Zoryl M 4 Forte Tablet 15

Intas Pharmaceuticals Ltd

Strip of 15 Units

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MRP ~~₹305.5~~

₹244.4

₹20.37/Units

20% off

*MRP inclusive of all taxes

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15 days Easy returns

Prescription required for this medicine

Store Below 30° C

Composition

Glimepiride (4 Mg) + Metformin (1000 Mg)

Zoryl M 4 Forte Tablet 15 is used to help control blood sugar levels. It is a combination antidiabetic medicine containing glimepiride and metformin.
This medicine helps manage blood glucose levels in type 2 diabetes. It also supports ongoing diabetes control alongside diet and exercise.
Regular meals, a balanced diet and physical activity can support blood sugar control alongside this medicine.
Before starting, tell your doctor about your medical conditions and allergies. Tell the doctor about all other medicines, supplements or herbal products you take. Tell your doctor if you are pregnant, planning a pregnancy or breastfeeding. Attend any monitoring appointments advised by your doctor. Report persistent or serious side effects to your doctor. Do not stop taking or using the medicine unless your doctor advises you to do so.

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Zoryl M 4 Forte Tablet 15 is used to help control blood sugar levels.

Uses of Zoryl M 4 Forte Tablet 15 are:

Blood Sugar Control: Helps manage blood glucose levels in type 2 diabetes.
Insulin Sensitivity: Improves the body's response to insulin.
Long-term Management: Supports ongoing diabetes control alongside diet and exercise.

Always consume the tablet with a meal.
Swallow the tablet whole; do not chew or crush it.
Always follow your doctor's advice on the frequency of usage.
If you're unsure about anything, don't hesitate to consult your doctor.

Zoryl M 4 Forte Tablet 15 is taken orally.

Zoryl M 4 Forte Tablet 15 may cause some side effects that are usually mild and go away as your body adjusts to the medicine.

A few common side effects of Zoryl M 4 Forte Tablet 15:

Low blood sugar: hypoglycaemia (low blood sugar), which may cause sweating, shakiness or hunger.
Digestive: loose motions (diarrhoea), feeling sick (nausea), vomiting and stomach pain.
Metabolic: vitamin B12 deficiency with prolonged use, which may cause tiredness or numbness.

If any side effect does not improve or becomes serious, speak to your doctor. Do not stop taking the medicine unless your doctor advises you to do so.

Management Of Side Effects:

Most side effects are temporary and generally harmless, which resolve upon discontinuing the use of Zoryl M 4 Forte Tablet 15. However, if you experience any serious side effects or worsening of any of the symptoms, please consult your doctor.

Here are some suggestions for managing common side effects:

Hypoglycaemia: If you experience low blood sugar symptoms like dizziness or confusion after taking Zoryl M 4 Forte Tablet 15, try having a small snack or meal that includes carbohydrates.
Gastrointestinal symptoms: If you have symptoms like nausea or diarrhoea after taking this medicine, take it with your main meals to lessen these effects.

Zoryl M 4 Forte Tablet 15 contains two active ingredients that work together to manage blood sugar levels:

Glimepiride (4 mg): This is a sulfonylurea class of medication that stimulates the pancreas to produce more insulin. It does this by binding to receptors on pancreatic beta cells, leading to increased secretion of insulin, which helps lower blood glucose levels.
Metformin (1000 mg): This ingredient works by reducing glucose production in the liver, decreasing glucose absorption from the intestines, and improving insulin sensitivity. This means it helps your body respond better to insulin and utilise glucose more effectively, thereby lowering overall blood sugar levels.

Pregnancy

Zoryl M 4 Forte Tablet 15 is not recommended for use during pregnancy. If you are pregnant or planning to conceive, it's important to discuss this with your doctor before starting this medicine.

Breastfeeding

Zoryl M 4 Forte Tablet 15 is not recommended if you are breastfeeding. Make sure to consult your doctor to understand potential risks and benefits.

Alcohol

Excessive alcohol intake should be avoided while taking Zoryl M 4 Forte Tablet 15, as it may affect the medicine's ability to manage your blood sugar levels and increase the risk of lactic acidosis.

Liver

Caution is advised while taking Zoryl M 4 Forte Tablet 15 if you have liver problems. This medicine may affect liver function, so discuss your condition with your doctor before starting this medication.

Kidney

Zoryl M 4 Forte Tablet 15 should not be taken if you have kidney problems. It's best to consult your doctor about any kidney-related concerns before starting this medication.

Use In Driving And Operating Machinery

Zoryl M 4 Forte Tablet 15 can cause hypoglycaemia, which can lead to dizziness or confusion. Caution is advised when driving or operating heavy machinery until you know how this medicine affects you.

Allergy

If you have a history of allergic reactions to glimepiride or metformin, or other sulfonylureas or biguanides, consult your doctor before taking Zoryl M 4 Forte Tablet 15.

Children

Zoryl M 4 Forte Tablet 15 is not recommended for use in children under 18 years of age. If needed for a child, always consult a doctor first.

Older Patients

Older patients should take Zoryl M 4 Forte Tablet 15 under medical supervision as they may be more susceptible to its side effects. Caution is advised if patients are above 70 years of age. Your doctor will guide you based on your health status.

Drug-Drug Interactions

Zoryl M 4 Forte Tablet 15 interacts with the following medicines:

Antidiabetic medications: Medicines like insulin or sulfonylureas may interact with Zoryl M 4 Forte Tablet 15, potentially leading to lower blood sugar levels than expected.
Diuretics: Medicines like furosemide and thiazides can affect blood glucose control when taken with Zoryl M 4 Forte Tablet 15.
Corticosteroids: Medication such as prednisone may increase blood glucose levels, reducing the effectiveness of Zoryl M 4 Forte Tablet 15.
Thyroid medicines: Medicines like levothyroxine can alter blood glucose levels, affecting the action of Zoryl M 4 Forte Tablet 15.
Oral contraceptives: Medications like combination pills (oestrogen and progesterone) and progesterone-only pills, may increase blood glucose levels, making it necessary to adjust the dosage of Zoryl M 4 Forte Tablet 15.
ACE inhibitors: Medications like enalapril may enhance the blood sugar-lowering effect of Zoryl M 4 Forte Tablet 15.

Drug-Food Interactions

Certain foods may interact with Zoryl M 4 Forte Tablet 15, altering its effect. Ideally:

High-fat meals: These should be avoided as they could delay absorption of metformin in the body.

Drug-Disease Interactions

Zoryl M 4 Forte Tablet 15 interacts with the following diseases:

Liver disease: Patients with liver disease should use this medicine cautiously as it could exacerbate their condition.
Kidney disease: In patients with kidney disease, this medicine may accumulate in the body and lead to lactic acidosis.

Daily Dose

The daily dose of Zoryl M 4 Forte Tablet 15 should be taken as advised by your doctor. This may vary based on individual factors like the seriousness of your condition and how you respond to the medicine. It's crucial to stick to the prescribed dosage and not exceed it without consulting your doctor.

Over Dose

If you accidentally take more than the prescribed dose of Zoryl M 4 Forte Tablet 15, you might experience symptoms such as nausea, vomiting or diarrhoea. If these symptoms persist or worsen, inform your doctor right away.

Missed Dose

If you forget to take a dose of Zoryl M 4 Forte Tablet 15, take it as soon as you remember. However, if it's nearly time for your next dose, skip the missed one and continue with your regular schedule. Do not increase your dosage without consulting your doctor.

Keep Zoryl M 4 Forte Tablet 15 stored in a cool, dry and dark place, ideally between 15°C to 30°C.
Shield the medicine from direct light and moisture to maintain its effectiveness.
Always remember to keep this medicine out of reach of children.
Pay attention to the expiry date stated on the label, use the product before it expires.

Follow a balanced diet low in refined sugars. Opt for whole grains, lean proteins, fruits and vegetables instead.
Regular physical activity is also crucial. Try adding at least 30 minutes of moderate-intensity exercise, such as brisk walking or cycling, to your daily routine.

Fact Box

Dosage Forms Available	Tablet
Habit Forming	No
Ailment	Type 2 diabetes
Drug Category	Sulfonylurea, Biguanide
Therapeutic Category	Antidiabetic

What should I do if I miss a dose of Zoryl M 4 Forte Tablet 15?

Take the missed dose as soon as you remember, alongside food. If it's nearly time for your next dose, skip the missed one. Continue with your regular schedule.

Can Zoryl M 4 Forte Tablet 15 be taken on an empty stomach?

No, always take this medicine with meals to lessen the chances of an upset stomach. Consult your doctor for more guidance.

How long does it take for Zoryl M 4 Forte Tablet 15 to work?

The medicine may take several days to weeks to fully work. Remember to take it consistently as prescribed by your doctor.

What should I avoid while taking Zoryl M 4 Forte Tablet 15?

Avoid alcohol as it raises the risk of lactic acidosis. Also, avoid dehydration and excessive exertion, especially in hot weather.

Is Zoryl M 4 Forte Tablet 15 safe during pregnancy?

This medicine is not recommended for use in pregnancy. Consult your doctor if you conceive or plan to conceive while on this medication.

Will Zoryl M 4 Forte Tablet 15 cause low blood sugar?

Yes, this medicine can cause low blood sugar, especially if you miss meals, exercise more than usual or drink alcohol.

Can I crush or chew Zoryl M 4 Forte Tablet 15?

No, swallow the tablet whole without crushing or chewing it to maintain its extended-release properties.

Last Updated On 18 Sep. 2026 | 7:24PM (IST)

Certified Content

Written by

Dr. Michelle Frank

Medical Content Writer | 10 years

Doctor of Medicine

Reviewed by

Dr. Divya Chauhan

Medical Content Writer & Reviewer | 8 years

BAMS, APG, PG

Check out Editorial Policy

Manufacturer details

Corporate House, Near Sola Bridge, S. G. Highway, Thaltej, Ahmedabad 380054, Gujarat, India

Country of origin: INDIA

Expiry on or after: February 2027

In case of any issues, contact us:

support@truemeds.in|09240250346

Address: 6th floor, Urmi Corporate Park Solaris, Saki Vihar Road, Andheri East, Mumbai 400071

References

DailyMed—METFORMIN HYDROCHLORIDE tablet, extended-release. (n.d.). Retrieved 29 August 2024, from https://dailymed.nlm.nih.gov/dailymed/lookup.cfm?setid=1200ea71-8a9e-4e49-bb77-7d9fe0d84ae7
NHS. (2021). Glimepiride: how and when to take it. Retrieved April 1, 2024, from https://www.nhs.uk/medicines/glimepiride/how-and-when-to-take-glimepiride/
U.S. Food and Drug Administration. (2006). Highlights of prescribing information. Retrieved April 1, 2024, from https://www.accessdata.fda.gov/drugsatfda_docs/label/2006/021748s002lbl.pdf
Glimepiride. (n.d.). Retrieved 18 June 2024, from https://go.drugbank.com/drugs/DB00222
Glimepiride: medlineplus drug information. (n.d.). Retrieved 10 August 2024, from https://medlineplus.gov/druginfo/meds/a696016.html
Sharma, S., Tandon, V. R., Roshi, null, & Mahajan, A. (2016). Prescribing pattern of oral antihyperglycaemic drugs, rationality and adherence to American diabetes association (Ada) treatment guidelines among type 2 diabetes mellitus (T2dm) postmenopausal women. Journal of Clinical and Diagnostic Research: JCDR, 10(1), OC11-15. https://doi.org/10.7860/JCDR/2016/16044.7063

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We, at Truemeds make a diligent attempt to deliver accurate, expert- drafted and thoroughly reviewed medicine related information to our consumers. However, it should, by no means, be considered a substitute for prescription from a certified doctor or a trustworthy doctor-patient relationship. In fact we detest any form of self medication without expert advice. The sole purpose of the information on our portal is to educate our consumers, which helps improve the communication between a doctor and a patient. The information by no means is complete in its entirety and should not be used to diagnose or treat any medical condition. No amount of information can replace the experience and expertise of a doctor, therefore his/her advice always holds priority and should be followed appropriately.

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Intellihealth Solutions Private Limited

Unit-301 & 304, Lightbridge Tunga Village, Saki Vihar Rd, Chandivali, Powai, Mumbai, Maharashtra, India, 400072.

CIN: U62099MH2019PTC320566

Telephone:09240250346

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Name: Kishor Kumar

Email: grievance-officer@truemeds.in

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