blood pressure-lowering medicines with Xylocaine NF Cream could result in an additional lowering of blood pressure due to the effect of nifedipine.
There are no known food interactions with Xylocaine NF Cream. This cream is for external use only, so it's unlikely to interact with any foods or beverages.
Xylocaine NF Cream interacts with the following diseases:
Liver Disease: As the liver metabolises lidocaine and nifedipine, individuals with severe liver disease should use this cream cautiously.
Kidney Disease: Lidocaine and nifedipine are excreted by the kidneys. Hence, individuals with severe kidney disease should be cautious while using Xylocaine NF Cream.
Your doctor will guide you on how to apply Xylocaine NF Cream daily. The dosage may vary based on your condition and your response to the medicine. Always follow your doctor's instructions.
If you mistakenly apply more Xylocaine NF Cream than recommended, you might experience minor local skin reactions or discomfort. If symptoms persist or worsen, inform your doctor about it.
If you forget to apply Xylocaine NF Cream, do so as soon as you remember. However, if it's nearly time for the next application, skip the missed dose and continue with your schedule. Avoid extra applications without consulting your doctor.
Check the storage guidelines for Xylocaine NF Cream:
Store Xylocaine NF Cream at a temperature not more than 25°C. Do not freeze it
Keep the product away from direct heat, light and moisture.
Always ensure the tube is tightly closed when not in use.
Keep children out of reach for their safety.
Avoid contact with your eyes.
Remember to use this medicine before its expiry date.
Here are the dietary guidelines to be followed while using Xylocaine NF Cream:
Increase your intake of dietary fibre. This can help prevent constipation which could exacerbate anal fissures. Foods high in fibre include fruits, vegetables, whole grains and legumes.
Stay well-hydrated by drinking plenty of water throughout the day. Dehydration can lead to hard stools, making bowel movements painful if you have an anal fissure.
| Available Dosage Types | Cream |
| Habit Forming | No |
| Ailment | Anal Fissures |
| Drug Category | Local Anaesthetic, Calcium Channel Blocker |
| Therapeutic Category | Pain Management |
Xylocaine NF Cream is used to manage the pain, irritation, and itching caused by anal fissures.
The medicine numbs the painful area and helps relax the muscle around the anal canal, reducing pain and promoting healing.
The numbing effect of the cream is felt within 3-5 minutes of application. Noticeable improvement in symptoms is usually seen within 1-2 weeks.
No, this cream is specifically formulated for anal fissures only. Consult your doctor before using it for other conditions.
It's meant for short-term treatment up to 6-8 weeks. Prolonged use should be under medical supervision.
You should apply the prescribed amount of the cream to the affected area around your anus 2-3 times daily or as directed by your doctor.
Use with caution if you have severe liver or kidney disease or a known hypersensitivity to lidocaine or nifedipine. Always consult your doctor first.
Check out Editorial Policy
DailyMed. (n.d.). Lidocaine- Lidocaine Cream. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm
DrugBank. (n.d.). Lidocaine. https://go.drugbank.com/drugs/DB00281
U.S. Food and Drug Administration. (2018). Lidocaine Hydrochloride and Hydrocortisone Acetate https://www.accessdata.fda.gov/drugsatfda_docs/label/2018/019941s021lbl.pdf
U.S. Food and Drug Administration. (2019). Nifedipine https://www.accessdata.fda.gov/drugsatfda_docs/label/2019/021976s056,202895s027lbl.pdf
Zhang, J., & Ho, K. Y. (1999). Lidocaine https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10404091/
Kc, D. C., & Chinnabovi, D. (2019). Effect of topical nifedipine in treatment of chronic anal fissure. International Journal of Surgery Science, 3(3), 82–83. https://doi.org/10.33545/surgery.2019.v3.i3b.152
Momayez Sanat, Z., Mohammadi Ganjaroudi, N., & Mansouri, M. (2023). The effect of topical nifedipine versus diltiazem on the acute anal fissure: A randomized clinical trial. Middle East Journal of Digestive Diseases, 15(2), 121–125. http://mejdd.org/index.php/mejdd/article/view/2804
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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