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Oxramet-S XR 1000 Tablet combines dapagliflozin, sitagliptin, and metformin to manage blood glucose levels in patients with type 2 diabetes. When used with diet and exercise, it helps prevent complications associated with high blood sugar.
Consult your doctor regarding the correct dosage and frequency. Inform your physician of any pre-existing conditions or ongoing medications and report side effects immediately while continuing the treatment as prescribed.
Oxramet S XR 1000 Tablet is used to manage type 2 diabetes mellitus in adults whose blood sugar levels are not adequately controlled by metformin alone. It combines dapagliflozin, sitagliptin, and metformin to provide comprehensive blood sugar control.
Here's how you should take Oxramet-S XR 1000 Tablet:
Take the tablet orally as advised by your doctor.
Ensure you swallow the tablet whole with a glass of water.
Avoid crushing, cutting, or chewing the tablet.
Don't take more than the recommended dose without consulting your doctor.
It's essential not to stop taking this medicine without speaking to your doctor first.
Oxramet-S XR 1000 Tablet is taken orally.
Oxramet-S XR 1000 Tablet may have the following common side effects:
Genital mycotic infections: This is a type of fungal infection that can affect the genitals.
Nasopharyngitis: Also known as the common cold, this can cause symptoms like a runny nose and sore throat.
Urinary tract infections
Headache
Diarrhoea
Nausea and vomiting
Upper respiratory tract infection: This refers to infections that can impact your upper airway, which includes your nose, throat, and sinuses.
Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Oxramet-S XR 1000 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here's how to manage some common side effects:
Diarrhoea: Try taking Oxramet-S XR 1000 Tablet with food.
Nausea and vomiting: Taking this medicine after meals may help lessen this effect.
Oxramet-S XR 1000 Tablet combines three active ingredients that work together to help manage blood sugar levels:
Dapagliflozin (10 mg): Dapagliflozin functions as a sodium-glucose cotransporter 2 (SGLT2) inhibitor. This means it reduces the amount of glucose absorbed back into the blood by the kidneys, leading to more glucose being removed from the body through urine.
Metformin (1000 mg): Metformin is a biguanide. It works by decreasing the production of glucose in the liver and reducing its absorption in the intestines. Additionally, it helps your body use up more glucose effectively.
Sitagliptin (100 mg): As a dipeptidyl peptidase-4 (DPP-4) inhibitor, sitagliptin helps increase insulin levels when needed and decrease the production of glucose when it's high.
Together, these ingredients help manage blood sugar levels effectively throughout the day.
Oxramet-S XR 1000 Tablet is not recommended during pregnancy. If you are pregnant or planning a baby, ensure you discuss this with your doctor before starting this medicine.
This medicine is not advised for breastfeeding women. It's crucial to consult your doctor to understand the potential risks and benefits before taking Oxramet-S XR 1000 Tablet.
Caution is advised while consuming alcohol when taking this medicine. Alcohol can enhance the effect of metformin on lactate metabolism and increase the risk of lactic acidosis.
If you have liver health issues, it's best to consult your doctor before taking Oxramet-S XR 1000 Tablet. This is because liver function may be affected by this medicine.
This medicine is contraindicated in severe renal impairment or dialysis.
There's no known effect of Oxramet-S XR 1000 Tablet on your ability to drive or use machines. Still, if you feel unwell after taking the medicine, avoid such activities until you feel better.
Do not take Oxramet-S XR 1000 Tablet if you have had serious hypersensitivity reactions to dapagliflozin, metformin, sitagliptin, or any other components of the medicine.
This medicine is meant for adults. It should not be given to children under 18 years of age unless specifically advised by a doctor.
For older patients above 70 years of age, caution is advised while taking Oxramet-S XR 1000 Tablet. Older patients might have liver and kidney issues and could be on other medication. Your doctor will guide you based on your health status.
Oxramet-S XR 1000 Tablet interacts with the following medicines:
Diuretics: Medicines such as furosemide or hydrochlorothiazide may interact with Oxramet-S XR 1000 Tablet, increasing the risk of dehydration and low blood pressure.
Insulin or insulin secretagogues: When taken with medicines like insulin or glipizide, Oxramet-S XR 1000 Tablet could increase the risk of low blood sugar (hypoglycaemia).
Carbonic anhydrase inhibitors: These include medicines like acetazolamide, which when combined with Oxramet-S XR 1000 Tablet might raise the risk of lactic acidosis.
Medicines that reduce metformin clearance: Medicines such as ranolazine, vandetanib, dolutegravir and cimetidine can increase the accumulation of metformin in your body.
There are no known food interactions with Oxramet-S XR 1000 Tablet.
Oxramet-S XR 1000 Tablet interacts with the following diseases:
Severe renal impairment: If you suffer from severe renal impairment or are in end-stage renal disease or on dialysis, you should avoid taking Oxramet-S XR 1000 Tablet.
Metabolic acidosis: In patients with acute or chronic metabolic acidosis, including diabetic ketoacidosis, this medicine may not be advisable.
Pancreatitis: If you have a history of pancreatitis, caution is advised when taking this medicine as its impact hasn't been fully studied.
Your doctor will prescribe the daily dosage of Oxramet-S XR 1000 Tablet. It's crucial to follow these instructions and not exceed the recommended dose without consulting your doctor.
If you accidentally take more than your prescribed dose of Oxramet-S XR 1000 Tablet, you may experience symptoms like nausea and diarrhoea. Inform your doctor if these symptoms persist.
If you forget to take your Oxramet-S XR 1000 Tablet, take it as soon as you remember. If it's nearly time for the next dose, skip the missed one. Never increase your dosage without consulting your doctor.
Keep Oxramet-S XR 1000 Tablet at room temperature, ideally between 20°C and 25°C.
Store it in a tight, light-resistant container to shield it from exposure to light.
Make sure it's kept away from moisture.
Always keep this medicine out of the reach of children.
Use the tablet before its expiry date for maximum effectiveness.
Regularly engage in physical activity. Moderate exercise such as walking or swimming can help manage blood glucose levels. Always consult your doctor before starting any new exercise regimen.
Maintain a balanced diet. Opt for foods with low sugar content and high fibre, such as whole grains, fruits, and vegetables to support effective diabetes management. Remember to consult your doctor for personalised dietary advice.
| Dosage Forms Available | Tablet |
| Habit Forming | No |
| Ailment | Type 2 Diabetes Mellitus |
| Drug Category | SGLT2 Inhibitor, Biguanide, DPP-4 Inhibitor |
| Therapeutic Category | Antidiabetic |
This medicine is used to improve blood sugar control in adults with type 2 diabetes, alongside diet and exercise.
It contains three active ingredients that lower blood glucose levels: dapagliflozin increases glucose excretion, metformin improves insulin sensitivity, and sitagliptin boosts insulin secretion.
You should take one tablet orally once a day with your morning meal. Remember not to crush, cut, or chew the tablet.
Common side effects include female genital yeast infections, nasopharyngitis (common cold), urinary tract infections, headache, diarrhoea, nausea and vomiting, and upper respiratory tract infection.
If you have a history of pancreatitis or severe kidney problems, consult your doctor before taking this medicine. Stay hydrated and maintain good hygiene to avoid infections.
Yes, it can interact with diuretics, insulin or insulin secretagogues, carbonic anhydrase inhibitors, medicines that reduce metformin clearance like ranolazine and vandetanib, and alcohol.
Store it at room temperature (20°C to 25°C), keep it in a tight container away from light and moisture, and out of reach of children and pets.
Check out Editorial Policy
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AstraZeneca. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/202293s020lbl.pdf
Merck Sharp & Dohme Corp. (2006). Highlights of prescribing information [Press release]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2012/021995s019lbl.pdf
Sahay, R. K., Giri, R., Shembalkar, J. V., Gupta, S. K., Mohan, B., Kurmi, P., Kumar, S. R., Sawardekar, V. M., Mishra, A., Murthy, L. S., Arya, V. V., Sonawane, A. R., Soni, P. N., Gofne, S. K., Karnawat, S. R., Rajurkar, M. N., Patel, P. M., Lakhwani, L. K., Mehta, S. C., & Joglekar, S. J. (2023). Fixed-Dose Combination of Dapagliflozin + Sitagliptin + Metformin in Patients with Type 2 Diabetes Poorly Controlled with Metformin: Phase 3, Randomized Comparison with Dual Combinations. Advances in Therapy, 40(7), 3227–3246. https://doi.org/10.1007/s12325-023-02523-z
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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