Oxramet 5mg/500mg Tablet 14

Q: Are there any known drug interactions with Oxramet Tablets 5mg/500mg?

Yes, cationic medications, alcohol, diuretics, and carbonic anhydrase inhibitors can interact with this medicine. Always discuss all medications you're taking with your doctor.

Q: What are some common side effects of Oxramet Tablets 5mg/500mg?

Common side effects include female genital mycotic infections, nasopharyngitis, urinary tract infections, diarrhoea, headache, nausea, and vomiting.

Q: Can pregnant or breastfeeding women take Oxramet Tablets 5mg/500mg?

No, it's not recommended for use during the second and third trimesters of pregnancy or while breastfeeding. Always consult your doctor for advice.

Sun Pharma Laboratories Ltd.

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Composition

Dapagliflozin (5 Mg) + Metformin (500 Mg)

Oxramet Tablets 5mg/500mg is primarily used to manage blood sugar levels in adults with type 2 diabetes. This combination medicine belongs to a group of medications known as antihyperglycemic agents, specifically a sodium-glucose co-transporter 2 (SGLT2) inhibitor and a biguanide.

In addition to its main use, this tablet also helps in reducing the risk of hospitalisation due to heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple risk factors. It's particularly beneficial for adults with heart failure with reduced ejection fraction (NYHA class II-IV), where it lowers the risk of cardiovascular death and hospitalisation.

Before you start taking this medicine, it's important to consult your doctor about your dosage and frequency. Inform your doctor about any pre-existing conditions or ongoing medications before starting this medicine. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking this medicine for the duration prescribed by your doctor for optimal results.

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Assisting diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Reducing the risk of hospitalisation due to heart failure in adults with type 2 diabetes and established cardiovascular disease or multiple risk factors.
Lowering the risk of cardiovascular death and hospitalisation for heart failure in adults with heart failure with reduced ejection fraction (NYHA class II-IV).
Decreasing the risk of sustained decline in kidney function, end-stage kidney disease, cardiovascular death, and hospitalisation for heart failure in adults with chronic kidney disease at risk of progression.

Swallow the tablet whole with a glass of water.
Do not crush, cut, or chew the tablet.
Always take this medicine in the morning along with food.
It's key not to stop taking this medicine without consulting your doctor.

Oxramet Tablets 5mg/500mg is taken orally.

Female genital mycotic infections: This refers to fungal infections in the genital area in women.
Nasopharyngitis: A common cold or inflammation of the nose and pharynx.
Urinary tract infections
Diarrhoea
Headache
Nausea
Vomiting

Managing the Side Effects:

Here is how you can manage some common side effects:

Diarrhoea: Consider taking Oxramet Tablets 5mg/500mg with meals to lessen this effect.
Nausea: Try taking this medicine after meals, which could reduce feelings of sickness.

Dapagliflozin (5 mg): This works by inhibiting the SGLT2 in your kidneys. Basically, it stops the kidneys from reabsorbing glucose back into your body from your urine. The result is an increase in glucose excretion through urine, helping to lower blood glucose levels.
Metformin (500 mg): This ingredient works primarily by decreasing the production of glucose in your liver. It also reduces the absorption of glucose from your intestines and improves insulin sensitivity, meaning it helps your body use insulin more effectively. Unlike dapagliflozin, metformin does not stimulate insulin secretion.

Pregnancy

If you are pregnant, exercise caution while taking Oxramet Tablets 5mg/500mg. This medicine is not recommended during the second and third trimesters of pregnancy. It's best to consult your doctor before using this medicine.

Breastfeeding

While breastfeeding, it is not recommended to take Oxramet Tablets 5mg/500mg. You should consult your doctor to understand the potential risks and benefits.

Alcohol

Alcohol may intensify the effect of metformin on lactate metabolism, increasing the risk of lactic acidosis. It's advisable to avoid excessive alcohol intake while taking this medicine.

Liver

Individuals with liver health issues should use Oxramet Tablets 5mg/500mg with caution. The risk of lactic acidosis increases in situations like hepatic impairment, alcohol abuse, dehydration, sepsis, and hypoxia. Consult your doctor before using this medicine if you have any liver-related concerns.

Kidney

Oxramet Tablets 5mg/500mg is not recommended for individuals with severe renal impairment and those on dialysis. It's important to discuss your kidney health with your doctor before starting this medication.

Using Machines & Driving

There are no specific precautions regarding driving or operating machinery while taking Oxramet Tablets 5mg/500mg. However, if you feel unwell or experience any side effects that could affect your ability to concentrate or react, avoid such activities and speak with your doctor.

Allergy

Avoid taking Oxramet Tablets 5mg/500mg if you have a history of serious hypersensitivity reactions to dapagliflozin, metformin or any other components of the tablet. Consult your doctor if you experience any allergic reactions.

Children

Oxramet Tablets 5mg/500mg is not recommended for children under 18 years of age. You should always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should use Oxramet Tablets 5mg/500mg under medical supervision due to a higher incidence of side effects related to reduced intravascular volume and potential renal function issues. It is especially crucial if you are over 70 years of age, as you might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Cationic medications: Medicines like amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim or vancomycin may interact with Oxramet Tablets 5mg/500mg. This interaction could increase the accumulation of metformin in your body and raise the risk of lactic acidosis.
Carbonic anhydrase inhibitors: Medicines like topiramate, zonisamide and acetazolamide can interact with Oxramet Tablets 5mg/500mg. This combination can potentially increase your risk of developing lactic acidosis.
Diuretics: If you're taking diuretics such as furosemide or hydrochlorothiazide along with Oxramet Tablets 5mg/500mg, there might be an increased risk of low blood volume (hypovolemia).

Drug-Food Interactions

Alcohol: Consuming alcohol while taking Oxramet Tablets 5mg/500mg could increase the effect of metformin on lactate metabolism, raising the risk of lactic acidosis.

Drug-Disease Interactions

Renal Impairment: If you have severe kidney disease, end-stage renal disease or are on dialysis, Oxramet Tablets 5mg/500mg is not recommended as it could worsen your condition.
Metabolic Acidosis: In cases of acute or chronic metabolic acidosis, including diabetic ketoacidosis, it's advisable to avoid using Oxramet Tablets 5mg/500mg as it could exacerbate the acidosis.
Liver Impairment: In case of severe liver disease, Oxramet Tablets 5mg/500mg should be used with caution. The risk of lactic acidosis, a serious metabolic condition, may increase in such cases.

Daily Dose

The daily dose of Oxramet Tablets 5mg/500mg should be as directed by your doctor. This dosage may vary based on individual health circumstances and response to the medicine. It's crucial to adhere to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

Overdosing on Oxramet Tablets 5mg/500mg could lead to side effects like nausea, headache, and diarrhoea. If you suspect an overdose, it's important to inform your doctor about it.

Missed Dose

If you forget to take your Oxramet Tablets 5mg/500mg, take it as soon as you remember. However, if it's nearly time for your next dose, skip the one you missed and continue with your regular schedule. Don't increase the dosage without consulting your doctor.

Keep Oxramet Tablets 5mg/500mg in their original packaging to protect them from light and moisture.
Maintain a storage temperature below 30°C.
Ensure the medicine is out of sight and reach of children.
Always check the expiry date before taking your dose.

Adopt a balanced diet rich in whole grains, lean proteins, fruits, and vegetables, as it can help manage type 2 diabetes.
Regular physical activity, like brisk walking or cycling, can help manage blood sugar levels. Always consult your doctor before starting any exercise regime.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 diabetes, Heart failure, Chronic kidney disease
Drug Category	SGLT2 inhibitor, Biguanide
Therapeutic Category	Antidiabetic

What are Oxramet Tablets 5mg/500mg used for?

Oxramet Tablets 5mg/500mg are prescribed for managing type 2 diabetes in adults when diet and exercise alone do not provide enough control. It also aids in reducing the risk of cardiovascular complications.

How do Oxramet Tablets 5mg/500mg work?

This medicine contains two active ingredients: dapagliflozin, which increases glucose excretion through urine, and metformin, which reduces sugar production by the liver and improves insulin sensitivity.

How should I take Oxramet Tablets 5mg/500mg?

You should take this medicine once daily in the morning with food. The tablets must be swallowed whole without crushing, cutting, or chewing.

Can I take Oxramet Tablets 5mg/500mg if I have kidney problems?

If you have severe renal impairment (eGFR <30 mL/min/1.73m2), end-stage renal disease, or are on dialysis, it's recommended to avoid this medicine.

Are there any known drug interactions with Oxramet Tablets 5mg/500mg?

Yes, cationic medications, alcohol, diuretics, and carbonic anhydrase inhibitors can interact with this medicine. Always discuss all medications you're taking with your doctor.

What are some common side effects of Oxramet Tablets 5mg/500mg?

Common side effects include female genital mycotic infections, nasopharyngitis, urinary tract infections, diarrhoea, headache, nausea, and vomiting.

Can pregnant or breastfeeding women take Oxramet Tablets 5mg/500mg?

No, it's not recommended for use during the second and third trimesters of pregnancy or while breastfeeding. Always consult your doctor for advice.

Last Updated On 13 May. 2025 | 11:02AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 12 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 8 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

SUN HOUSE CTS No. 201, 201, Western Express Hwy, Ram Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

Expiry on or after: December 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

DailyMed. (n.d.). Dapagliflozin and Metformin hydrochloride tablet, film coated [AstraZeneca Pharmaceuticals LP]. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=eaf135b6-e378-4f62-a1e7-db45e23668c7
DailyMed. (n.d.). Oxramet - Dapagliflozin and Metformin hydrochloride tablet, film coated. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=6d6ee6f8-9650-ff4f-e053-2991aa0acf19&type=display
U.S. Food & Drug Administration. (2014). Clinical pharmacology and biopharmaceutics review(s). Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2014/202293orig1s000clinpharmr.pdf
U.S. Food & Drug Administration. (2006). Label and approval history. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf

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