Listril Sm 2.5/5 MG Tablet 10

Torrent Pharmaceuticals Ltd.

Pack of 10 Units

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Composition

Lisinopril (5 Mg) + S-amlodipine (2.5 Mg)

Listril SM-2.5 Tablet is primarily used to manage high blood pressure, also known as hypertension, in adults. This medicine is a combination medicine that belongs to the class of medications known as angiotensin-converting enzyme (ACE) inhibitors and calcium channel blockers.

Aside from its main use, this medicine is beneficial when a single medication, either lisinopril or S-amlodipine, does not sufficiently control blood pressure. It serves to provide a synergistic effect, enhancing its blood pressure management properties.

Before you start taking this medicine, it is vital to consult your doctor regarding the correct dosage and frequency. It's crucial that you inform your doctor about any pre-existing conditions or ongoing medications. In case you notice any side effects while on this medicine, do inform your doctor right away. You should continue taking the medicine for the prescribed duration to achieve optimal results.

Listril SM-2.5 Tablet has the following uses:

Managing high blood pressure, also known as hypertension
Helping when a single medication is not enough to control high blood pressure

Here's how you should take Listril SM-2.5 Tablet:

Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet.
You can take it with or without food.
Always take the tablet at approximately the same time each day to maintain a consistent level in your body.
Never stop taking this medicine without consulting your doctor first; sudden discontinuation could lead to increased blood pressure.

Listril SM-2.5 Tablet is taken orally.

Listril SM-2.5 Tablet may have the following common side effects:

Headache
Dizziness
Fatigue
Nausea
Cough
Oedema: This is medical speak for swelling, typically occurring in the ankles or feet.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Listril SM-2.5 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea: If you're feeling sick after taking the tablet, consider having it with a meal.
Oedema: If swelling in your ankles or feet occurs, try taking this medicine in the morning to manage this effect better.

Listril SM-2.5 Tablet contains two active ingredients that work together to manage hypertension:

Lisinopril (5 mg): This ingredient acts as an ACE inhibitor. It inhibits the transformation of a hormone called angiotensin I into another hormone called angiotensin II, which is known to constrict blood vessels. As a result, your blood vessels relax, reducing blood pressure and decreasing the heart's workload.
S-Amlodipine (2.5 mg): This is a calcium channel blocker. It works by restricting the entry of calcium ions into the muscle cells of your heart and blood vessels. By doing so, it promotes the relaxation and dilution of blood vessels, which reduces peripheral vascular resistance, thereby managing high blood pressure.

Pregnancy

Listril SM-2.5 Tablet is contraindicated during pregnancy. If you are pregnant or planning to conceive, ensure to discuss this with your doctor before starting this medicine.

Breastfeeding

Listril SM-2.5 Tablet is contraindicated for breastfeeding women. Consult your doctor to understand the potential risks and benefits.

Alcohol

Caution is advised while consuming alcohol when taking Listril SM-2.5 Tablet as it may amplify the blood pressure-lowering effect of this medicine. Always consult your doctor for more information.

Liver

Caution is advised while taking Listril SM-2.5 Tablet in case of mild to moderate liver impairment. It's not recommended for severe liver diseases. If you have liver problems, discuss them with your doctor before starting this medicine.

Kidney

Caution is advised before using Listril SM-2.5 Tablet if you have a history of any kidney problems. It's a good idea to consult your doctor before taking this medicine.

Using Machines & Driving

As Listril SM-2.5 Tablet may cause dizziness, caution is advised when driving or operating heavy machinery until you know how this medicine affects you.

Allergy

If you are allergic to lisinopril or S-amlodipine or any other ingredients in Listril SM-2.5 Tablet, avoid using it and consult your doctor.

Children

Listril SM-2.5 Tablet isn't recommended for use in children under 18 years of age as its safety and effectiveness haven't been established in this age group.

Older Patients

Older patients should take Listril SM-2.5 Tablet under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age as they might also have liver and kidney issues and might be on other medication. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Listril SM-2.5 Tablet interacts with the following medicines:

Diuretics: Taking diuretics like furosemide or hydrochlorothiazide along with Listril SM-2.5 Tablet could enhance its blood pressure-lowering effects, potentially leading to hypotension.
Potassium supplements or potassium-sparing diuretics: Medicines like spironolactone or triamterene can increase the risk of hyperkalaemia (high potassium levels) when taken in combination with this medication.
NSAIDs: Medications such as ibuprofen or naproxen might reduce the blood pressure-lowering effect of this medicine.
Other antihypertensive medications: Using other blood pressure-lowering medicines like metoprolol or atenolol with Listril SM-2.5 Tablet might further lower your blood pressure, causing hypotension.

Drug-Food Interactions

There are no known significant food interactions with Listril SM-2.5 Tablet.

Drug-Disease Interactions

Listril SM-2.5 Tablet interacts with the following diseases:

Renal impairment: Due to the potential for increased medicinal levels and adverse effects, this medication should be used cautiously in patients suffering from kidney disease.
Hepatic impairment: Patients with liver disease may require careful monitoring and dosage adjustment while taking this medicine.
Diabetes: This medication can affect blood sugar levels, making it necessary to monitor glucose levels closely in diabetic patients.

Daily Dose

It's crucial to take the daily dose of Listril SM-2.5 Tablet as directed by your doctor. The dosage can vary based on individual factors like the severity of your condition and how well you respond to the medication. Always follow your doctor's prescribed dosage and never exceed it without consulting your doctor first.

Over Dose

Overdosing on Listril SM-2.5 Tablet may lead to more pronounced side effects such as dizziness, headache, or fatigue. If you suspect an overdose, don't panic but do inform your doctor about it.

Missed Dose

If you miss a dose of Listril SM-2.5 Tablet, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular dosing schedule. Never adjust your dosage without consulting your doctor first.

Store your Listril SM-2.5 Tablet at room temperature.
Keep it in a tightly closed container to protect it from light and moisture.
Always keep this medication out of reach of children for safety.
Ensure you use this medicine before its expiry date.

Since hypertension is managed by Listril SM-2.5 Tablet, lower your salt intake. Consuming less salt can help manage high blood pressure effectively.
Regular physical activity such as walking, cycling, or swimming can help in maintaining a healthy blood pressure level. Make sure to consult your doctor before starting any new exercise regimen.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Hypertension
Drug Category	ACE Inhibitor, Calcium Channel Blocker
Therapeutic Category	Antihypertensive

What is the basic function of Listril SM-2.5 Tablet?

It's primarily used to manage high blood pressure in adults by relaxing blood vessels, thus decreasing the heart's workload.

Can people with kidney problems use Listril SM-2.5 Tablet?

If you have renal issues, consult your doctor before taking this medicine, as caution is advised in such cases.

Is it safe for pregnant women to take Listril SM-2.5 Tablet?

Pregnant women, especially in their second and third trimesters, should avoid this medicine as it may harm the foetus.

Can I discontinue Listril SM-2.5 Tablet if my blood pressure becomes normal?

No, do not stop taking Listril SM-2.5 Tablet without consulting your doctor as it might lead to rebound hypertension.

What is the main component of Listril SM-2.5 Tablet?

Each tablet contains lisinopril (5 mg) and S-amlodipine (2.5 mg), both of which help in managing high blood pressure.

Are there any known side effects of Listril SM-2.5 Tablet?

Common side effects include headaches, dizziness, fatigue, nausea, coughing, and swelling in the ankles or feet.

How long does it take for Listril SM-2.5 Tablet to show its effect?

You may notice a decrease in blood pressure within a few days but full benefits are generally seen after 2-4 weeks.

Last Updated On 13 May. 2025 | 10:32AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Content Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Torrent House, Off. Ashram Road, Ahmedabad - 380009, Gujarat, India

Country of origin: INDIA

Expiry on or after: December 2025

In case of any issues, contact us:

support@truemeds.in|08069808861

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

AstraZeneca Pharmaceuticals LP. (2014). HIGHLIGHTS OF PRESCRIBING INFORMATION [Prescribing information]. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/019777s064lbl.pdf
Merck Sharp & Dohme Corp. (2016). HIGHLIGHTS OF PRESCRIBING INFORMATION. https://www.accessdata.fda.gov/drugsatfda_docs/label/2016/019558s060lbl.pdf
Lisinopril: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00722
Pfizer. (1987). NORVASC [Prescribing Information]. In NORVASC (pp. 1–7). https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/019787s047lbl.pdf
Amlodipine: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00381

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