Glura M Xr 1000 Tablet 15

Eris Lifesciences Ltd

Strip of 15 Units

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Old MRP ₹207.9

MRP ~~₹194.91~~

₹155.93

₹12.99/Units

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Prescription required for this medicine

Store Below 30^o C

Composition

Metformin (1000 Mg) + Sitagliptin (50 Mg)

Glura M Xr 1000 Tablet 15 is used to manage type 2 diabetes mellitus in adults when diet and exercise alone are not enough to control blood sugar levels. It is a combination medicine that belongs to the class of anti-diabetic medications.

This medicine helps improve glycaemic control by reducing both fasting and post-meal blood glucose concentrations. It enhances the body's sensitivity to insulin, allowing more effective glucose utilisation and decreasing glucose production by the liver.

You should take this medicine exactly as your doctor directs, who will determine the appropriate dosage based on your condition. Before starting this medicine, inform your doctor about any pre-existing health conditions or ongoing medications. If you notice any side effects while taking this medicine, inform your doctor immediately. Continue the medicine prescribed by your doctor for the full duration for optimal results.

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Glura M Xr 1000 Tablet 15 is used for the following:

Managing type 2 diabetes mellitus
Controlling blood sugar when diet and exercise aren't enough
Improving glycaemic control in adults
Reducing fasting blood glucose levels
Lowering after-meal blood sugar concentrations
Enhancing insulin sensitivity
Decreasing glucose production by the liver
Preventing diabetic retinopathy
Reducing the risk of diabetic nephropathy

Follow these instructions while taking Glura M Xr 1000 Tablet 15:

Swallow the tablet whole with a glass of water.
Do not crush, split, or chew the tablet.
Continue taking this medicine regularly as advised by your doctor.
Do not stop taking this medicine without consulting your doctor.

Glura M Xr 1000 Tablet 15 is taken orally.

Glura M Xr 1000 Tablet 15 may have the following common side effects:

Nausea
Vomiting
Diarrhoea
Abdominal discomfort
Headache
Hypoglycaemia: This occurs when your blood sugar drops too low, causing symptoms like shakiness, sweating, confusion, or dizziness.
Nasopharyngitis: This is inflammation of the nasal passages and the back of the throat, commonly known as a cold, causing symptoms like a runny nose and sore throat.
Upper respiratory tract infection: This refers to an infection affecting your nose, sinuses, or throat, typically causing symptoms like coughing, sneezing, and a sore throat.

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Glura M Xr 1000 Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor. Here are some general guidelines for managing common side effects:

Nausea and vomiting: Taking Glura M Xr 1000 Tablet 15 with meals can help reduce these digestive discomforts.
Abdominal discomfort: Try taking this medicine during or immediately after a meal to minimise stomach upset.

Glura M Xr 1000 Tablet 15 contains two active ingredients that work together to control blood sugar levels:

Sitagliptin (50 mg): This component inhibits an enzyme called dipeptidyl peptidase-4 (DPP-4), which normally breaks down incretin hormones in your body. By preventing this breakdown, sitagliptin increases the levels of incretins, which are natural substances that help lower blood sugar when it is high.
Metformin (1000 mg): This biguanide works by reducing glucose production in the liver. It also delays glucose absorption from the intestines and improves the body's sensitivity to insulin, allowing cells to take up glucose more effectively.

Pregnancy

Caution is advised while taking Glura M Xr 1000 Tablet 15 if you are pregnant. This medicine should only be used during pregnancy if the potential benefit to you justifies any potential risk to the baby. It is best to consult your doctor before taking this medicine.

Breastfeeding

Be careful while taking Glura M Xr 1000 Tablet 15 if you are breastfeeding. Your doctor may advise whether to discontinue breastfeeding or to stop using this medicine based on your specific situation.

Alcohol

Avoid consuming alcohol while taking Glura M Xr 1000 Tablet 15. Alcohol can increase the risk of developing lactic acidosis (a dangerous build-up of acid in your blood). It may affect how well your medicine works in controlling blood sugar levels.

Liver

Caution is advised while taking Glura M Xr 1000 Tablet 15 if you have liver problems. This medicine is not recommended for patients with severe liver disease. If you have a history of liver issues, inform your doctor before starting this medicine.

Kidney

Glura M Xr 1000 Tablet 15 is not recommended if you have kidney disease or kidney dysfunction. Your doctor should check your kidney function before starting this medicine and periodically during treatment.

Using Machines & Driving

You may drive and use machines while taking Glura M Xr 1000 Tablet 15 unless you experience side effects like dizziness or low blood sugar. If you notice these symptoms, avoid activities requiring alertness until you feel better.

Allergy

Do not take Glura M Xr 1000 Tablet 15 if you have ever had an allergic reaction to sitagliptin, metformin, or any other ingredients in this medicine. Tell your doctor about any previous allergic reactions to medicines.

Children

Glura M Xr 1000 Tablet 15 is not recommended for children under 18. This medicine has been specifically formulated to manage type 2 diabetes in adults. Consult your doctor for appropriate diabetes management options for children.

Older Patients

Older patients should take Glura M Xr 1000 Tablet 15 cautiously as they may have a decline in age-related kidney function. Your doctor may start with a lower dose and monitor you more closely.

Drug-Drug Interactions

Glura M Xr 1000 Tablet 15 interacts with the following medicines:

Cationic medicines: Medicines like digoxin, morphine, and vancomycin may interfere with metformin's action, reducing its effectiveness in controlling blood glucose.
Diuretics: Furosemide may alter the effectiveness of metformin in Glura M Xr 1000 Tablet 15, affecting your blood sugar control.
Calcium channel blockers: Nifedipine and similar medicines may increase blood glucose levels, potentially counteracting the glucose-lowering effect of Glura M Xr 1000 Tablet 15.
Insulin secretagogues: Medicines like glimepiride and glibenclamide, when taken with Glura M Xr 1000 Tablet 15, may increase the risk of hypoglycaemia (low blood sugar).

Drug-Disease Interactions

Glura M Xr 1000 Tablet 15 interacts with the following diseases:

Kidney disease: This medicine may accumulate in your body if you have impaired kidney function, increasing the risk of lactic acidosis (a dangerous build-up of acid in the blood).
Metabolic acidosis: Taking this medicine if you have this condition can worsen the acid imbalance in your body.
Liver disease: Your liver may not process this medicine properly, potentially increasing side effects.

Daily Dose

The daily dose of Glura M Xr 1000 Tablet 15 should be taken as prescribed by your doctor. Your dosage may change based on your individual response and condition severity.

Over Dose

Taking more than the prescribed dosage of Glura M Xr 1000 Tablet 15 may cause nausea, vomiting, stomach discomfort, headache, and low blood sugar (hypoglycaemia). If you experience these symptoms, consult your doctor for guidance.

Missed Dose

If you forget to take Glura M Xr 1000 Tablet 15, take it as soon as you remember. If it's nearly time for your next dose, skip the missed dose and continue your regular schedule. Never double your dose.

Store Glura M Xr 1000 Tablet 15 below 30°C.
Keep away from direct sunlight and moisture.
Ensure the medicine remains out of reach of children.
Check the expiry date before use and discard any expired tablets.
Do not remove tablets from their original packaging until needed.

Monitor your carbohydrate intake by choosing complex carbohydrates (whole grains, vegetables) over simple sugars to help maintain stable blood glucose levels throughout the day.
Engage in regular moderate physical activity (like brisk walking for 30 minutes daily) to improve your body's insulin sensitivity and help manage your blood sugar levels.

Fact Box

Available Dosage Types	Tablet ER
Habit Forming	No
Ailment	Type 2 diabetes, Hyperglycaemia, Insulin resistance
Drug Category	DPP-4 inhibitor, Biguanide
Therapeutic Category	Anti-diabetic medication

Can Glura M Xr 1000 Tablet 15 be used for type 1 diabetes?

No. This medicine is only for adults with type 2 diabetes. Type 1 diabetes requires different treatment, typically including insulin.

What should I do if I miss a dose?

Take it as soon as you remember. If it's nearly time for your next dose, skip the missed one. Never take a double dose to make up.

Can I drink alcohol while taking this medicine?

No. Alcohol can increase your risk of lactic acidosis (harmful acid build-up in your blood) and low blood sugar when taking this medicine.

How should I store Glura M Xr 1000 Tablet 15?

Store below 30°C in a tightly closed container away from direct sunlight and moisture. Keep out of children's reach.

What are the common side effects of this medicine?

Common side effects include stomach discomfort, nausea, diarrhoea, headache, and upper respiratory infections. Most improve as your body adjusts to the medicine.

Should I take Glura M Xr 1000 Tablet 15 with or without food?

Take this medicine with meals. Taking it with food helps reduce stomach-related side effects and helps your body use the medicine better.

What should I tell my doctor before starting this medicine?

Inform your doctor about kidney problems, liver issues, allergies, pregnancy plans, alcohol consumption habits, and all other medicines you're currently taking.

Last Updated On 20 May. 2025 | 4:53PM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Meenakshi Maruwada

Medical Content Writer | 9 years

BDS, PGCAD, GMHE (IIM-B)

Check out Editorial Policy

Manufacturer details

Shivarth Ambit, Plot No. 142/2, Ramdas Road, Off SBR, Near Swati Bungalows, Ahmedabad, Gujarat - 380054

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Sitagliptin and Metformin hydrochloride [Product Monograph]. (2017). Merck Canada Inc. https://pdf.hres.ca/dpd_pm/00038451.PDF
Sitagliptin and metformin hydrochloride [Prescribing Information]. (2023). Merck Sharp & Dohme LLC. https://www.merck.com/product/usa/pi_circulars/j/januvia/januvia_pi.pdf
Metformin: MedlinePlus drug information. (n.d.). MedlinePlus - Health Information from the National Library of Medicine. https://medlineplus.gov/druginfo/meds/a696005.html
Metformin - StatPearls - NCBI bookshelf. (2023, August 17). National Center for Biotechnology Information. https://www.ncbi.nlm.nih.gov/books/NBK518983/

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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CIN: U62099MH2019PTC320566

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