Mexate 15 Tablet 10

Zydus Cadila

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Composition

Methotrexate (15 Mg)

Strength:

5 MG 7.5 MG 15 MG 2.5 MG 10 MG

Mexate 15 Tablet is primarily used to manage different forms of cancer. This medicine falls under the antimetabolites category, a class of medicines that inhibit cell growth and division.

In addition to managing cancer, this medicine is also employed to manage rheumatoid arthritis when it is severe and hasn't responded adequately to other treatments. Another use is in the management of severe psoriasis that hasn't responded effectively to other therapies.

The dosage and frequency of this medicine should be as directed by your doctor. Inform your doctor about any pre-existing health conditions or ongoing medications before starting on this medicine. Any side effects you experience while taking this medicine should be immediately reported to your doctor. It's essential to continue with the medicine for the duration prescribed by your doctor to get the best results.

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Mexate 15 Tablet is often used to manage:

Various types of cancer, including breast cancer, lung cancer, lymphomas, head and neck cancers and leukaemia
Severe cases of rheumatoid arthritis that have not responded adequately to other therapies
Severe psoriasis that has not shown improvement with other treatments

Here's how to take your Mexate 15 Tablet:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
Do not exceed the recommended dose without consulting your doctor.
It's crucial to continue taking this medicine as advised by your doctor.

Mexate 15 Tablet is taken orally.

Mexate 15 Tablet may have the following common side effects:

Nausea
Vomiting
Stomach discomfort
Mouth sores or ulcers
Fatigue: This medicine might cause you to feel tired or weak.
Headache
Hair loss
Increased susceptibility to infections: You could be more prone to catching various infections due to a lower immune response.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Mexate 15 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea and Vomiting: Try taking Mexate 15 Tablet with food.
Stomach discomfort: Consider taking this medicine after meals to lessen this effect.

Mexate 15 Tablet contains methotrexate (15 mg), which interacts with your body in the following ways:

Inhibits dihydrofolate reductase (DHFR): Methotrexate works by blocking an enzyme called DHFR in your body. DHFR is crucial for the synthesis of DNA and RNA in cells, which are essential for cell growth and division.
Interferes with nucleic acid production: By inhibiting DHFR, methotrexate disrupts the production of nucleic acids, which are vital for cell growth and function. This interference leads to cell death in cancer cells and helps reduce inflammation and slow down the overactive immune response in conditions like rheumatoid arthritis and psoriasis.

Pregnancy

Mexate 15 Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine.

Breastfeeding

Mexate 15 Tablet is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while consuming alcohol when taking Mexate 15 Tablet, as it can increase the risk of liver damage and other side effects. Always consult your doctor on this matter.

Liver

Caution is advised while taking Mexate 15 Tablet in case of mild to moderate liver impairment. It is not recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting this medicine. This medicine may affect liver function.

Kidney

Caution is advised before using Mexate 15 Tablet if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

Due to possible side effects such as dizziness or confusion, caution is advised when driving or operating heavy machinery when taking this medicine.

Allergy

If you are allergic to methotrexate or any other ingredients in Mexate 15 Tablet, do not take this medicine. Always inform your doctor about any allergies before starting a new medication.

Children

Caution is advised while giving Mexate 15 Tablet to children under 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Older patients should take Mexate 15 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Older patients might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Mexate 15 Tablet interacts with the following medicines:

NSAIDs: Medications like ibuprofen and naproxen might increase the potential risks when taken with Mexate 15 Tablet. It can heighten the levels of methotrexate in your body, potentially leading to increased side effects.
Antibiotics: Certain antibiotics, such as trimethoprim-sulfamethoxazole and penicillins, may interact with Mexate 15 Tablet, possibly leading to increased methotrexate levels in your body and heightened side effects.
Anticonvulsants: Medicines like phenytoin and carbamazepine, used for controlling seizures, may decrease the effectiveness of Mexate 15 Tablet when taken together.
Immunosuppressants: Concomitant use of medicines like cyclosporine and tacrolimus with Mexate 15 Tablet could potentially increase the risk of infections due to suppression of the immune system.

Drug-Food Interactions

Drug-Disease Interactions

Mexate 15 Tablet interacts with the following diseases:

Liver disease: If you have liver disease, using Mexate 15 Tablet could potentially exacerbate your condition due to possible increased toxicity.
Kidney disease: In patients with kidney disease, Mexate 15 Tablet should be used cautiously as it could potentially worsen kidney function.
Active infections: If you have an active infection, using this medicine may increase the risk of worsening your condition due to its immunosuppressive properties.
Blood disorders or bone marrow suppression: If you have any blood disorders or bone marrow suppression, Mexate 15 Tablet could potentially worsen your condition due to its effect on bone marrow cells.
Peptic ulcers or ulcerative colitis: Use of Mexate 15 Tablet might aggravate these conditions due to its potential irritative effect on the digestive tract.

Daily Dose

Your doctor will determine the daily dose of Mexate 15 Tablet based on your individual condition and response to the medication. It's crucial that you stick to this prescribed dose to manage your condition effectively. For more specific instructions regarding the dosage, refer to the package insert.

Over Dose

Overdosing on Mexate 15 Tablet may lead to symptoms like nausea, vomiting, and fatigue. If you experience these symptoms after taking a larger than prescribed dose, make sure to inform your doctor about it.

Missed Dose

If you forget to take your regular dose of Mexate 15 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the one you missed and continue with your usual schedule. Never take an extra tablet without consulting your doctor.

Store your Mexate 15 Tablet in a cool, dry place, ideally at room temperature.
Keep the product away from direct sunlight and moisture.
Ensure the medicine is kept out of reach and sight of children.
Always remember to use this medicine before its expiry date.

For those managing cancer, consider a balanced diet rich in fruits, vegetables, lean proteins and whole grains. This can help your body stay strong and recover faster.
If you're taking Mexate 15 Tablet for rheumatoid arthritis or psoriasis, try to include omega-3 fatty acids in your diet. Foods like fish, chia seeds, and walnuts are high in these healthy fats and can help reduce inflammation.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Cancer, Rheumatoid Arthritis, Psoriasis
Drug Category	Antimetabolite
Therapeutic Category	Chemotherapeutic

What is Mexate 15 Tablet used for?

Mexate 15 Tablet is primarily used to manage certain cancers, severe psoriasis, and active rheumatoid arthritis in adults.

How does Mexate 15 Tablet work?

The medicine works by reducing cell growth and division, which helps manage inflammation and slow down disease progression.

Can I take Mexate 15 Tablet with food?

You must take the medicine as directed by your doctor.

How long does it take for Mexate 15 Tablet to work?

The onset varies based on the condition. For cancer, effects may be seen in weeks, while for arthritis and psoriasis, it may take longer.

Is it safe to drink alcohol while taking Mexate 15 Tablet?

No, alcohol should be avoided during medication as it can heighten the risk of liver damage and other side effects.

What should I do if I miss a dose of Mexate 15 Tablet?

If you miss a dose, take it as soon as you remember unless it's nearly time for the next one - don't double the dose.

Can pregnant women take Mexate 15 Tablet?

No, this medicine is contraindicated in pregnancy as it can cause severe birth defects or fetal death. Effective contraception is necessary during treatment.

Last Updated On 13 May. 2025 | 10:33AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

5V74+4P2, Jay Prakash Nagar, Goregaon, Mumbai, Maharashtra 400063

Country of origin: INDIA

Expiry on or after: November 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

West-Ward Pharmaceuticals Corp. (2020). Highlights of prescribing information. https://www.accessdata.fda.gov/drugsatfda_docs/label/2020/040054s015,s016,s017.pdf
Methotrexate: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00563
DailyMed - METHOTREXATE SODIUM tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89c05ea3-3be1-46dd-b112-29c436fd7289
Methotrexate sodium (Cancer treatment). (2008, May 21). Cancer.gov. https://www.cancer.gov/about-cancer/treatment/drugs/methotrexate
Onda, K., Honma, T., & Masuyama, K. (2023). Methotrexate-related adverse events and impact of concomitant treatment with folic acid and tumor necrosis factor-alpha inhibitors: An assessment using the FDA adverse event reporting system. Frontiers in Pharmacology, 14. https://doi.org/10.3389/fphar.2023.1030832

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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