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Dapagliflozin + Metformin + Sitagliptin

Uses of Dapagliflozin + Metformin + Sitagliptin

  • Dapagliflozin + Metformin + Sitagliptin is predominantly used to manage type 2 diabetes mellitus in adults and belongs to the group of antidiabetic medications.

  • This combination may also be used in circumstances where blood sugar is not adequately controlled by metformin alone or by metformin in combination with either sitagliptin or dapagliflozin.

Side effects of Dapagliflozin + Metformin + Sitagliptin

  • Genital fungal infections

  • Common cold symptoms (nasopharyngitis)

  • Urinary tract infections

  • Diarrhoea

  • Nausea

How Dapagliflozin + Metformin + Sitagliptin works

  • Dapagliflozin is a sodium-glucose co-transporter 2 (SGLT2) inhibitor. It works by blocking the reabsorption of glucose (sugar) in the kidneys, leading to more sugar being passed out in urine, thereby reducing blood sugar levels.

  • Metformin is a biguanide. It acts by reducing the amount of glucose your liver produces and your intestines absorb. It also increases the body's response to insulin, which is a hormone that controls the distribution of sugar in the body.

  • Sitagliptin is a dipeptidyl peptidase-4 (DPP-4) inhibitor. It increases the levels of insulin produced by your body and reduces the amount of glucose made by your liver. Together, these medications work to manage blood sugar levels effectively in adults with type 2 diabetes.

Certified content

Written By

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Dr Nikita LoboMedical Editor & Reviewer| 7 years

BDS, MDS

Reviewed By

Dr. Chhavi Rosha
Dr. Chhavi Rosha Health & Medical Content Writer| 8 years

BMS, FMC, MD Resident

Expert Advice

Dosage Forms Available

  • Dapagliflozin + Metformin + Sitagliptin can be taken orally (tablet).

Age and Dose Restrictions

  • This combination medication is specifically meant for adults to manage their type 2 diabetes condition.

Contraindications

  • Dapagliflozin + Metformin + Sitagliptin is contraindicated in patients with type 1 diabetes. It should not be used by people with severe kidney impairment or individuals who have a known hypersensitivity to any of the active ingredients in this combination.

Other Medications to Avoid

  • This combination may interact with insulin and insulin secretagogues (such as glipizide, and glyburide), and diuretics (like hydrochlorothiazide, and furosemide).

Overdose and Missed Dose

  • An overdose of this combination could lead to symptoms such as confusion, vomiting, or abdominal pain. If you suspect an overdose, inform your doctor immediately.

  • If you miss a dose, take it as soon as you remember. However, if it is near the time of your next dose, skip the missed one. Do not double up on doses.

Management of Side Effects

Most side effects are temporary and generally harmless and resolve when discontinuing this medicine. However, if you experience any severe side effects or worsening of any of the symptoms, please consult your doctor.

  • To manage digestive issues like diarrhoea or nausea, try taking this medicine with food.

  • For prevention of genital fungal infections, maintain good personal hygiene.

  • Stay well-hydrated to reduce the risk of urinary tract infections and to ensure kidney health.

Use in Driving and Operating Machinery

  • Dapagliflozin + Metformin + Sitagliptin may cause dizziness or fatigue. If you experience these side effects, avoid driving and operating heavy machinery until you feel alert again.

Use in Pregnancy and Lactation

  • The use of this combination medicine during pregnancy or while breastfeeding should only be done under the guidance of your doctor. It is advised to consult your doctor before taking this medication in these conditions.

Caution in Other Conditions

  • Patients with liver disease, heart failure, or pancreatic disorders should exercise caution when taking Dapagliflozin + Metformin + Sitagliptin. Always inform your doctor about any existing medical conditions before beginning this medication.

Special Dietary and Lifestyle Recommendations

  • Regularly monitor your blood sugar levels to maintain optimal control over diabetes.

  • Limit consumption of processed foods, sweets, and sugary drinks.

Frequently asked questions

Dapagliflozin, one of the components of this combination, may cause some weight loss by increasing glucose excretion in the urine. However, weight loss is not the primary function of this medicine and any significant weight changes should be reported to your doctor.

No, you should not stop taking Dapagliflozin + Metformin + Sitagliptin without consulting your doctor first. Even if your blood sugar levels are controlled, stopping the medicine abruptly may lead to hyperglycaemia (high blood sugar).

Always consult your doctor before fasting or making any significant changes to your eating habits while taking Dapagliflozin + Metformin + Sitagliptin.

The safety of long-term use of Dapagliflozin + Metformin + Sitagliptin will depend on your individual health circumstances and should be assessed by your doctor.

There's no evidence to suggest that patients become physically or psychologically dependent on this medication.

No, it is essential to consult your doctor before starting any new medication. Dapagliflozin + Metformin + Sitagliptin is typically prescribed when blood sugar levels are not adequately managed by metformin alone or in combination with either dapagliflozin or sitagliptin.

While some lifestyle changes like a balanced diet and regular exercise can help manage diabetes, they cannot replace the effect of prescribed medication like Dapagliflozin + Metformin + Sitagliptin. Always consult your doctor before stopping any medication or starting any natural alternatives.

Terms & Conditions


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