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Extacef Tazo 1125Mg Injection 1

Blue Cross Laboratories Ltd

Vial of 1 UNITS

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Composition

Ceftriaxone (1000 Mg) + Tazobactam (125 Mg)

Extacef Tazo 1125mg Injection 1 is used to treat severe bacterial infections affecting the lungs, skin, urinary tract, and abdomen. This combination of third-generation cephalosporin antibiotics and beta-lactamase inhibitors works by eliminating infection-causing bacteria and preventing their growth. It helps manage complicated infections and improve recovery from bacterial diseases.

Before starting this medicine, it's crucial to consult your doctor for the correct dosage and frequency. Inform your doctor about any pre-existing health conditions or ongoing medications. If you experience any side effects while on this medication, inform your doctor immediately. Continue the treatment for the prescribed duration to ensure optimal results.

Extacef Tazo 1125mg Injection 1 is used to manage complicated intra-abdominal infections, complicated urinary tract infections such as pyelonephritis, hospital-acquired bacterial pneumonia, ventilator-associated bacterial pneumonia, and bacterial septicaemia.

Here's how you should administer Extacef Tazo 1125mg Injection 1:

The injection is to be given intravenously, preferably over one hour.
Make sure a trained healthcare professional administers the injection.
Before administering, ensure the solution is appropriately diluted with a compatible IV solution.
After reconstitution, the solution should be used within 24 hours if kept at room temperature or within 7 days if refrigerated.

Extacef Tazo 1125mg Injection 1 is administered intravenously.

Extacef Tazo 1125mg Injection 1 may cause common side effects such as nausea, diarrhea, headache, constipation, rash, fever, difficulty falling asleep, elevated liver enzymes (indicating liver function changes), and hypokalemia (low potassium levels).

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Extacef Tazo 1125mg Injection 1. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Extacef Tazo 1125mg Injection 1 consists of two active ingredients which work in tandem:

Ceftriaxone (1000 mg): The main function of this ingredient is to damage the wall of the bacteria's cell by binding to certain proteins (penicillin-binding proteins) on the cell's inner membrane. As a result, the peptidoglycan chainsformation is disrupted thus weakening the cell wall's strength and rigidity. This causes cell lysis.
Tazobactam (125 mg): It protects ceftriaxone from being broken down. Ceftriaxone can be broken down by enzymes (beta-lactamases) produced by resistant bacteria. By attaching itself to these enzymes and rendering them ineffective, tazobactam ensures that ceftriaxone can perform its antibacterial function even against resistant beta-lactamase-producing bacteria.

Pregnancy

Exercise caution when using Extacef Tazo 1125mg Injection 1 while pregnant. Inform your doctor if you are pregnant if this injection is prescribed to you.

Breastfeeding

Low levels of Extacef Tazo 1125mg Injection 1 are excreted in breast milk. Use this medicine with caution if you are breastfeeding, and monitor the infant for any adverse effects, such as diarrhoea or a rash. Follow your doctor's advice before taking this medication.

Alcohol

It is advised to avoid the consumption of alcohol if this injection is prescribed to you to avoid any adverse effects.

Liver

As an adult patient, if you have mild to moderate liver problems, exercise caution when using Extacef Tazo 1125mg Injection 1. Consult your doctor before starting this medicine, as it may affect liver function.

Kidney

If you have kidney health issues or impaired renal function, the dosage of Extacef Tazo 1125mg Injection 1 needs to be adjusted. It is advisable to consult your doctor before starting this medicine.

Use In Driving And Operating Machinery

Extacef Tazo 1125mg Injection 1 does not generally affect your ability to drive or operate machinery. It is advisable to monitor your body's response to this medication before performing such activities.

Allergy

If you have a history of allergies to antibiotics such as ceftriaxone or tazobactam, use Extacef Tazo 1125mg Injection 1 with caution. If a hypersensitivity reaction occurs, discontinue the medicine immediately.

Children

Extacef Tazo 1125mg Injection 1 should only be given to children under strict medical supervision.

Older Patients

Older patients should get Extacef Tazo 1125mg Injection 1 under medical supervision since they may be more susceptible to its side effects. Caution is advised if patients are over 65 years of age, as they might be on other medications.

Drug-Drug Interactions

Calcium-Containing Solutions (calcium gluconate and calcium chloride): The interaction of these with Extacef Tazo 1125mg Injection 1 can be fatal due to the risk of precipitation.
Aminoglycosides like gentamicin and amikacin may interact with Extacef Tazo 1125mg Injection 1, potentially increasing the risk of kidney damage.
Broad-spectrum antibiotics such as chloramphenicol when concomitantly used along with this medication, can reduce the effectiveness of Extacef Tazo 1125mg Injection 1.
Anticoagulants: If you're on blood thinners like warfarin or heparin, Extacef Tazo 1125mg Injection 1 could enhance their effects.
Uricosuric agents such as probenecid when taken alongside Extacef Tazo 1125mg Injection 1 can increase the levels of ceftriaxone in your body. Therefore, co-administration should be avoided.

Drug-Food Interactions

None

Drug-Disease Interactions

Liver disease: If you have a liver condition, caution is advised as this medication could exacerbate your condition.
Kidney disease: Renal function should be monitored in patients with kidney disease, as dose adjustments may be required.
Severe hypersensitivity: Patients who have severe allergies should exercise caution, as Extacef Tazo 1125mg Injection 1 could trigger an allergic reaction.

Daily Dose

Your doctor should prescribe the recommended dose of Extacef Tazo 1125mg Injection 1. The dosage may vary based on your condition and how you respond to the medicine. Always follow your doctor's prescribed dosage and never exceed it without consultation. For more details, refer to the package insert.

Over Dose

Overdose of this injection is unlikely as a healthcare professional will administer it. In the event of an overdose, you may experience symptoms such as nausea, vomiting, diarrhoea, and seizures. If these symptoms persist or worsen over time, inform your doctor immediately.

Missed Dose

Since this injection is administered by a healthcare professional, missing the dose is highly unlikely. However, if you miss it, inform the doctor immediately.

Store Extacef Tazo 1125mg Injection 1 in the refrigerator or at 2°C to 8°C.
Do not freeze this injection.
Keep the medicine away from direct light and moisture.
Always keep this medicine out of reach of children.

Drinking plenty of water can help flush bacteria out of your system.
Maintain a balanced diet with sufficient fibre to aid digestion and prevent constipation.

Fact Box

Dosage Forms Available	Injection
Habit Forming	No
Ailment	Intra-abdominal Infections, Urinary Tract Infections, and Bacterial pneumonia
Drug Category	Beta-Lactam Antibiotic
Therapeutic Category	Antibacterial

What is Extacef Tazo 1125mg Injection 1 used for?

It manages severe bacterial infections, including complex abdominal and urinary tract infections, hospital-acquired pneumonia, and bacterial septicaemia.

How does Extacef Tazo 1125mg Injection 1 work?

It combines ceftriaxone, which weakens bacterial cell walls, causing them to burst, with tazobactam, which blocks enzymes that resist antibiotics, enhancing the medicine's effectiveness.

Can I take this medicine if I am allergic to penicillin?

Caution is required as there can be cross-sensitivity between penicillins and cephalosporins like ceftriaxone. If an allergic reaction occurs, discontinue use and consult your doctor.

What are the side effects of Extacef Tazo 1125mg Injection 1?

Common side effects include nausea, diarrhoea, headaches, constipation, insomnia, fever, rash, and low potassium levels. Severe adverse reactions, such as anaphylactic reactions, may occur. If symptoms persist or worsen, seek medical attention immediately.

Can it be given to children or elderly patients?

The usage in neonates and the elderly should be done with caution. For neonates with hyperbilirubinaemia or receiving calcium-containing IV products, it's warned against use. Elderly patients should have their renal function monitored.

Can I use this medicine while breastfeeding?

Low levels of this medicine are excreted in breast milk. Use it with caution and monitor infants for symptoms such as diarrhoea, rash, and yeast infection.

What happens if I overdose on Extacef Tazo 1125mg Injection 1?

Overdose of this injection is unlikely as a healthcare professional administers it.

Last Updated On 05 Feb. 2026 | 11:29AM (IST)

Certified Content

Written by

Ashmita Borgohain

Medical Content Writer | 14 years

MSc (Applied Genetics)

Reviewed by

Dr. Saniya K Mulla

Medical Content Writer | 7 years

MBBS

Check out Editorial Policy

Manufacturer details

Peninsula Corporate Park, Peninsula Chambers, G.K Marg, Lower Parel West, Lower Parel, Mumbai, Maharashtra 400013

Country of origin: INDIA

Expiry on or after: February 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

U.S. Food and Drug Administration. (2004). Drug Approval Package: Rocephin (ceftriaxone sodium) NDA# 50-585/S-056 & 50-624/S-026. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2004/50585s056,50624s026lbl.pdf
U.S. Food and Drug Administration. (2014). Drug Approval Package: Avycaz (ceftazidime-avibactam) NDA# 206829. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/206829lbl.pdf
MedlinePlus. (n.d.). Ceftriaxone: MedlinePlus Drug Information. Retrieved from https://medlineplus.gov/druginfo/meds/a685032.html
MedlinePlus. (n.d.). Tazobactam: MedlinePlus Drug Information. Retrieved from https://medlineplus.gov/druginfo/meds/a615010.html
Tazobactam: Uses, Interactions, and Mechanisms of Action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01606
Puzniak, L., Dillon, R., Palmer, T., Collings, H., & Enstone, A. (2021). Real-world use of ceftolozane/tazobactam: a systematic literature review. Antimicrobial Resistance and Infection Control, 10(1). https://doi.org/10.1186/s13756-021-00933-8

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Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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