Glador M2 Tablet 15

Lupin Ltd

Strip of 15 Units

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Old MRP ₹317.1

MRP ~~₹297.28~~

₹252.69

₹19.82/Units

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

Glador M2 Tablet is primarily used to manage type 2 diabetes in adults. This medication is a combination medicine and belongs to a group of medicines known as oral antidiabetics.

Besides the main purpose, this tablet is also utilised to reduce the risk of long-term complications associated with diabetes, such as kidney damage, blindness, nerve problems, limb amputations, and cardiovascular disease.

This medicine should be taken orally as directed by your doctor. Inform your doctor about any pre-existing conditions or ongoing medications before starting this medication. If you notice any side effects while on this medicine, notify your doctor immediately. Continue taking the tablet for the duration prescribed by your doctor for optimal results.

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Here's how you should take Glador M2 Tablet:

Swallow the tablet whole with a glass of water during your meal.
Do not crush, chew or split the tablet.
Consult your doctor if you feel the need to adjust your daily dose.
Continue taking this medicine as long as your doctor advises; do not stop without their guidance.

Glador M2 Tablet is taken orally.

While using Glador M2 Tablet, you may experience some of the following side effects:

Diarrhoea
Nausea and vomiting
Flatulence: This refers to excessive gas in the stomach or intestines, commonly known as 'passing wind' or 'farting'.
Asthenia: This means feeling weak or lacking energy.
Indigestion
Abdominal discomfort
Headache

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Glador M2 Tablet. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some tips to manage a few common side effects:

Diarrhoea: You can try taking Glador M2 Tablet with a meal.
Indigestion: Consider taking this medicine after meals to lessen this effect.

Glador M2 Tablet contains two active ingredients that work together to manage blood glucose levels:

Glimepiride (2 mg): This ingredient belongs to a class of medicines known as sulfonylureas. It works by stimulating insulin secretion from the pancreas. Insulin is a hormone that helps regulate blood sugar levels.
Metformin (500 mg): Classified as a biguanide, metformin performs three key activities in your body. Firstly, it decreases the amount of glucose produced by your liver. Secondly, it reduces the amount of glucose absorbed by your intestines from food. Lastly, it improves insulin sensitivity in your body's cells thereby enhancing their ability to utilise glucose.

By combining these two ingredients, Glador M2 Tablet effectively manages blood glucose levels in patients suffering from type 2 diabetes.

Pregnancy

This medicine should be used with caution if you're pregnant. Poorly controlled diabetes can pose risks to both mother and baby. If Glador M2 Tablet alone cannot maintain good blood sugar control, your doctor may suggest switching to insulin.

Breastfeeding

Glador M2 Tablet isn't recommended if you're nursing. Metformin, one of the active ingredients, is known to pass into breast milk. It's best to consult your doctor before taking this medicine while breastfeeding.

Alcohol

Excessive alcohol intake should be avoided when taking Glador M2 Tablet. Alcohol can increase the effect of metformin on lactate metabolism, which could lead to lactic acidosis - a potentially serious condition.

Liver

If you have liver problems, you should proceed with caution when taking Glador M2 Tablet. This medication may impact liver function, thus it's advisable to discuss any liver-related concerns with your doctor before starting this medicine.

Kidney

Glador M2 Tablet isn't recommended for those with severe kidney impairment. Prior to starting Glador M2 Tablet, it's crucial that your kidney function is assessed by your doctor.

Using Machines & Driving

Glador M2 Tablet shouldn't affect your ability to drive or operate machinery. However, if you experience any side effects such as dizziness or blurred vision, avoid these activities and promptly consult your doctor.

Allergy

If you have known hypersensitivity to glimepiride, metformin or any other components of Glador M2 Tablet, avoid using this medicine. Always inform your doctor about any allergies before starting a new medication.

Children

Glador M2 Tablet shouldn't be given to children under 18 years old as its safety and effectiveness in this age group haven't been established.

Older Patients

Older patients, especially those above 80 years, should use Glador M2 Tablet under medical supervision. They may be more susceptible to side effects such as hypoglycemia and gastrointestinal issues. Regular checks of kidney function are advised for these patients.

Drug-Drug Interactions

Glador M2 Tablet interacts with the following medicines:

Diuretics: Medicines like furosemide or hydrochlorothiazide can increase the risk of lactic acidosis when taken with Glador M2 Tablet, due to their potential to impair renal function.
Corticosteroids: These medications, such as prednisone or dexamethasone, can alter glucose metabolism. This may require dosage adjustment of Glador M2 Tablet.
Beta-blockers: Medicines like propranolol or metoprolol may mask signs of low blood sugar (hypoglycaemia), a potential side effect of Glador M2 Tablet.
ACE inhibitors: Medications like lisinopril or enalapril may increase the risk of hypoglycaemia when used concurrently with Glador M2 Tablet.

Drug-Food Interactions

Glador M2 Tablet does not have any known specific interactions with food. However, it should be taken with meals to reduce gastrointestinal side effects.

Drug-Disease Interactions

Glador M2 Tablet interacts with the following diseases:

Renal Impairment: People with severe kidney disease should not take this medication due to increased risk of lactic acidosis.
Hepatic Impairment: Liver disease may increase the risk of lactic acidosis, so caution is advised when using Glador M2 Tablet.
Heart Failure: Patients with congestive heart failure requiring treatment should use this medicine with caution due to the risk of lactic acidosis.

Daily Dose

Your doctor will prescribe the appropriate daily dose of Glador M2 Tablet, considering factors such as your health condition and how you respond to the medicine. It's vital to stick to the prescribed dosage and never exceed it without consulting your doctor.

Over Dose

Overdosing on Glador M2 Tablet may result in symptoms like dizziness, excessive sweating, or shaking. If you accidentally take too much, don’t panic but do inform your doctor to avoid any potential complications.

Missed Dose

If a dose of Glador M2 Tablet is missed, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Never double up on doses without asking your doctor.

Store Glador M2 Tablet at room temperature, ideally below 30°C.
Avoid exposing the medication to extreme temperatures, excess light or moisture.
Always keep out of reach of children for their safety.
Ensure you use this medicine before its expiry date.

Since Glador M2 Tablet helps manage type 2 diabetes, incorporate foods with a low glycaemic index like whole grains and leafy vegetables into your diet.
Regular physical activity is crucial; aim for at least 30 minutes of moderate exercise such as walking or cycling daily, which can help maintain blood glucose levels.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 Diabetes
Drug Category	Insulin Secretagogue, Anti-hyperglycemic
Therapeutic Category	Antidiabetic

What is Glador M2 Tablet used for?

Glador M2 Tablet is a medicine used to manage type 2 diabetes in adults, helping to improve blood sugar control.

How does Glador M2 Tablet work?

This medicine combines glimepiride and metformin. Glimepiride stimulates insulin release from the pancreas, while metformin reduces glucose production and absorption.

How should I take Glador M2 Tablet?

Take Glador M2 Tablet orally once daily with meals. Do not crush, chew, or split the tablet; swallow it whole.

Can I take this medicine if I have kidney problems?

Severe kidney impairment contraindicates use of Glador M2 Tablet. If you have mild to moderate impairment, consult your doctor first.

What are the potential side effects of Glador M2 Tablet?

Common side effects include diarrhoea, nausea, flatulence, weakness, indigestion, abdominal discomfort, and headache. Serious side effects may include lactic acidosis and hypoglycaemia.

Can I drink alcohol while taking Glador M2 Tablet?

You should avoid excessive alcohol intake while using this medicine as it can increase the risk of lactic acidosis.

Can pregnant or breastfeeding women take Glador M2 Tablet?

If you're pregnant or breastfeeding, consult your doctor before using Glador M2 Tablet.

Last Updated On 13 May. 2025 | 10:30AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 13 years

MSc (Applied Genetics)

Reviewed by

Dr. Chhavi Rosha

Medical Content Writer | 9 years

BAMS, FMC, MD Resident

Check out Editorial Policy

Manufacturer details

Kalpataru Inspire, 3rd Floor, Off. Western Express Highway, Santacruz (East), Mumbai

Country of origin: INDIA

Expiry on or after: February 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

Unknown. (n.d.). Metformin hydrochloride Prolonged Release & Glimepiride tablets I.P. [Pharmaceutical Information]. https://www.sanofi.in/dam/jcr:6c1f15ea-d4af-4e93-b38c-91a76293b247/Amaryl%20M%20-%20PI.pdf
Unknown. (2022). GLUCOPHAGE. https://www.accessdata.fda.gov/drugsatfda_docs/label/2017/020357s037s039,021202s021s023lbl.pdf
AMARYL. (n.d.). AMARYL (glimepiride tablets) 1, 2, and 4 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
Metformin: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00331
Glimepiride: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB00222

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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