Glimp M 2500 Tablet Sr 10

Glimp M2 Sr Tablet 10

Zydus Healthcare Ltd

Strip of 10 Units

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MRP ~~₹154.55~~

₹77.12

₹15.46/Units

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

Glimp M2 SR Tablet is a medication primarily used to manage blood sugar levels in adults diagnosed with type 2 diabetes mellitus. This oral medication is a combination medicine that falls into the category of antidiabetic medicines.

In addition to its primary function, this medicine assists in improving the body's response to insulin, a natural substance that controls the amount of glucose in the blood. It also reduces the amount of glucose produced by your liver and absorbed by your stomach or intestines.

Before you start taking this medicine, it is essential to consult your doctor who will guide you on the correct dosage and frequency. Make sure to inform your doctor about any existing health conditions or ongoing medications. If you experience any side effects while using this medicine, notify your doctor promptly. Adhere strictly to your doctor's instructions and continue the medicine for the duration recommended by them for optimal results.

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Glimp M2 SR Tablet is used is to manage blood sugar levels in people with type 2 diabetes mellitus when dietary measures, physical exercise, and weight loss alone are insufficient to control blood glucose.

Directions for Use of Glimp M2 Sr Tablet 10

Ensure you use Glimp M2 SR Tablet correctly with these guidelines:

Follow the dosage and timing instructions provided by your doctor precisely.
Do not change or exceed the prescribed dose without consulting your doctor.
Consult your doctor before discontinuing the medication; do not stop taking it without their guidance.
Adhere to the dietary recommendations given by your doctor.

Glimp M2 SR Tablet is taken orally.

The Glimp M2 SR Tablet may cause the following side effects:

Hypoglycemia
Dizziness
Nausea and vomiting
Stomach Upset
Headache

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Glimp M2 SR Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Hypoglycaemia: Ensure to have regular meals throughout the day when taking this medicine.

Glimp M2 SR Tablet consists of two active ingredients:

Glimepiride (2 mg): As a sulfonylurea, glimepiride acts by stimulating the release of insulin from functioning pancreatic cells and improving the sensitivity of peripheral tissues to insulin. It binds with specific receptors on pancreatic cell surfaces, stabilising key potassium channels and resulting in a decrease in potassium efflux which in turn triggers insulin secretion.
Metformin (500 mg): This biguanide medicine works by reducing hepatic glucose production and decreasing intestinal absorption of glucose, thereby improving insulin sensitivity. It boosts peripheral glucose uptake and utilisation while suppressing glucose production in the liver. Unlike glimepiride, metformin does not stimulate insulin secretion. The sustained release formulation ensures effective plasma levels are maintained over 24 hours.

Pregnancy

Glimp M2 SR Tablet is not recommended for use during pregnancy. If you are pregnant or planning to conceive, consult your doctor before taking this medication.

Breastfeeding

Glimp M2 SR Tablet is contraindicated in breastfeeding women. If you are nursing, it's advisable to discuss this with your doctor before starting this medicine.

Alcohol

Alcohol can intensify the effect of metformin on lactate metabolism. Therefore, it's best to avoid excessive alcohol intake while taking Glimp M2 SR Tablet.

Liver

Caution is advised while taking Glimp M2 SR Tablet in case of liver impairment. It's not recommended for severe liver diseases. If you have any liver-related issues, it's better to discuss them with your doctor before starting this medication.

Kidney

This medication is contraindicated in individuals with renal impairment. It's best to consult your doctor if you have a history of kidney problems before using Glimp M2 SR Tablet.

Using Machines & Driving

Glimp M2 SR Tablet may cause dizziness as a side effect. Avoid driving or operating heavy machinery until you know how the medicine affects you.

Allergy

Do not take Glimp M2 SR Tablet if you are allergic to glimepiride, metformin, or any other component of this medicine. Consult your doctor if you have any known allergies.

Children

Always consult your doctor before giving this medicine to a child.

Older Patients

Older patients should take Glimp M2 SR Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Glimp M2 SR Tablet interacts with the following medicines:

Antihypertensives such as captopril, and enalapril. The concomitant use of this tablet with antihypertensives can increase insulin sensitivity and potentiate blood glucose-lowering effects and may cause hypoglycemia.
Other anti-diabetic agents such as insulin. The concomitant use of this tablet with insulin can lead to hypoglycemia.
Antianginal agents such as ranolazine. It may increase the blood concentration of this tablet.
An anticonvulsant agent such as phenytoin. It may lead to hyperglycemia and may lead to loss of glycemic control.
Tyrosine kinase inhibitors such as vandetanib and crizotinib. It may increase the blood concentration of this tablet.
Antiretroviral agents such as dolutegravir. It may increase the blood concentration of this tablet.
H2 antagonist/antacid agent such as cimetidine. It may increase the blood concentration of this tablet.
Antifungal agents such as miconazole and fluconazole. The concomitant use can lead to severe hypoglycemia.
Carbonic anhydrase inhibitor/diuretic agents such as acetazolamide. The concomitant use may increase the blood glucose levels.
Antibiotics such as rifampicin. The concomitant use may increase the blood glucose levels.

Drug-Food Interactions

There are no specific food items that are known to interact with Glimp M2 SR Tablet.

Drug-Disease Interactions

Glimp M2 SR Tablet interacts with the following diseases:

Renal Impairment: Those suffering from kidney issues should avoid consumption of this medicine as it can worsen their condition.
Hepatic Impairment: Patients with liver disease should also exercise caution as Glimp M2 SR Tablet could exacerbate their condition.
Metabolic Acidosis: This medicine is not recommended for patients with metabolic acidosis, including diabetic ketoacidosis.

Daily Dose

The daily dose of Glimp M2 SR Tablet should be taken as directed by your doctor. The dosage might change based on individual factors like the severity of your condition and how you respond to the medicine. It's crucial to follow the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

Overdosing on Glimp M2 SR Tablet might cause low blood sugar. If you experience low blood sugar after taking more than the recommended dose, inform your doctor so that they can provide appropriate guidance.

Missed Dose

If you forget to take Glimp M2 SR Tablet at the usual time, take it as soon as you remember. However, if it is nearly time for your next dose, it is better to skip the missed one and get back to your regular schedule. It’s important not to increase your dosage without speaking to your doctor first.

Always store Glimp M2 SR Tablet in its original package.
Place it in a dry location, away from excessive light and moisture.
Always keep this medicine out of reach of children.
Use the Glimp M2 SR Tablet before the expiry date marked on the pack.

Incorporate a balanced diet rich in fibre and low in sugar to support blood glucose management. This helps enhance the effectiveness of Glimp M2 SR Tablet in managing type 2 diabetes.
Regular physical activity like brisk walking or cycling helps improve insulin sensitivity, complementing the action of Glimp M2 SR Tablet in maintaining glycemic control.

Fact Box

Drug Category	Oral hypoglycemic agents
Therapeutic Category	Antidiabetic
Available Dosage Types	Glimp M2 SR Tablet
Habit Forming	No
Ailment	Type 2 Diabetes Mellitus

What does the Glimp M2 SR Tablet do?

This medicine helps manage blood sugar levels in adults with type 2 diabetes.

How does Glimp M2 SR Tablet work?

It reduces blood sugar by increasing insulin release and sensitivity, and by decreasing liver glucose production and intestinal absorption of glucose.

When should I take the Glimp M2 SR Tablet?

You must take the medicine exactly as prescribed by your doctor.

Can I split, crush, or chew Glimp M2 SR Tablet?

No, you should take the tablet whole to ensure proper medicine release.

What are the contraindications for Glimp M2 SR Tablet?

People with kidney or liver impairment, metabolic acidosis, or known hypersensitivity to glimepiride or metformin should avoid this medicine.

What side effects can occur when taking Glimp M2 SR Tablet?

Common side effects include upper respiratory tract infection, diarrhoea, headache, nausea/vomiting, abdominal pain, dizziness, and low blood sugar.

Are there any special precautions while taking Glimp M2 SR Tablet?

People at risk of lactic acidosis or hypoglycemia should be closely monitored. Also, annual checks for vitamin B12 levels are advised.

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 8 years

Doctor of Medicine

Reviewed by

Dr. Chhavi Rosha

Health & Medical Content Writer | 8 years

BMS, FMC, MD Resident

Check out Editorial Policy

References

Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222

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