Egolix 200 Tablet 10 is used for the management of moderate to severe pain associated with endometriosis in adult women. It belongs to the class of gonadotropin-releasing hormone (GnRH) receptor antagonists.
Endometriosis is a chronic gynaecological condition where tissue similar to the uterine lining grows outside the uterus, causing pelvic pain, painful menstruation, and discomfort during intercourse. This tablet does not cure endometriosis but helps reduce pain and improve daily functioning when taken as prescribed.
Before starting therapy with Egolix 200 Tablet 10, inform your doctor about the pregnancy. The treatment duration with this tablet should be limited because prolonged use may cause bone loss. The dose and duration are determined by your doctor based on symptom severity, liver function, and treatment response.
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Egolix 200 Tablet 10
Strip of 10 Units
MRP ₹900
₹720
₹90/Units
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CompositionAbout Egolix 200 Tablet 10
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Uses of Egolix 200 Tablet 10
Egolix 200 Tablet 10 is used for:
- Management of moderate to severe pain associated with endometriosis
- Reduction of pelvic pain and dysmenorrhea
Directions for Use of Egolix 200 Tablet 10
- Swallow the tablet whole with water.
- Take it approximately at the same time each day.
- It may be taken with or without food.
- Do not exceed the prescribed duration due to the risk of bone mineral density loss.
- Follow your doctor’s instructions regarding dose adjustments and monitoring.
Route of Administration
Egolix 200 Tablet 10 is meant for oral use.
Side Effects of Egolix 200 Tablet 10
Egolix 200 Tablet 10 may cause the following common side effects:
- Hot flushes and night sweats
- Headache
- Nausea
- Insomnia
- Mood changes or anxiety
- Amenorrhoea
- Joint pain
- Bone mineral density reduction
Managing the Side Effects:
Most side effects of Egolix 200 Tablet 10 are temporary and generally resolve after discontinuation of Egolix 200 Tablet 10. Seek medical advice if symptoms become severe or persistent.
- Nausea: Eat small frequent meals and avoid fatty foods.
- Insomnia: Maintain regular sleep routines and avoid caffeine before bedtime.
How Egolix 200 Tablet 10 Works?
Egolix 200 Tablet 10 contains the following active component:
- Elagolix (200 mg): Elagolix is a non-peptide GnRH receptor antagonist that competitively binds to GnRH receptors in the pituitary gland. It suppresses luteinizing hormone (LH) and follicle-stimulating hormone (FSH), thereby reducing estradiol and progesterone production and estrogen-dependent stimulation of endometriotic lesions and associated pain.
Safety Measures & Warnings
Pregnancy
Egolix 200 Tablet 10 is contraindicated during pregnancy because exposure may increase the risk of early pregnancy loss. Before starting therapy with Egolix 200 Tablet 10, inform your doctor if you are pregnant or think you may be pregnant. Pregnancy must be excluded before initiating therapy.
Breastfeeding
There is limited data regarding the safety of Egolix 200 Tablet 10 during breastfeeding. Use only if clearly recommended after medical evaluation.
Alcohol
Excessive alcohol intake may worsen liver stress and mood-related side effects. Limiting alcohol consumption is advisable.
Liver
Dose adjustment may be required in patients with moderate hepatic impairment. Egolix 200 Tablet 10 is contraindicated in severe hepatic impairment. Liver function tests may be recommended during treatment.
Kidney
No dosage adjustment is generally required in patients with renal impairment. Clinical monitoring remains necessary.
Using Machines & Driving
Egolix 200 Tablet 10 can cause headache, fatigue, or mood disturbances. Avoid operating machinery or driving if your concentration or alertness is affected.
Allergy
Patients with hypersensitivity to elagolix or formulation components should avoid using Egolix 200 Tablet 10. Severe allergic reactions require immediate medical attention.
Children
Egolix 200 Tablet 10 is not intended for children below 18 years of age.
Older Patients
Use of Egolix 200 Tablet 10 in post-menopausal women is generally not indicated. Risk–benefit assessment is necessary in older populations.
Interactions of Egolix 200 Tablet 10
Drug-Drug Interactions
Egolix 200 Tablet 10 interacts with the following medicines:
- Strong OATP1B1 inhibitors (e.g., cyclosporine, gemfibrozil): Contraindicated due to significantly increased elagolix exposure and adverse effects.
- Strong CYP3A inhibitors (e.g., ketoconazole, clarithromycin): May increase elagolix levels; duration limitation is required.
- CYP3A inducers (e.g., rifampicin, carbamazepine): May reduce elagolix effectiveness by lowering plasma concentrations.
- P-glycoprotein substrates (e.g., digoxin): Elagolix may increase plasma concentrations, requiring monitoring.
- Oestrogen-containing contraceptives: The concomitant use of Oestrogen-containing contraceptives and Egolix 200 Tablet 10 is not recommended, it may reduce the effectiveness of this tablet.
Drug-Disease Interactions
Egolix 200 Tablet 10 interacts with the following diseases/conditions:
- Osteoporosis: May worsen bone loss; contraindicated in patients with known osteoporosis.
- Mood changes: There is an increased risk of mood changes after taking this medication. Close monitoring is required.
Dosage of Egolix 200 Tablet 10
Daily Dose
The recommended dose of Egolix 200 Tablet 10 is decided by your doctor. This depends on individual factors, such as the severity of your condition and how you respond to the medicine. Always take the prescribed dosage and consult your doctor before making any changes.
Over Dose
Symptoms of overdosage may include exaggerated adverse effects such as nausea, headache, mood changes, or hormonal disturbances. Seek medical attention immediately if an overdose is suspected. Treatment is supportive and symptomatic.
Missed Dose
Take the missed dose of Egolix 200 Tablet 10 as soon as remembered, unless it is close to the next scheduled dose. Skip the missed dose if the next dose is due soon. Do not take a double dose.
Storage
- Store at room temperature in a dry place.
- Protect from moisture and direct sunlight.
- Keep out of reach and sight of children.
- Do not use after the expiry date printed on the packaging.
Diet & Lifestyle
- Ensure sufficient calcium and vitamin D intake.
- Weight-bearing activities help maintain bone density.
- Meditation or relaxation techniques may help manage mood changes.
- Include fruits, vegetables, lean protein, and whole grains.
- Use effective non-hormonal contraception during treatment and for at least one week after discontinuation.
Fact Box
| Available Dosage Types | Tablet |
| Habit Forming | No |
| Ailment | Endometriosis-associated pain |
| Drug Category | GnRH receptor antagonist |
| Therapeutic Category | Hormonal therapy |
Frequently Asked Questions (FAQs)
What is Egolix 200 Tablet 10 used for?
Can Egolix 200 Tablet 10 affect bone health?
Is contraception required during treatment?
Can Egolix 200 Tablet 10 cause mood changes?
Can adolescents use Egolix 200 Tablet 10?
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Manufacturer details
Country of origin: INDIA
References
- Incepta Pharmaceuticals Ltd. (n.d.). Elagolix Sodium INN - pharmacology, indications, dosage, side effects, precautions, contraindications, pregnancy & lactation, special populations, drug interactions, overdose, and storage conditions. https://www.inceptapharma.com/downloads/1679284705_pdoc_Origolix%20Leaflet.pdf
- Drugs.com. (2024). Elagolix: Uses, dosage, side effects, warnings. Retrieved from https://www.drugs.com/elagolix.html
- DrugBank Online. (2024). Elagolix: Drug information and pharmacology. Retrieved from https://go.drugbank.com/drugs/DB11979
Disclaimer
We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.
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