Endoformin G 2/500 MG Tablet 10

Q: What is Endoformin G 2/500 MG Tablet 10 used for?

Endoformin G 2/500 MG Tablet 10 is prescribed to manage type 2 diabetes in adults, thereby improving control over blood glucose levels.

Q: How does Endoformin G 2/500 MG Tablet 10 work?

It works by combining its two active ingredients, glimepiride and metformin, which together reduce blood glucose levels by stimulating insulin release and decreasing glucose production.

Q: Can I chew or crush Endoformin G 2/500 MG Tablet 10 before taking it?

No, you should swallow the whole tablet with water. Chewing or crushing it could affect the medicine's effectiveness.

Q: What are the common side effects of Endoformin G 2/500 MG Tablet 10?

Common side effects include hypoglycaemia, diarrhoea, nausea, vomiting, abdominal pain, and headache. Consult your doctor if these persist.

Q: Can I drink alcohol while taking Endoformin G 2/500 MG Tablet 10?

Avoid excessive alcohol consumption as it may interfere with the effectiveness of the medicine and could increase your risk of lactic acidosis.

Q: Can Endoformin G 2/500 MG Tablet 10 be used during pregnancy or breastfeeding?

The use of this medicine during pregnancy or breastfeeding should only be considered after consulting with your doctor if its benefits outweigh potential risks.

Q: How should I store my Endoformin G 2/500 MG Tablet 10?

Store your tablets below 25°C in a dry place, away from light and moisture, and out of reach of children.

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Composition

Glimepiride (2 Mg) + Metformin (500 Mg)

Endoformin G 2/500 MG Tablet 10 is used to manage type 2 diabetes by controlling blood sugar levels. It combines metformin (500 mg) and glimepiride (2 mg) to improve insulin sensitivity and increase insulin production. Regular blood sugar monitoring is recommended while using this medication.

This medicine also effectively controls high blood glucose levels in adults, whereas metformin alone doesn't adequately control it.

Before starting this tablet, consult your doctor for guidance on the correct dosage and frequency. Inform them about existing medical conditions and medications, if any. If you notice any side effects while taking this medicine, immediately notify them. Remember to continue the medication for the duration prescribed by your doctor for optimal results.

Endoformin G 2/500 MG Tablet 10 is used for the following:

Improving blood sugar control in adults with type 2 diabetes
Effectively managing type 2 diabetes when diet and exercise alone are insufficient
When blood sugar levels are not adequately controlled by metformin alone
For patients already being treated with separate glimepiride and metformin tablets

Directions for Use of Endoformin G 2/500 MG Tablet 10

Follow these instructions while taking Endoformin G 2/500 MG Tablet 10:

Swallow the whole tablet with a glass of water.
Avoid crushing or chewing the tablet.
Take the tablet as instructed by your doctor.
Do not alter the dose without consulting your doctor first.
Remember to never abruptly stop taking this medicine without discussing it with your doctor.

Endoformin G 2/500 MG Tablet 10 is taken orally.

Side Effects of Endoformin G 2/500 MG Tablet 10

Using Endoformin G 2/500 MG Tablet 10 may cause the following side effects:

Hypoglycaemia
Diarrhoea
Nausea
Vomiting
Abdominal pain
Headache

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Endoformin G 2/500 MG Tablet 10. However, if you experience serious side effects or worsening symptoms, consult your doctor.

Here are some guidelines for managing common side effects:

Hypoglycaemia: If you feel shaky, dizzy, or hungry after taking this medicine, try to eat a small meal or snack.
Diarrhoea: Try taking this tablet with your evening meal to lessen this effect.

How Endoformin G 2/500 MG Tablet 10 Works?

Endoformin G 2/500 MG Tablet 10 contains two active ingredients:

Glimepiride (2 mg): This component binds to receptors on pancreatic beta cells, leading to a series of cellular reactions that stimulate insulin secretion, a hormone that helps lower glucose levels in your blood.
Metformin (500 mg): Metformin reduces glucose production in the liver, decreases glucose absorption from the intestines, and improves insulin sensitivity in the muscles and fat tissues. This triadic action effectively lowers blood sugar levels.

Pregnancy

If you are pregnant, caution is recommended while taking Endoformin G 2/500 MG Tablet 10. Before starting this medicine, discuss its risks and benefits with your doctor.

Breastfeeding

If you're breastfeeding, consult your doctor before starting this medicine to discuss the importance of Endoformin G 2/500 MG Tablet 10 and its potential risks.

Alcohol

Avoid excessive alcohol intake while using Endoformin G 2/500 MG Tablet 10 as it may interfere with the medication's effectiveness and increase the risk of side effects.

Liver

If you have liver health issues, discuss them with your doctor before starting Endoformin G 2/500 MG Tablet 10. Your doctor will guide you based on your health status.

Kidney

Endoformin G 2/500 MG Tablet 10 is not recommended for use if you have severe kidney issues. Consult your doctor before using this medicine if you have a history of kidney problems.

Using Machines & Driving

This medicine may cause dizziness or blurred vision, which can affect the ability to drive or operate machinery. Avoid such activities if you experience these symptoms.

Allergy

Avoid taking Endoformin G 2/500 MG Tablet 10 if you're allergic to glimepiride, metformin, or any of its other ingredients.

Children

Endoformin G 2/500 MG Tablet 10 is not recommended for use in children below 18 years of age. Always consult your doctor before giving any medicine to a child.

Older Patients

Extra care should be taken when using Endoformin G 2/500 MG Tablet 10 for older patients, as they may be more susceptible to its side effects. Consider age-related decreases in renal function and concomitant disease or medication therapy. Your doctor will guide you based on your health status.

Interactions of Endoformin G 2/500 MG Tablet 10

Drug-Drug Interactions

Endoformin G 2/500 MG Tablet 10 interacts with the following medicines:

CYP2C9 inhibitors: Medicines like fluconazole and amiodarone may increase the levels of glimepiride in your body, making you more susceptible to side effects like hypoglycaemia.
Other glucose-lowering medications: If you're taking salicylates, sulphonamides, chloramphenicol, probenecid, or cimetidine, these can intensify the glucose-lowering effect of glimepiride resulting in low blood sugar levels.
Cationic medications: These medicines, including amiloride, digoxin, morphine, procainamide, quinidine, ranitidine, triamterene, trimethoprim, and vancomycin, may reduce how quickly your body eliminates metformin, which could increase its action and side effects.

Drug-Food Interactions

Endoformin G 2/500 MG Tablet 10 has known interactions with certain foods:

High-fibre foods: These can slow down the absorption of metformin into your bloodstream. This may alter the effectiveness of this medicine.

Drug-Disease Interactions

Endoformin G 2/500 MG Tablet 10 interacts with the following diseases:

Renal impairment: If you have severe kidney problems (eGFR <30 mL/min/1.73m²), this medicine is not recommended because it might accumulate in your body.
Congestive heart failure: If you're suffering from heart failure requiring pharmacological treatment, this medication could worsen your condition.
Metabolic acidosis: If you're suffering from acute or chronic metabolic acidosis (including diabetic ketoacidosis), this medicine is contraindicated as it can exacerbate the condition.

Dosage of Endoformin G 2/500 MG Tablet 10

Daily Dose

Your doctor will determine the daily dose of Endoformin G 2/500 MG Tablet 10 based on your specific needs. Follow the prescribed dosage and never alter it without consulting your doctor.

Over Dose

If you accidentally take more Endoformin G 2/500 MG Tablet 10 than recommended, you might experience symptoms like low blood sugar. If this happens, contact your doctor immediately.

Missed Dose

If you miss a dose, take it as soon as you remember. But if it's nearly time for the next dose, skip the missed one and continue with your schedule.

Store Endoformin G 2/500 MG Tablet 10 at a cool temperature below 25°C.
Keep it in a dry place, shielding it from light and moisture.
Ensure it is out of reach of children for safety reasons.
Always check the expiry date before use to ensure the medicine's effectiveness.

Maintain a balanced diet low in sugars and high in fibre to help control blood sugar levels, which is crucial when managing type 2 diabetes.
Regular physical activity, such as walking or cycling, can help improve insulin sensitivity and better manage your blood sugar levels.

Fact Box

Drug Category	Insulin secretagogue, Biguanide
Therapeutic Category	Antidiabetic
Available Dosage Types	Tablet
Habit Forming	No
Ailment	Type 2 diabetes mellitus

What is Endoformin G 2/500 MG Tablet 10 used for?

Endoformin G 2/500 MG Tablet 10 is prescribed to manage type 2 diabetes in adults, thereby improving control over blood glucose levels.

How does Endoformin G 2/500 MG Tablet 10 work?

It works by combining its two active ingredients, glimepiride and metformin, which together reduce blood glucose levels by stimulating insulin release and decreasing glucose production.

Can I chew or crush Endoformin G 2/500 MG Tablet 10 before taking it?

No, you should swallow the whole tablet with water. Chewing or crushing it could affect the medicine's effectiveness.

What are the common side effects of Endoformin G 2/500 MG Tablet 10?

Common side effects include hypoglycaemia, diarrhoea, nausea, vomiting, abdominal pain, and headache. Consult your doctor if these persist.

Can I drink alcohol while taking Endoformin G 2/500 MG Tablet 10?

Avoid excessive alcohol consumption as it may interfere with the effectiveness of the medicine and could increase your risk of lactic acidosis.

Can Endoformin G 2/500 MG Tablet 10 be used during pregnancy or breastfeeding?

The use of this medicine during pregnancy or breastfeeding should only be considered after consulting with your doctor if its benefits outweigh potential risks.

How should I store my Endoformin G 2/500 MG Tablet 10?

Store your tablets below 25°C in a dry place, away from light and moisture, and out of reach of children.

Last Updated On 30 Apr. 2025 | 9:14AM (IST)

Certified Content

Written by

Dr Nikita Lobo

Medical Editor & Reviewer | 8 years

BDS, MDS

Reviewed by

Dr. Saniya K Mulla

Medical Writer & Reviewer | 6 years

MBBS

Check out Editorial Policy

Manufacturer details

Wonder Mall, 316, Orion Business Park, Near, Ghodbunder Rd, Thane, Maharashtra 400606

Country of origin: INDIA

References

DailyMed. (n.d.). Amaryl- glimepiride tablet. U.S. National Library of Medicine. Retrieved 1 April 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=b857eccf-b9ff-45ba-8241-f47f5caada2a
Langtry HD, Balfour JA. Glimepiride. A review of its use in the management of type 2 diabetes mellitus. Drugs. 1998;55(4):563-584. https://pubmed.ncbi.nlm.nih.gov/9561345/
Food and Drug Administration. (n.d.). Full prescribing information: Amaryl. Retrieved 1 April 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2009/020496s021lbl.pdf
DrugBank. (n.d.). Metformin. Retrieved April 1, 2024, from https://go.drugbank.com/drugs/DB00331

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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