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Esomac HP Combo is used to treat peptic ulcers caused by H. pylori bacterial infection. This combination of antibiotics and a proton pump inhibitor works by killing the bacteria and reducing stomach acid to support ulcer healing. It also helps relieve symptoms such as stomach pain, nausea, bloating, heartburn, and loss of appetite. Consult with your doctor before taking this medicine.
Esomac HP Combo is used to treat peptic ulcer disease by healing sores in your stomach, upper small intestine, or esophagus. It also helps get rid of Helicobacter pylori bacteria, which often cause these ulcers. The tablet relieves common symptoms like stomach pain and acid reflux and manages conditions caused by too much stomach acid, helping you feel better and protect your digestive health.
Here's how you should take Esomac HP Combo:
Swallow the tablet whole with a glass of water.
Do not crush or chew the tablet; it needs to be swallowed whole.
It's best to take this medicine at least one hour before a meal.
Always follow the course as prescribed by your doctor, even if symptoms improve earlier.
If you're uncertain about any aspect of using this medicine, consult your doctor for advice.
Esomac HP Combo is taken orally.
Esomac HP Combo may cause side effects such as diarrhoea, nausea, abdominal pain, headache, vomiting, rash, indigestion, or flatulence. These effects are usually manageable, but consult a doctor if they become severe or persistent.
Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Esomac HP Combo. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.
Here are some general guidelines for managing common side effects:
Diarrhoea: Stay hydrated by drinking plenty of water.
Indigestion: Try taking Esomac HP Combo with food to lessen this effect.
Esomac HP Combo is composed of three active ingredients that work together to manage peptic ulcer disease:
Amoxicillin (750 mg): This antibiotic works by blocking the synthesis of bacterial cell walls. It prevents the cross-linkage of peptidoglycans which are critical components of the bacterial cell wall. This action eventually leads to cell lysis and death of the bacteria.
Clarithromycin (500 mg): This medication binds to a specific component of susceptible bacteria and suppresses protein synthesis. By inhibiting peptide translation, it stops bacterial growth and can be bactericidal at high concentrations or against highly susceptible organisms.
Esomeprazole (40 mg): This proton pump inhibitor suppresses gastric acid secretion. It irreversibly blocks an enzyme system in your stomach's parietal cells which inhibits the final step of acid production, leading to reduced gastric acidity.
Esomac HP Combo should only be taken during pregnancy if it is clearly needed. It's a good idea to discuss this with your doctor before starting the medicine.
Amoxicillin and clarithromycin, components of Esomac HP Combo, are found in human milk. If you are breastfeeding, caution is advised when taking this medicine. Consult your doctor to understand the potential risks and benefits.
There's no specific information on the interaction of alcohol with Esomac HP Combo. However, it's always wise to avoid alcohol while on medication.
If you have severe liver problems, you should exercise caution while taking Esomac HP Combo as its metabolism may be affected. Your doctor can provide further advice based on your health status.
Caution is advised while taking Esomac HP Combo if you have a history of any kidney problems. It is a good idea to consult your doctor before taking this medicine.
There's no information suggesting that Esomac HP Combo can affect your ability to drive or operate machinery. However, if you feel unwell or experience side effects like dizziness or visual disturbances, avoid these activities and consult your doctor.
If you're allergic to amoxicillin, clarithromycin, esomeprazole or any other ingredients in Esomac HP Combo, refrain from using this medicine.
Esomac HP Combo is not recommended for use in children as its safety and effectiveness have not been established for this age group.
Older patients should take Esomac HP Combo under medical supervision as they may be more susceptible to its side effects.
Esomac HP Combo interacts with the following medicines:
Antiretrovirals: Esomac HP Combo can interact with antiretroviral medications like ritonavir and saquinavir, potentially altering their effectiveness.
Antifungals such as ketoconazole or itraconazole may interact with Esomac HP Combo, possibly affecting their absorption in the body.
Calcium Channel Blockers like diltiazem, when taken with Esomac HP Combo, can have reduced effects.
Statins like simvastatin may interact with Esomac HP Combo, potentially leading to increased statin levels in the body.
Benzodiazepines: Esomac HP Combo can interact with medicines like diazepam, potentially altering their effects.
Warfarin: This medicine's blood-thinning effect can be affected when used alongside Esomac HP Combo.
Esomac HP Combo has known interactions with certain foods:
Grapefruit juice: This fruit juice can interfere with the body's absorption of clarithromycin, one of the components of Esomac HP Combo.
Esomac HP Combo can interact with the following diseases:
Liver disease: Individuals with liver disease might experience decreased metabolism of esomeprazole and clarithromycin, requiring potential dose adjustment.
Renal Impairment: In severe cases of renal dysfunction (GFR <30 mL/min), amoxicillin dosage adjustments may be necessary.
The daily dose of Esomac HP Combo should be taken as advised by your doctor. The dosage can vary based on factors like the severity of your condition and your body's response to the medicine. It's crucial to stick to the prescribed dosage and not to exceed it without consulting your doctor. For more details, read the package insert.
If you accidentally take more Esomac HP Combo than recommended, you might experience common side effects like confusion, drowsiness, blurred vision, and a rapid heartbeat. If these symptoms persist or worsen, inform your doctor.
If you forget to take a dose of Esomac HP Combo, take it as soon as you remember. But if it's almost time for your next dose, skip the missed one and continue with your regular schedule. Never increase your dosage without consulting your doctor.
Store Esomac HP Combo at temperatures below 25°C.
Keep it in a place that is dry and protected from light.
Make sure the medicine is out of reach of children.
Always check the expiry date on the packet before use.
As Esomac HP Combo is used to manage peptic ulcer disease caused by H. pylori infection, you should avoid food and drinks that cause stomach discomfort such as spicy foods, caffeine, and alcohol.
Engage in regular physical activity which can help reduce stress levels, as stress can worsen symptoms associated with peptic ulcers.
| Available Dosage Types | Kit |
| Habit Forming | No |
| Ailment | Peptic Ulcer Disease, H. pylori Infection |
| Drug Category | Penicillin-type Antibiotic, Macrolide Antibiotic, Proton Pump Inhibitor |
| Therapeutic Category | Antiulcerant |
Esomac HP Combo is used to manage peptic ulcer disease caused by a bacterial infection, Helicobacter pylori (H. pylori).
Esomac HP Combo contains two antibiotics that kill the H. pylori bacteria, and a proton pump inhibitor that reduces stomach acid, helping ulcers heal.
No, you should swallow Esomac HP Combo tablets whole, without chewing or crushing them.
Store Esomac HP Combo in a cool, dry place at temperatures below 25°C, protected from light and moisture, and out of children's reach.
If you're allergic to any components of Esomac HP Combo, don't take it. Also watch for severe skin reactions and hypersensitivity reactions that can occur.
Common side effects include diarrhoea, nausea, abdominal pain, headache, vomiting, flatulence, indigestion and rash. Seek immediate medical attention if these symptoms persist or worsen.
Some medicines can interact with Esomac HP Combo. Always consult your doctor before starting any new medication alongside it.
Check out Editorial Policy
Chen, L. W., et al. (2021). The Application of High-Dose Proton Pump Inhibitor Induction Treatment before Dual Therapy for Helicobacter pylori Eradication: An Open-Label Random Trial. Journal of clinical medicine, 10(19), 4352. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509452/
DailyMed (n.d.). Amoxicillin - amoxicillin capsule. Retrieved from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=40adc1d3-7ce7-4698-aa7f-b5dbaaecec00
ClinicalTrials.gov (2022). A study of amoxicillin and clarithromycin in healthy volunteers. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8509452/
Fock, K. M., Katelaris, P., Sugano, K., Ang, T. L., Hunt, R., Talley, N.J., ... Asia–Pacific Working Group. (2005). Second Asia–Pacific consensus guidelines for Helicobacter pylori infection. Journal of Gastroenterology and Hepatology, 20(5), 775-787. Retrieved from https://pubmed.ncbi.nlm.nih.gov/15691303/
U.S. Food and Drug Administration (2019). Pediatric Drug Development: Amoxicillin Clinical Review. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/pediatric/050813s000_Amoxicillin_Clinical_PREA.pdf
U.S. Food and Drug Administration (2019). Multi-Discipline Review: Application Number 213004Orig1s000. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/nda/2019/213004Orig1s000MultidisciplineR.pdf
U.S. Food and Drug Administration (2022). Drug Approval Package: NEXIUM I.V. (esomeprazole sodium) for Injection. Retrieved from https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/213593s000lbl.pdf
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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