Duopil 1/850 MG Tablet 10

Aristo Pharmaceuticals Pvt.ltd

Pack of 10 Units

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Old MRP ₹38.47

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Prescription required for this medicine

Store Below 30^o C

Composition

Glimepiride (1 Mg) + Metformin (850 Mg)

Duopil 1/850 MG Tablet 10 is used to manage type 2 diabetes mellitus in adults when diet and exercise alone are not enough to control blood sugar levels. It is a combination medicine that belongs to the class of oral antidiabetic medications.

In addition to controlling blood glucose levels, this medicine helps prevent long-term complications associated with uncontrolled diabetes. These complications include nerve damage, kidney problems, and cardiovascular issues that can develop when diabetes is not properly managed over time.

This medicine should be taken exactly as prescribed by your doctor. Before starting this medicine, inform your doctor about any pre-existing conditions you may have and any other medications you are currently taking. If you notice any side effects while using this medicine, notify your doctor promptly. Continue taking the medicine for the full duration prescribed by your doctor for optimal results.

Duopil 1/850 MG Tablet 10 is used for the following:

Treatment of type 2 diabetes mellitus in adults
Management of high blood glucose levels
Prevention of diabetic nerve damage
Prevention of diabetes-related kidney problems
Reduction of cardiovascular complications in diabetes
Improving glycaemic control when diet fails
Enhancing insulin sensitivity in peripheral tissues
Supplementing comprehensive diabetes management plans

Follow these instructions while taking Duopil 1/850 MG Tablet 10:

Swallow the tablet whole with a glass of water.
Do not crush, chew, or break the tablet.
Take it at the same time each day to maintain consistent blood sugar control.

Duopil 1/850 MG Tablet 10 is taken orally.

Duopil 1/850 MG Tablet 10 may have the following common side effects:

Diarrhoea
Nausea
Abdominal discomfort
Metallic taste
Hypoglycaemia: Blood sugar drops too low, causing symptoms like sweating, shakiness, confusion, and hunger

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Duopil 1/850 MG Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Taking Duopil 1/850 MG Tablet 10 with meals can help reduce feelings of sickness.
Diarrhoea: Taking this medicine with food rather than on an empty stomach may help lessen this side effect.

Duopil 1/850 MG Tablet 10 contains two active ingredients:

Glimepiride (1 mg): This component belongs to the sulfonylurea class of medicines. It stimulates the pancreatic beta cells (special cells in your pancreas) to release more insulin, helping move glucose from your bloodstream into cells for energy production or storage.
Metformin (850 mg): As a biguanide medicine, metformin works by reducing glucose production in the liver (a process called hepatic gluconeogenesis). It also increases insulin sensitivity in peripheral tissues like muscles, which enhances glucose uptake and utilisation by cells, thereby lowering blood sugar levels.

Pregnancy

Duopil 1/850 MG Tablet 10 is generally not recommended if you are pregnant. It is best to consult your doctor before taking this medicine.

Breastfeeding

Caution is advised while taking Duopil 1/850 MG Tablet 10 if you are breastfeeding. It is best to consult your doctor before taking this medicine.

Alcohol

Avoid alcohol completely while using Duopil 1/850 MG Tablet 10. Alcohol can increase your risk of developing low blood sugar (hypoglycaemia) and a rare but serious condition called lactic acidosis, which affects how your body processes energy.

Liver

Caution is advised while taking Duopil 1/850 MG Tablet 10 if you have liver problems. Discuss any liver-related concerns with your doctor before starting this treatment.

Kidney

Duopil 1/850 MG Tablet 10 is contraindicated if you have severe kidney problems. If you have any history of kidney issues, inform your doctor immediately.

Using Machines & Driving

Exercise caution when driving or operating machinery while taking Duopil 1/850 MG Tablet 10. This medicine may cause low blood sugar levels, which can affect your concentration and reaction times. If you experience dizziness or feel unwell, avoid these activities.

Allergy

If you have any known allergies to glimepiride, metformin, or other similar medicines, inform your doctor before taking Duopil 1/850 MG Tablet 10.

Children

Duopil 1/850 MG Tablet 10 is contraindicated for children under 18 years of age. This medicine is specifically designed to manage type 2 diabetes in adults.

Older Patients

Older patients should take Duopil 1/850 MG Tablet 10 under medical supervision, as they may be more susceptible to its side effects. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Duopil 1/850 MG Tablet 10 interacts with the following medicines:

Insulin and Other Antidiabetics: Medicines like insulin, pioglitazone, or repaglinide may increase the risk of hypoglycaemia (low blood sugar) when taken with Duopil 1/850 MG Tablet 10.
Beta-Blockers: Medicines like propranolol and atenolol can mask the warning symptoms of hypoglycaemia, making it difficult for you to recognise when your blood sugar is low.
NSAIDs: Anti-inflammatory medicines like ibuprofen and diclofenac may interact with glimepiride component, potentially altering blood sugar control.
Diuretics: Water tablets such as furosemide and hydrochlorothiazide may indirectly increase the risk of metformin toxicity when used in combination with Duopil 1/850 MG Tablet 10.
Kidney-Affecting Medicines: Medications like ranolazine, vandetanib, and cimetidine can interfere with metformin elimination from your body, increasing side effect risks.

Drug-Disease Interactions

Duopil 1/850 MG Tablet 10 interacts with the following diseases:

Kidney Disease: This medicine can accumulate in patients with poor kidney function, increasing the risk of lactic acidosis (dangerous acid buildup in the blood).
Heart Failure: Patients with heart failure requiring treatment should not take this medicine as it may worsen their condition and increase lactic acidosis risk.
Liver Disease: Caution is needed as the liver helps process both active ingredients in this medicine.
Vitamin B12 Deficiency: Long-term use may worsen existing vitamin B12 deficiency, potentially causing anaemia and nerve problems.

Daily Dose

The daily dose of Duopil 1/850 MG Tablet 10 should be taken as prescribed by your doctor. Your dosage may change based on your blood sugar levels and how well you respond to treatment. Never adjust the dose yourself without consulting your doctor.

Over Dose

Overdosing on Duopil 1/850 MG Tablet 10 may cause low blood sugar (hypoglycaemia), stomach discomfort, nausea, or dizziness. You might feel shaky, sweaty, confused or unusually tired. Contact your doctor if these symptoms occur.

Missed Dose

If you forget to take a dose, take it as soon as you remember. However, if it is nearly time for your next dose, skip the missed dose and continue with your regular schedule. Do not take a double dose.

Store at room temperature not exceeding 30°C.
Protect from moisture and excessive heat.
Keep the medicine in its original packaging until ready to use.
Keep out of reach of children.
Check the expiry date before use and do not take it if it has expired.
Avoid storing in bathrooms or other humid places.

Monitor your carbohydrate intake by choosing complex carbohydrates (whole grains, legumes) over simple sugars to help maintain steady blood glucose levels throughout the day.
Engage in regular physical activity for at least 30 minutes daily as exercise improves insulin sensitivity and helps your muscles use glucose more effectively.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 diabetes, hyperglycaemia
Drug Category	Insulin secretagogue and gluconeogenesis inhibitor
Therapeutic Category	Antidiabetic

What is Duopil 1/850 MG Tablet 10 used for?

Duopil 1/850 MG Tablet 10 is used to manage type 2 diabetes in adults when diet and exercise alone are not enough to control blood sugar levels.

What precautions should I take while using this medicine?

Avoid alcohol, stay hydrated, monitor your blood sugar regularly, and inform your doctor about all other medicines you take to prevent unwanted interactions.

Can I take Duopil 1/850 MG Tablet 10 during pregnancy?

You should consult your doctor before taking this medicine during pregnancy, as it may not be suitable, and alternatives might be recommended.

How should I take Duopil 1/850 MG Tablet 10?

Swallow the tablet whole; never crush, break, or chew it, as this affects how it works in your body.

What are the common side effects of Duopil 1/850 MG Tablet 10?

Common side effects include stomach discomfort, diarrhoea, nausea, metallic taste in the mouth, skin rash, and sometimes low blood sugar (hypoglycaemia).

What is hypoglycaemia and how do I recognise it?

Hypoglycaemia means low blood sugar. Signs include sweating, shakiness, hunger, confusion, headache, and dizziness. Keep glucose tablets or sweets handy for emergencies.

Do I need to adjust my diet while taking this medicine?

Yes, follow a balanced diet as recommended by your doctor. Regular meals help prevent low blood sugar and improve how well the medicine works.

Last Updated On 12 Sep. 2025 | 10:54AM (IST)

Certified Content

Written by

Dr. Nikhil Ambatkar

Medical Content Reviewer | 7 years

Ph.D, M.Tech, B.Tech

Reviewed by

Dr. Betina Chandolia

Lead Medical Content Reviewer | 10 years

BDS, MDS, PGCCL, PGDMH

Check out Editorial Policy

Manufacturer details

23 A, Shah Industrial Estate, Off Veera Desai Rd, Andheri West, Mumbai, Maharashtra 400053

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

MedlinePlus. (n.d.). Metformin. https://medlineplus.gov/druginfo/meds/a696005.html
Schernthaner, G. (1998). Safety and efficacy of glimepiride in type 2 diabetes mellitus: A review. Diabetes Research and Clinical Practice, 40(Suppl), S95–S103. https://pubmed.ncbi.nlm.nih.gov/9561345/
Langtry, H. D., & Balfour, J. A. (1998). Glimepiride. Drugs, 55(4), 563–584. https://doi.org/10.2165/00003495-199855040-00007
MedlinePlus. (n.d.). Glimepiride. https://medlineplus.gov/druginfo/meds/a696016.html
Corcoran, C., & Jacobs, T. F. (2023, August 17). Metformin. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK518983/
Foretz, M., Guigas, B., & Viollet, B. (2023). Metformin: update on mechanisms of action and repurposing potential. Nature Reviews Endocrinology, 19(8), 460–476. https://doi.org/10.1038/s41574-023-00833-4

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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