Mexate 10 Tablet 10

Zydus Healthcare Ltd

STRIP of 10 Units
STRIP of 4 Units

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MRP ~~₹139.54~~

₹111.63

₹13.95/Units

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Composition

Methotrexate (10 Mg)

Strength:

5 MG 7.5 MG 15 MG 2.5 MG 10 MG

Noltrexate-10 Tablet is primarily used to manage various types of cancers. This medicine is a member of the antimetabolite class of medications.

This tablet is also used to manage severe cases of rheumatoid arthritis, severe psoriasis, especially plaque-type, and psoriatic arthritis in adult patients who have tried other treatments but their illness has not improved.

Before you begin taking this medication, it's important to consult your doctor about the appropriate dosage and frequency. Make sure to inform your doctor about any preexisting conditions or current medications. While on this medicine, keep your doctor informed about any side effects you might experience. For optimal results, continue taking the medication for the entire duration prescribed by your doctor.

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Noltrexate-10 Tablet is used for managing the following conditions:

Manage various types of cancers
Active rheumatoid arthritis
Severe psoriasis, especially plaque-type
Psoriatic arthritis in adult patients

When taking Noltrexate-10 Tablet, follow these guidelines:

Swallow the tablet whole with a glass of water.
Avoid crushing or chewing the tablet.
Do not exceed the recommended dose without consulting your doctor.
It is crucial not to discontinue this medicine without speaking to your doctor first.

Noltrexate-10 Tablet is taken orally.

Noltrexate-10 Tablet may have the following common side effects:

Low blood cell counts: This might make you more prone to infections and fatigue.
Nausea, vomiting
Diarrhoea
Unusual fatigue, headache
Dizziness
Loss of appetite
Red rash
Hair loss
Stomatitis (soreness of the mouth and lips

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Noltrexate-10 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: Try taking Noltrexate-10 Tablet with food or milk to lessen this feeling of sickness.
Diarrhoea: Consider taking this medicine after meals to reduce stomach upset.

Noltrexate-10 Tablet contains methotrexate (10 mg), which acts on your body in the following ways:

It works by inhibiting the enzyme dihydrofolate reductase, which is essential for DNA synthesis and cell replication. This action slows the growth of rapidly dividing cells, making it effective in treating cancers like leukemia and certain autoimmune diseases, such as rheumatoid arthritis and psoriasis. Methotrexate reduces inflammation and suppresses the immune system to control disease progression. It is used under strict medical supervision due to potential side effects.

Pregnancy

Noltrexate-10 Tablet is contraindicated if you are pregnant. If you are pregnant or planning to conceive, it's crucial to consult your doctor before starting this medicine.

Breastfeeding

Noltrexate-10 Tablet is contraindicated for breastfeeding women. Make sure to discuss this with your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised when drinking alcohol while taking Noltrexate-10 Tablet, as it can increase the risk of liver damage. It's best to consult your doctor before taking this medicine.

Liver

Caution is advised while taking Noltrexate-10 Tablet if you have mild to moderate liver impairment. This medicine is not recommended for severe liver diseases. If you have any liver problems, discuss them with your doctor before starting this medication.

Kidney

If you have a history of kidney problems, consult your doctor before taking Noltrexate-10 Tablet.

Using Machines & Driving

Noltrexate-10 Tablet may cause dizziness, drowsiness, or visual disturbances. Exercise caution while driving or operating machinery when taking this medicine.

Allergy

If you have a known allergy to methotrexate or any other components of Noltrexate-10 Tablet, it's best not to take this medicine without consulting your doctor.

Children

Noltrexate-10 Tablet should not be given to children under the age of 18 years unless prescribed by a doctor.

Older Patients

Older patients should take Noltrexate-10 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Noltrexate-10 Tablet interacts with the following medicines:

Non-Steroidal Anti-Inflammatory Drugs (NSAIDs): Medicines like ibuprofen and naproxen may interact with Noltrexate-10 Tablet, potentially increasing the risk of side effects.
Certain Antibiotics: Medicines such as chloramphenicol, penicillin, sulfonamides, co-trimoxazole, trimethoprim / sulfamethoxazole, ciprofloxacin and tetracyclines may interact with this tablet, altering its absorption and effectiveness.
Proton pump inhibitors (PPIs): Medicines like omeprazole or lansoprazole may affect the absorption of this tablet.
Antiseizure medications: Phenytoin, when taken alongside Noltrexate-10 Tablet, can alter the latter's effectiveness.

Drug-Disease Interactions

Noltrexate-10 Tablet interacts with the following diseases:

Liver Disease: Patients with liver disease should exercise caution while taking this medicine as it could potentially worsen their condition.
Kidney Disease: Caution is advised for those with kidney disease as this tablet might affect kidney function.
Immune System Disorders: Due to its potential to suppress the immune system, careful monitoring is required when using Noltrexate-10 Tablet in patients with immune disorders.

Daily Dose

The daily dose of Noltrexate-10 Tablet should be taken as prescribed by your doctor. Follow the prescribed dosage and consult your doctor before making any changes.

Over Dose

If you accidentally take more than the prescribed dose of Noltrexate-10 Tablet, you may experience symptoms like nausea or abdominal discomfort. If these symptoms persist or worsen, inform your doctor.

Missed Dose

In case you forget to take your regular dose of Noltrexate-10 Tablet, take it as soon as you remember. However, if it's nearly time for the next dose, skip the missed one and continue with your regular dosage schedule. Avoid increasing your dosage without consulting your doctor.

Store Noltrexate-10 Tablet at room temperature.
Keep it away from direct sunlight and moisture.
Ensure the medicine is kept out of reach and sight of children.
Always check the expiry date before taking the medicine.

If you're managing rheumatoid arthritis with Noltrexate-10 Tablet, a balanced diet rich in fruits, vegetables, lean proteins, and whole grains can support your overall health.
As this medicine is used for psoriasis management, reducing alcohol consumption can help lower the chances of triggering a psoriasis flare-up.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Breast cancer, Rheumatoid arthritis, Psoriasis
Drug Category	Antimetabolite
Therapeutic Category	Antineoplastic

What is Noltrexate-10 Tablet used for?

This tablet is used to manage various types of cancers. It is also used to manage severe psoriasis (a skin disease with thickened patches of inflamed red skin, often covered by silvery scales) when other treatments are not effective, severe arthritis due to psoriasis, and rheumatoid arthritis (a disease that causes inflammation of the joints).

How does Noltrexate-10 Tablet work?

Noltrexate-10 Tablet works by interfering with the growth of rapidly dividing cells, such as those in autoimmune diseases or certain cancers. It reduces inflammation and suppresses the immune system to manage symptoms effectively.

Can I take Noltrexate-10 Tablet every day?

No, Noltrexate-10 Tablet is usually taken weekly, not daily, to avoid severe side effects. Always follow your doctor's prescribed schedule for safe and effective use.

What are the common side effects of Noltrexate-10 Tablet?

Common side effects include nausea, fatigue, nausea, vomiting, diarrhoea, dizziness, loss of appetite, and mild hair loss. Inform your doctor if these symptoms persist or worsen.

Is it safe to drive after taking Noltrexate-10 Tablet?

Noltrexate-10 Tablet may cause dizziness or drowsiness in some individuals. Avoid driving or operating heavy machinery until you know how the medication affects you.

Can I consume alcohol while taking Noltrexate-10 Tablet?

No, you should avoid alcohol, as it can increase the risk of liver damage when you're on this medication.

Can I take other medicines while on Noltrexate-10 Tablet?

Some medicines like ibuprofen and amoxicillin can interact with methotrexate; inform your doctor about all medications you're taking before starting this therapy.

Last Updated On 16 Aug. 2025 | 4:18PM (IST)

Certified Content

Written by

Dr. Divya Mandial

Medical Content Writer | 9 years

PhD in Chemistry

Reviewed by

Dr. Betina Chandolia

Lead Medical Content Reviewer | 10 years

BDS, MDS, PGCCL, PGDMH

Check out Editorial Policy

Manufacturer details

Zydus Tower, Satellite Cross Roads, Sarkhej - Gandhinagar Highway, Ahmedabad Ahmedabad GJ 380015 IN

Country of origin: INDIA

Expiry on or after: January 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Methotrexate: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00563
DailyMed - METHOTREXATE SODIUM tablet. (n.d.). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=89c05ea3-3be1-46dd-b112-29c436fd7289
FDA. (3879293). METHOTREXATE TABLETS, USP. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/008085s066lbl.pdf
Members bad.org.uk & Patient hub skinhealthinfo.org.uk. (n.d.). Patient Information leaflet: Methotrexate. https://www.skinhealthinfo.org.uk/wp-content/uploads/2018/11/Methotrexate-PIL-Feb-2024-1.pdf

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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