Cleft 20 Tablet 10

Sun Pharmaceutical Industries Ltd

Strip of 10 Units

Read Info

Old MRP ₹242.9

MRP ~~₹227.72~~

₹191.76

₹22.77/Units

15.79% off

*MRP inclusive of all taxes

100% genuine medicines

Safe & secure payments

15 days Easy returns

Prescription required for this medicine

Store Below 30^o C

Composition

Leflunomide (20 Mg)

Strength:

20 MG 10 MG

Cleft 20 Tablet 10 is used to manage rheumatoid arthritis and psoriatic arthritis in adults. As a DMARD, it works by suppressing the overactive immune response, helping to reduce joint stiffness, pain, and inflammation while preventing long-term joint damage.

This medicine suppresses the immune system. It targets the overactive immune cells involved in causing inflammation, pain, and joint damage, which are common features of rheumatoid and psoriatic arthritis.

Before beginning the treatment, it is essential to consult your doctor, who will determine the appropriate dosage and frequency based on your specific condition and health profile. Ensure that you inform your doctor about any pre-existing medical conditions, ongoing medications, or allergies to avoid potential complications. It is also crucial to report any side effects, such as gastrointestinal discomfort, skin reactions, or signs of infection, to your doctor promptly.

Customers also bought

Roseup Ultra Capsule 14

MRP~~₹915.28~~

₹732.22

20% OFF

Boneo Tablet 10

MRP~~₹259.88~~

₹207.9

20% OFF

Cipcal 500 Tablet 15

MRP~~₹98.11~~

₹48.96

50% OFF

Fol 5 Tablet 30

MRP~~₹47.56~~

₹38.05

20% OFF

Save 50.1% with Substitute

Ironergy Tablet 10

MRP~~₹213.56~~

₹192.2

10% OFF

Stiffgon Rs Capsule 14

MRP~~₹428.01~~

₹326.36

24% OFF

Cleft 20 Tablet 10 is used for the following:

Reduction of signs and symptoms in adults with active rheumatoid arthritis
Slowing down structural damage in adults with active rheumatoid arthritis
Improvement of physical function in adults with active rheumatoid arthritis
Management of symptoms in adults with active psoriatic arthritis

Follow these instructions while taking Cleft 20 Tablet 10:

Swallow the tablet whole with a glass of water.
Avoid crushing, breaking, or chewing the tablet.
Do not alter the dosage or stop taking the medicine without consulting your doctor first.

Cleft 20 Tablet 10 is taken orally.

Cleft 20 Tablet 10 may have the following common side effects:

Diarrhoea
Nausea
Abdominal pain
Oral ulcers
Hair loss
Rash
Headache
Dizziness

Managing the Side Effects:

Most side effects are temporary and generally harmless, which resolve on discontinuing the use of Cleft 20 Tablet 10. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some general guidelines for managing common side effects:

Diarrhoea: Try taking Cleft 20 Tablet 10 with food.
Nausea: Consider taking this medicine after meals to lessen this effect.

Cleft 20 Tablet 10 contains leflunomide (20 mg). The medicine acts on the body through the following mechanisms:

Inhibition of Pyrimidine Synthesis: Leflunomide blocks the production of pyrimidine, a crucial compound needed for the rapid multiplication of cells. This action targets overactive immune cells responsible for inflammation in arthritis.
Immune System Suppression: By inhibiting pyrimidine synthesis, leflunomide reduces immune system activity, thereby alleviating inflammation, pain, and joint damage while slowing the progression of rheumatoid and psoriatic arthritis.

Pregnancy

Cleft 20 Tablet 10 is strictly contraindicated during pregnancy as it can cause harm to the developing fetus. If you are pregnant or planning to conceive, discuss this with your doctor before starting the medication.

Breastfeeding

Breastfeeding is not recommended while taking Cleft 20 Tablet 10, as the medicine may pass into breast milk and harm the nursing infant. Consult your doctor to understand the risks and explore alternative treatment options.

Alcohol

Avoid consuming alcohol while on Cleft 20 Tablet 10 as it can increase the risk of liver damage. Discuss alcohol use with your doctor, especially if you have a history of liver problems.

Liver

Caution is advised when using Cleft 20 Tablet 10 in patients with mild to moderate liver impairment. It is contraindicated in cases of severe liver disease. This medicine may affect liver function, so routine liver function tests may be required. If you have any liver conditions, inform your doctor before starting treatment.

Kidney

Patients with a history of kidney problems should use Cleft 20 Tablet 10 cautiously. Kidney function should be monitored, and your doctor will decide whether this medication is suitable for you.

Using Machines & Driving

Cleft 20 Tablet 10 does not typically impair your ability to drive or operate machinery. However, if you experience side effects like dizziness, fatigue, or weakness, it is best to avoid such activities and consult your doctor.

Allergy

Do not take Cleft 20 Tablet 10 if you are allergic to leflunomide or any of its ingredients. Always check the composition of the medicine and consult your doctor if you have a history of allergies.

Children

Cleft 20 Tablet 10 is not recommended for children under 18 years of age. Always consult a pediatrician or healthcare provider before giving this medication to children.

Older Patients

Older patients (above 70 years) should take Cleft 20 Tablet 10 under strict medical supervision, as they may be more susceptible to side effects such as liver or kidney complications. Your doctor may adjust the dosage and closely monitor your health during treatment.

Drug-Drug Interactions

Cleft 20 Tablet 10 interacts with the following medicines:

Hepatotoxic medicines: Medicines like methotrexate can interact with Cleft 20 Tablet 10, potentially increasing the risk of serious liver injury.
Anticoagulants: Medicines like warfarin may interact with Cleft 20 Tablet 10, potentially increasing the anticoagulant effect.
Immunosuppressants: Combined use with other immune-suppressing medicines such as azathioprine or cyclosporine may increase the risk of infections.

Drug-Disease Interactions

Cleft 20 Tablet 10 interacts with the following diseases:

Severe Liver Disease: This medication is contraindicated in patients with severe liver impairment as it may worsen liver function.
Severe Infections: Patients with active severe infections should avoid starting Cleft 20 Tablet 10 until the infection is fully treated, as the medication suppresses the immune system.
Immune Deficiency: Due to its immunosuppressive effects, Cleft 20 Tablet 10 is not recommended for individuals with severe immune deficiencies.
Bone Marrow Disorders: This medicine can affect blood cell production, including white blood cells, red blood cells, and platelets, and is not suitable for patients with impaired bone marrow function.

Daily Dose

The daily dose of Cleft 20 Tablet 10 should be taken as directed by your doctor. The prescribed dosage may vary based on individual circumstances such as the severity of your condition and how you respond to the medicine. It's crucial to adhere to your doctor's instructions and not exceed the recommended dose without seeking medical advice.

Over Dose

If you accidentally take more than the recommended dose, you might experience side effects such as nausea, abdominal discomfort, or dizziness. Should these symptoms persist, inform your doctor. Always stick to the prescribed dosage to avoid such instances.

Missed Dose

If you forget to take your Cleft 20 Tablet 10, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and carry on with your normal schedule. Never double up your dosage without consulting your doctor.

Always keep Cleft 20 Tablet 10 in its original packaging.
Store it at room temperature, ideally below 25°C.
Keep it away from direct light and moisture to maintain its efficacy.
Make sure the medicine is kept out of the reach of children.
Remember to check the expiry date on the packet before using the medicine.

If you're taking Cleft 20 Tablet 10 for rheumatoid or psoriatic arthritis, aim to maintain a balanced diet rich in Omega-3 fatty acids (found in fish, walnuts, flaxseeds) which may help reduce inflammation.
Regular low-impact exercises like swimming or cycling can help keep your joints flexible and strong without causing pressure or pain. Always consult your doctor before starting any new exercise routine.

Fact Box

Available Dosage Types	Tablet
Habit Forming	No
Ailment	Rheumatoid Arthritis, Psoriatic Arthritis
Drug Category	Pyrimidine Synthesis Inhibitor
Therapeutic Category	DMARD (Disease-Modifying Antirheumatic Medicines)

What is Cleft 20 Tablet 10 used for?

Cleft 20 Tablet 10 is used to manage symptoms and slow down the progression of rheumatoid and psoriatic arthritis in adults.

How does Cleft 20 Tablet 10 work?

Cleft 20 Tablet 10 works by inhibiting the production of a substance needed for rapidly dividing cells, thus reducing inflammation and slowing arthritis progression.

Can Cleft 20 Tablet 10 be taken with food?

You must take the medicine as directed by your doctor.

What are the common side effects of Cleft 20 Tablet 10?

Side effects can include diarrhoea, nausea, abdominal pain, oral ulcers, hair loss, rash, headache, and dizziness. Consult your doctor if these persist or worsen.

Is Cleft 20 Tablet 10 safe during pregnancy?

No, Cleft 20 Tablet 10 may cause birth defects and should not be taken during pregnancy. Women must use reliable contraception during and after treatment.

What precautions should I take while using Cleft 20 Tablet 10?

Inform your doctor about all your health conditions especially liver disease, immunodeficiency, bone marrow problems, diabetes, and any active or chronic infections before starting this medication.

Can Cleft 20 Tablet 10 interact with other medicines?

Yes, it may interact with several medications such as hepatotoxic medicines and anticoagulants like warfarin. Always inform your doctor about all medicines you're currently taking.

Last Updated On 30 Oct. 2025 | 12:29PM (IST)

Certified Content

Written by

Dr. Divya Mandial

Medical Content Writer | 9 years

PhD in Chemistry

Reviewed by

Pragati Bhosale

Medical Content Reviewer | 4 years

M. Pharmacy

Check out Editorial Policy

Manufacturer details

SCO No. 14, Sector 5, Panchkula – 134114, Haryana

Country of origin: INDIA

Expiry on or after: April 2026

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

ARAVA. (n.d.). ARAVA Tablets (leflunomide) 10 mg, 20 mg, 100 mg. https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/020905s022lbl.pdf
Padda, I. S., & Goyal, A. (2023, June 3). Leflunomide. StatPearls - NCBI Bookshelf. https://www.ncbi.nlm.nih.gov/books/NBK557799/
Leflunomide: Uses, interactions, mechanism of action | DrugBank Online. (n.d.). DrugBank. https://go.drugbank.com/drugs/DB01097
Leflunomide: MedlinePlus drug information. (n.d.). https://medlineplus.gov/druginfo/meds/a600032.html

Was this product description useful?

39 people find this information helpful

Disclaimer

We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

Recommended Substitute

50.1% CHEAPER

Lefuheal 20 Tablet 10

Healing Pharma

Strip of 10 Units

₹113.63

₹11.36/Units

3862 users bought this instead

Quick links

Uses
Directions for Use
Route of Administration
Side Effects
Medicine Activity
Precautions & Warnings
Interactions
Dosage
Storage
Diet & Lifestyle
Fact Box
FAQs

More Products By Sun Pharmaceutical Industries Ltd

Istamet 50mg/500mg Tablet 15

MRP~~₹176.25~~

₹141

20% OFF

Save 50.1% with Substitute

Pantocid Dsr Capsule 15

MRP~~₹252.19~~

₹201.75

20% OFF

Save 50.1% with Substitute

Syndopa Plus Tablet 15

MRP~~₹41.18~~

₹32.94

20% OFF

Levipil 500 Tablet 15

MRP~~₹193.58~~

₹154.86

20% OFF

Save 50.1% with Substitute

Sompraz D 40 Capsule 15

MRP~~₹248.44~~

₹198.75

20% OFF

Save 50.1% with Substitute

Pantocid 40 Tablet 15

MRP~~₹183.69~~

₹146.95

20% OFF

Save 50.1% with Substitute

Oxra 10mg Tablet 14

MRP~~₹223.13~~

₹178.5

20% OFF

Save 50.1% with Substitute

Rosuvas 10 Tablet 15

MRP~~₹345.94~~

₹276.75

20% OFF

Save 50.1% with Substitute

Febutaz 40 Tablet 15

MRP~~₹230.62~~

₹184.5

20% OFF

Save 50.1% with Substitute

Gemer 2 Tablet 15

MRP~~₹237.18~~

₹189.74

20% OFF

Save 50.1% with Substitute

Gemer 1 Tablet 15

MRP~~₹157.32~~

₹125.86

20% OFF

Save 50.1% with Substitute

Famocid 40 Tablet 14

MRP~~₹10.78~~

₹8.62

20% OFF

Save 32.78% with Substitute

Sompraz 40 Tablet 15

MRP~~₹158.2~~

₹126.56

20% OFF

Save 50.1% with Substitute

Istamet 50mg/1000mg Tablet 15

MRP~~₹178.13~~

₹142.5

20% OFF

Save 50.1% with Substitute

Prolomet Xl 25 Tablet 15

MRP~~₹63.78~~

₹51.02

20% OFF

Save 50.1% with Substitute

Mesacol Od Tablet 15

MRP~~₹541.88~~

₹433.5

20% OFF

Save 50.1% with Substitute

Prazopress Xl 5 Tablet 30

MRP~~₹524.06~~

₹419.25

20% OFF

Save 50.1% with Substitute

Axcer 90mg Tablet 14

MRP~~₹491.25~~

₹393

20% OFF

Save 50.1% with Substitute

Aztor 10 Tablet 15

MRP~~₹79.63~~

₹63.7

20% OFF

Save 50.1% with Substitute

Prolomet Xl 50 Tablet 15

MRP~~₹93.55~~

₹74.84

20% OFF

Save 50.1% with Substitute

Top-Selling Health Essentials

Calcigen 500 Tablet 15

MRP~~₹85.55~~

₹42.69

50% OFF

Tendocare Forte Tablet 15

MRP~~₹622.88~~

₹498.3

20% OFF

Save 50.1% with Substitute

Bio D3 Strong Capsule 10

MRP~~₹263.18~~

₹210.54

20% OFF

Save 50.1% with Substitute

Centrum Ostocalcium Total Mixed Fruit Flavour Chewable Tablet 30

MRP~~₹231~~

₹196.35

15% OFF

Cartigen Pro Tablet 10

MRP~~₹729.66~~

₹583.73

20% OFF

Save 50.1% with Substitute

Gemcal Plus Capsule 15

MRP~~₹445.31~~

₹356.25

20% OFF

Save 50.1% with Substitute

Tendocare Tablet 15

MRP~~₹444.92~~

₹355.94

20% OFF

Save 50.1% with Substitute

Lupical 500 Tablet 15

MRP~~₹84.47~~

₹50.68

40% OFF

Jointace C2 Tablet 10

MRP~~₹320.34~~

₹223.31

30% OFF

Roseup Hd Capsule 14

MRP~~₹826.65~~

₹661.32

20% OFF

Calcimax + Suspension 200ml

MRP~~₹160~~

₹128

20% OFF

Save 50.1% with Substitute

Cal 123 Total Tablet 15

MRP~~₹346.88~~

₹277.5

20% OFF

Gerijoint Capsule 10

MRP~~₹533~~

₹426.4

20% OFF

T Heal Capsule 15

MRP~~₹436.91~~

₹339.7

22% OFF

Calciquick Ct Tablet 15

MRP~~₹275~~

₹137.22

50% OFF

Calcimax P Tablet 15

MRP~~₹200.21~~

₹154.16

23% OFF

Calcigiant Ccm Tablet 40

MRP~~₹326.5~~

₹208.96

36% OFF

Jointace Trio Capsule 10

MRP~~₹840.89~~

₹630.67

25% OFF

Rosiflex C Capsule 20

MRP~~₹416.95~~

₹333.56

20% OFF

Dical D Tablet 10

MRP~~₹130.36~~

₹104.29

20% OFF

Health Articles

View All

Pregnancy & Reproduction

What AMH Level is Needed to Get Pregnant? A Fertility Guide

Diet

The Monsoon Diet: Enhancing Immunity and Digestive Health

Fitness

How to Reduce Stubborn Waist Fat: Effective Tips and Exercise

Exercise

10 Indoor Workouts to Boost Your Health During Winter

Diet

Best Fruits to Eat During Pregnancy for a Healthy Baby

Pregnancy & Reproduction

Best Sleeping Positions During Pregnancy for Comfort and Health

Weight management

High-Calorie Foods: 21 Best Choices for Healthy Weight Gain

Immunity & Hormones

10 Ways to Support and Strengthen Immunity Power

Diet

Why Protein is So Important in Your Diet?

Oral Care

8 Homemade Mouthwash Recipes to Improve Oral and Dental Health

ENT

5 Routine Eye Care Tips

Health Benefits

7 Benefits of Vitamin C for Your Skin

Top-Searched Medicines

Related Products

Company

About Us Health Article Health Stories Health Library Diseases & Health Conditions Ayurveda All Medicines All Brands Need Help FAQ Security

Social

Legal

Terms & Conditions Privacy Policy Editorial Policy Returns & Cancellations

Claim your complimentary health and fitness tips subscription and stay updated on our newest promotions.

Registered Office Address

Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

Grievance Officer

Name: Chandrasekhar Swaminathan

Email: grievance-officer@truemeds.in

Download Truemeds

Manage your health with ease Download Truemeds today!Get easy access to medicine refills, health information, and more. With our app, you'll never have to wait in line again. Download now and start taking control of your health.