Gluconorm Z Xr Forte 60 Tablet 10

Lupin Ltd

Strip of 10 Units

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Old MRP ₹115.55

MRP ~~₹108.33~~

₹86.66

₹10.83/Units

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Composition

Gliclazide (60 Mg) + Metformin (1000 Mg)

Gluconorm Z Xr Forte 60 Tablet 10 is used to manage high blood sugar levels in adults with type 2 diabetes mellitus. It is a combination medicine that belongs to the class of antidiabetic medications, specifically designed for patients whose blood sugar cannot be controlled by diet, exercise, or single-agent therapy alone.

This medicine helps when your body doesn't produce enough insulin or cannot use insulin effectively. It works by addressing both insulin deficiency and insulin resistance, providing comprehensive control of your blood glucose levels throughout the day, particularly after meals.

This medicine should be taken orally exactly as prescribed by your doctor. Before starting this medicine, inform your doctor about any pre-existing conditions you may have or any other medicines you are currently taking. If you notice any side effects while using this medicine, notify your doctor promptly. Continue taking the medicine for the full duration prescribed by your doctor for optimal results.

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Gluconorm Z Xr Forte 60 Tablet 10 is used for the following:

Management of type 2 diabetes mellitus in adults
Control of blood sugar when diet and exercise fail
Regulation of glucose levels after single-agent therapy inadequacy
Improvement of glycaemic control in diabetic patients
Dual action treatment for insulin deficiency and resistance
Comprehensive management of blood glucose metabolism
Long-term blood sugar control in adults with diabetes
Prevention of diabetes-related complications
Stabilisation of blood sugar throughout the day
Maintenance therapy for persistent hyperglycaemia (high blood sugar)

Follow these instructions while taking Gluconorm Z Xr Forte 60 Tablet 10:

Swallow the tablet whole with a full glass of water.
Take this medicine with food, preferably with breakfast or your first main meal.
Avoid crushing, chewing, or breaking the tablet as this affects its extended-release action.
Take at the same time each day to maintain consistent blood levels.
Continue taking this medicine regularly as prescribed by your doctor.
Keep following your recommended diet and exercise programme.
Consult your doctor if you have questions about taking this medicine.

Gluconorm Z Xr Forte 60 Tablet 10 is taken orally.

Gluconorm Z Xr Forte 60 Tablet 10 may have the following common side effects:

Hypoglycaemia: This refers to low blood sugar levels, which may cause sweating, trembling, confusion, and rapid heartbeat.
Nausea
Vomiting
Diarrhoea
Abdominal pain
Metallic taste in the mouth: You might experience an unusual metallic flavour when eating or drinking.
Headache
Dizziness
Weight changes

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Gluconorm Z Xr Forte 60 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Nausea and vomiting: Taking this medicine with food can help reduce these stomach-related side effects.
Metallic taste in mouth: Taking Gluconorm Z Xr Forte 60 Tablet 10 with breakfast or your first main meal of the day may help minimise this effect.

Gluconorm Z Xr Forte 60 Tablet 10 contains two active ingredients that work together to control blood sugar levels:

Gliclazide (60 mg): This component stimulates insulin secretion from the pancreas. It binds to specific receptors on the beta cells in your pancreas, triggering the release of insulin, which helps lower your blood glucose levels, especially after meals.
Metformin (1000 mg): This medication works through multiple mechanisms to control blood sugar levels. It decreases glucose production by the liver, reducing the amount of sugar released into your bloodstream. It also reduces intestinal glucose absorption, limiting how much sugar enters your bloodstream from food. Additionally, it enhances peripheral glucose uptake by improving insulin sensitivity, helping your body cells use available insulin more effectively.

Pregnancy

Gluconorm Z Xr Forte 60 Tablet 10 is generally not recommended during pregnancy. If you are pregnant or planning to conceive, make sure to discuss this with your doctor before starting this medicine. Insulin is usually the preferred option for managing diabetes during pregnancy.

Breastfeeding

Gluconorm Z Xr Forte 60 Tablet 10 is contraindicated for breastfeeding women. Both active ingredients may pass into breast milk. Consult your doctor to understand the potential risks and benefits, and to discuss alternative options for diabetes management during this period.

Alcohol

Avoid alcohol consumption while taking Gluconorm Z Xr Forte 60 Tablet 10. Alcohol increases the risk of lactic acidosis (a rare but serious condition with symptoms like unusual muscle pain and breathing difficulties). It can enhance the blood sugar-lowering effect of this medicine, potentially causing dangerously low blood sugar levels.

Liver

Doctor consultation is advised while taking Gluconorm Z Xr Forte 60 Tablet 10 if you have liver problems. This medicine is contraindicated in severe liver dysfunction. The medicine's components may affect how your liver processes substances, potentially increasing the risk of side effects.

Kidney

Gluconorm Z Xr Forte 60 Tablet 10 is contraindicated in severe kidney impairment or kidney disease. Your kidneys help remove this medicine from your body. If you have any kidney problems, even mild ones, inform your doctor before taking this medicine, as dose adjustments or alternative treatments may be necessary.

Using Machines & Driving

Exercise caution when driving or operating machinery while taking Gluconorm Z Xr Forte 60 Tablet 10. This medicine may cause low blood sugar (hypoglycaemia), which can lead to dizziness, confusion, or blurred vision. If you experience these symptoms, avoid potentially dangerous activities until you feel better.

Allergy

If you have a known hypersensitivity to gliclazide, metformin, or sulphonylureas (a class of diabetes medicines), avoid taking Gluconorm Z Xr Forte 60 Tablet 10. Tell your doctor about any previous allergic reactions to medicines. Watch for signs of an allergic reaction such as skin rash, itching, or swelling.

Children

Gluconorm Z Xr Forte 60 Tablet 10 is not recommended for children and adolescents under 18 years of age. The safety and effectiveness of this medicine have not been established in this age group. Type 2 diabetes in children requires specific management approaches that your doctor can advise on.

Older Patients

Older patients should take Gluconorm Z Xr Forte 60 Tablet 10 under close medical supervision. Your doctor will start with lower doses as elderly patients may be more susceptible to side effects, particularly hypoglycaemia. Regular monitoring of kidney function is essential. Older patients might also have other health conditions or be taking additional medicines that could interact with this treatment.

Drug-Drug Interactions

Gluconorm Z Xr Forte 60 Tablet 10 interacts with the following medicines:

Beta-blockers: Medicines such as propranolol and atenolol may mask symptoms of hypoglycemia (low blood sugar), making it difficult to recognise when your blood glucose drops too low.
Corticosteroids: Medicines such as prednisolone and dexamethasone can elevate your blood glucose levels, potentially reducing the effectiveness of Gluconorm Z Xr Forte 60 Tablet 10.
ACE inhibitors: Medicines such as enalapril and ramipril may enhance the glucose-lowering effects of this medicine, potentially increasing the risk of hypoglycemia.
NSAIDs: Medicines such as ibuprofen and diclofenac can potentiate the hypoglycemic effects of gliclazide, increasing the risk of low blood sugar.
Diuretics: Medicines such as furosemide and hydrochlorothiazide may affect glycemic control and alter the effectiveness of metformin.

Drug-Food Interactions

Gluconorm Z Xr Forte 60 Tablet 10 interacts with the following foods:

High-fibre foods: May slightly reduce the absorption of metformin.
Grapefruit: May affect the metabolism of gliclazide, potentially altering its effectiveness.

Drug-Disease Interactions

Gluconorm Z Xr Forte 60 Tablet 10 interacts with the following diseases:

Acute conditions causing tissue hypoxia: Conditions such as heart attack, severe infection, or respiratory failure increase the risk of lactic acidosis when taking this medicine.

Daily Dose

The daily dose of Gluconorm Z Xr Forte 60 Tablet 10 should be taken exactly as prescribed by your doctor. Your dosage may vary based on your blood sugar levels and how well you respond to treatment. Never change your dose without consulting your doctor.

Over Dose

Taking too much of this medicine may cause low blood sugar (hypoglycaemia), stomach discomfort, nausea, or vomiting. You might feel dizzy, confused, or exhausted. Contact your doctor if you suspect an overdose has occurred.

Missed Dose

If you forget to take your tablet, take it with your next meal if you remember on the same day. If a whole day has passed, skip the missed dose and continue your regular schedule. Never take two doses together.

Store Gluconorm Z Xr Forte 60 Tablet 10 at room temperature (below 30°C).
Keep it in its original packaging to protect it from direct sunlight and moisture.
Avoid storing in bathrooms due to humidity.
Keep out of reach of children.
Do not use the medicine after its expiry date.
Store away from excessive heat sources.

Maintain consistent carbohydrate intake across meals to help prevent blood sugar fluctuations. Try to eat regular meals with similar amounts of carbohydrates each day to support stable glucose levels.
Include 30 minutes of moderate physical activity (like brisk walking) most days of the week to improve your body's insulin sensitivity and help lower blood glucose levels.

Fact Box

Available Dosage Types	Extended-release Tablet
Habit Forming	No
Ailment	Type 2 diabetes mellitus
Drug Category	Insulin secretagogue plus insulin sensitiser
Therapeutic Category	Antidiabetic combination

Can I stop taking Gluconorm Z Xr Forte 60 Tablet 10 if my blood sugar levels become normal?

Continue taking it as prescribed. Stopping suddenly can cause dangerous blood sugar spikes and worsen your diabetes.

What should I do if I miss a dose?

Take it as soon as you remember, unless it's nearly time for your next dose. Never double-dose to make up for a missed tablet.

Can I consume alcohol while taking this medicine?

Avoid alcohol completely. It increases your risk of lactic acidosis (dangerous acid buildup) and can cause severe low blood sugar.

Is regular blood testing necessary while taking this medicine?

Yes, regular monitoring of blood glucose, HbA1c, kidney function and vitamin B12 levels is essential for safe and effective treatment.

How should I store Gluconorm Z Xr Forte 60 Tablet 10?

Store at room temperature (below 30°C) in its original packaging, away from moisture, direct sunlight, and out of the reach of children.

Can I take this medicine during pregnancy?

This medicine is generally not recommended during pregnancy. Insulin is usually preferred for managing diabetes during pregnancy.

What are the signs of hypoglycaemia (low blood sugar) to watch for?

Watch for symptoms such as sweating, trembling, confusion, dizziness, hunger, a fast heartbeat, and blurred vision. Always carry quick-acting glucose sources.

Last Updated On 25 Sep. 2025 | 7:59AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Panacea Biotec Limited. (2019). PRODUCT MONOGRAPH GLIZID-M gliclazide 80mg and Metformin 500mg. https://media.panaceabiotec.com/documents/2019/7/27/ProductMonograph-GlizidM-GliclazideplusMetformin.pdf
Gliclazide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01120
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Polavarapu, N. K., Kale, R., Sethi, B., Sahay, R. K., Phadke, U., Ramakrishnan, S., Mane, A., Mehta, S., & Shah, S. (2020). Effect of Gliclazide or Gliclazide plus Metformin Combination on Glycemic Control in Patients with T2DM in India: A Real-World, Retrospective, Longitudinal, Observational Study from Electronic Medical Records. Drugs - Real World Outcomes, 7(4), 271–279. https://doi.org/10.1007/s40801-020-00206-7
Alsharidah, M., Algeffari, M., Abdel-Moneim, A. H., Lutfi, M. F., & Alshelowi, H. (2018). Effect of combined gliclazide/metformin treatment on oxidative stress, lipid profile, and hepatorenal functions in type 2 diabetic patients. Saudi Pharmaceutical Journal, 26(1), 1–6. https://doi.org/10.1016/j.jsps.2017.11.007

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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