Trinexovas 20 Tablet 15

Macleods Pharmaceuticals Pvt.Ltd

Strip of 15 Units

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MRP ~~₹291.55~~

₹244.9

₹19.44/Units

16% off

*MRP inclusive of all taxes

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Prescription required for this medicine

Store Below 30° C

Composition

Chlorthalidone (12.5 Mg) + Cilnidipine (10 Mg) + Olmesartan Medoxomil (20 Mg)

Trinexovas 20 Tablet 15 is a triple-combination treatment used to manage severe hypertension (high blood pressure) when single medications are insufficient. It effectively lowers both systolic and diastolic blood pressure, which significantly reduces the risk of serious complications like heart attacks, kidney failure, and strokes.

Always follow your doctor's dosage instructions carefully. Regular monitoring of your blood pressure is essential to ensure the treatment continues to provide the intended cardiovascular protection.

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Trinexovas 20 Tablet 15 is used to manage high blood pressure (hypertension) in adults. It is especially useful when a single medication doesn't adequately control blood pressure, reducing the risk of heart attacks, strokes, kidney failure, and vision problems.

Swallow the tablet whole with a glass of water.
Avoid breaking or chewing the tablet.
It's crucial not to exceed the recommended dose unless your doctor advises otherwise.
Remember, stopping this medicine abruptly can have consequences; always consult your doctor before discontinuing.

Trinexovas 20 Tablet 15 is taken orally.

Common side effects of Trinexovas 20 Tablet 15 include dizziness, headache, nausea, diarrhoea, constipation, fatigue, muscle cramps, skin rash, and pruritus (itching). If symptoms persist, speak with your doctor.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Trinexovas 20 Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are a couple of tips for managing common side effects:

Nausea: Try taking Trinexovas 20 Tablet 15 with food to lessen this effect.
Fatigue and Weakness: If you feel excessively tired or weak after taking this medicine, consider adjusting your schedule to take it at night before bed.

Trinexovas 20 Tablet 15 combines three active ingredients that work together through different mechanisms to manage high blood pressure:

Chlorthalidone (12.5 mg): This thiazide-like diuretic increases the excretion of sodium and water from your body, reducing total blood volume and cardiac output, which helps achieve lower blood pressure.
Cilnidipine (10 mg): Cilnidipine is a long-acting dihydropyridine calcium channel blocker, which relaxes the smooth muscles in your blood vessel walls, causing them to widen or dilate, thereby reducing the blood pressure.
Olmesartan Medoxomil (20 mg): This angiotensin II receptor blocker prevents the strong blood vessel constricting effects of angiotensin II by selectively blocking its binding to receptors in the vascular smooth muscle, leading to dilation of blood vessels and lower blood pressure.

Pregnancy

Trinexovas 20 Tablet 15 is contraindicated during the second and third trimesters of pregnancy. If you are pregnant or planning to conceive, make sure to inform your doctor before starting this medicine.

Breastfeeding

Trinexovas 20 Tablet 15 is not recommended while breastfeeding. It's important to consult your doctor to understand the potential risks and benefits.

Alcohol

It is advisable to limit alcohol consumption while taking this medicine, as it might increase the risk of dizziness and fainting.

Liver

Caution is advised while taking Trinexovas 20 Tablet 15 if you have mild to moderate liver impairment. This medicine is not recommended for severe liver diseases. Discuss your liver health with your doctor before using this medication.

Kidney

If you have a history of kidney problems, caution is advised before taking Trinexovas 20 Tablet 15. Consult your doctor for guidance based on your health status.

Use In Driving And Operating Machinery

This medicine might cause dizziness or fatigue in some patients, affecting their ability to drive or operate machinery. Avoid such activities if you experience these symptoms.

Allergy

If you are allergic to any of the ingredients in Trinexovas 20 Tablet 15, avoid using this medicine and consult your doctor immediately.

Children

Trinexovas 20 Tablet 15 is not recommended for use in children under 18 years of age due to lack of sufficient data.

Older Patients

Older patients should take this medicine under medical supervision as they may be more susceptible to its side effects, particularly if they are over 70 years old or have existing kidney or liver issues. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Trinexovas 20 Tablet 15 interacts with the following medicines:

NSAIDs: Medications like ibuprofen and naproxen may reduce the blood pressure-reducing effect of the tablet and worsen kidney function.
Lithium: Taking this medicine alongside lithium could increase the risk of lithium toxicity.
Digoxin: Trinexovas 20 Tablet 15 may increase digoxin levels in your body.
Insulin and oral anti-diabetic drugs: Your doctor may need to adjust the dose of these medicines as this tablet could affect blood sugar levels.
Cholestyramine and colestipol: These medications reduce the absorption of one of the ingredients, olmesartan.
Alcohol, barbiturates, narcotics: Use of these substances with Trinexovas 20 Tablet 15 can increase the risk of low blood pressure when standing up (orthostatic hypotension).

Drug-Food Interactions

Trinexovas 20 Tablet 15 does not have any known specific food interactions.

Drug-Disease Interactions

Trinexovas 20 Tablet 15 interacts with the following diseases:

Liver disease: This medicine should be used with caution in patients with liver disease as it could worsen their condition.
Diabetes: This medication could impact blood sugar control, so frequent monitoring of glucose levels is necessary for diabetic patients while on this medication.
Gout: Patients with gout might see an increase in uric acid levels due to this medicine.

Daily Dose

The recommended daily dose of Trinexovas 20 Tablet 15 should be taken as advised by your doctor. The dosage may differ based on things like your health condition and how well your body responds to the medicine. It's crucial to stick to the recommended dosage and not alter it without consulting your doctor.

Over Dose

In case of an overdose of Trinexovas 20 Tablet 15, you may feel dizziness, weakness, or even changes in urine output. If you notice these or any unusual symptoms after taking more than the prescribed dose, consult your doctor immediately.

Missed Dose

If you realise you've missed a dose of Trinexovas 20 Tablet 15, take it as soon as you remember. But if it's nearly time for the next dose, skip the missed one and go back to your regular schedule. Don't increase your dosage without consulting your doctor.

Store Trinexovas 20 Tablet 15 in a cool and dry place, ideally at room temperature below 30°C.
Protect this medicine from excessive light and moisture.
Keep it out of reach of children to avoid accidental consumption.
Always check the expiration date before you take this medicine and do not use it if it has expired.

Since Trinexovas 20 Tablet 15 is used to manage hypertension, consider adopting a diet low in salt. Excessive sodium can elevate blood pressure levels.
Regular aerobic exercise such as walking, jogging, or swimming can also help lower your blood pressure. Remember to consult your doctor before starting any new exercise programme.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Hypertension
Drug Category	Diuretic, Calcium Channel Blocker, Angiotensin II Receptor Blocker
Therapeutic Category	Antihypertensive

What is the Trinexovas 20 Tablet 15 used for?

This medicine helps manage high blood pressure in adults when a single medication doesn't control blood pressure adequately.

Can Trinexovas 20 Tablet 15 cause ankle swelling?

Yes, Trinexovas 20 Tablet 15 might induce swelling in the ankles. When sitting for extended periods of time, please try to keep your feet up. If the issue continues, speak with your physician and follow their advice.

Can I take Trinexovas 20 Tablet 15 with or without food?

Yes, you can take this medicine with or without food, as it does not impact its effectiveness.

What are the possible side effects of Trinexovas 20 Tablet 15?

Common side effects include dizziness, headache, nausea, diarrhoea, fatigue, and muscle cramps, among others.

Can I stop taking Trinexovas 20 Tablet 15 when my blood pressure is normal or under control?

It is advisable to keep taking your medication because blood pressure might rise at any time, even when it is under control or returns to normal. Please contact your physician right away if your headache is bothering you consistently.

Are there any specific precautions before starting Trinexovas 20 Tablet 15?

Yes, it's essential to correct any salt or volume depletion before starting therapy and monitor renal function and serum potassium levels regularly.

Can I stop taking Trinexovas 20 Tablet 15 abruptly?

No, it's advised to gradually taper the dose over 1-2 weeks to avoid a sudden rise in blood pressure. Always consult your doctor before making any changes.

Last Updated On 30 Mar. 2026 | 5:51PM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 10 years

Doctor of Medicine

Reviewed by

Dr. Saniya K Mulla

Medical Content Writer | 7 years

MBBS

Check out Editorial Policy

Manufacturer details

Atlanta Arcade, Marol Church Rd, Bori Colony, Vijay Nagar Colony West, Marol, Andheri East, Mumbai, Maharashtra 400059

Country of origin: INDIA

Expiry on or after: January 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

DailyMed. (n.d.). Cilnidipine tablet. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=ef8023a3-b2be-436e-9085-576781950665
Dharmarajan, T. S., & Kanagala, M. R. (2015). Chlorthalidone: Mechanisms of action and effect on cardiovascular events. Current Hypertension Reports, 17(4), 33. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4397623/
DailyMed. (n.d.). Olmesartan medoxomil tablet. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=c42da0af-84dd-4220-bd40-139be51e8c00
U.S. Food and Drug Administration. (n.d.). Olmesartan medoxomil prescribing information. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/psg/PSG_012283.pdf
U.S. Food and Drug Administration. (2002). Label (PDF) - Cilnidipine. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2002/21286lbl.pdf

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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